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This study uses advanced 7Li MRI to reveal how brain lithium kinetics closely track serum levels in bipolar disorder patients under once- versus twice-daily lithium dosing, highlighting implications for dosing schedules and therapeutic moni
The phase 2 NOVA1 trial demonstrates that LB-102 significantly improves acute schizophrenia symptoms with a favorable safety profile, supporting its potential as a novel treatment option.
A retrospective cohort study of ACCESS Open Minds in Canada demonstrates significant cost savings and improved service utilization in youth mental health care through enhanced, community-based services.
The BOOTS multicenter RCT found no significant difference in long-term effectiveness between dialectical behavior therapy (DBT) and schema therapy (ST) for borderline personality disorder (BPD), with both treatments yielding substantial cli
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within o
STAR 试验证实，以创伤为焦点的 CBTp 对合并 PTSD 和精神病的成人而言是一种安全、有效的干预，可改善 PTSD 与精神病症状，且可接受性高、不良事件少。
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A novel Psychiatric Model of Care integrating specialized nurse practitioners in the ED significantly reduced length of stay for psychiatric emergency patients, particularly those on involuntary holds, enhancing efficiency and patient flow.
A statewide Australian cohort study reveals lithium exposure during pregnancy doubles risk of spontaneous preterm birth and raises risks of cardiac malformations and large-for-gestational-age infants, informing clinical decision-making.
This review synthesizes randomized trial evidence demonstrating that intermittent theta burst stimulation (iTBS) targeting the dorsomedial PFC modulates default mode network activity, enhancing expectancy-driven placebo mood responses in de
This randomized clinical trial evaluated mirtazapine’s safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine
A qualitative study across 12 Colorado hospitals found that an EHR-embedded OUD intervention improved awareness but still faced stigma, inconsistent messaging, limited addiction expertise, and workflow barriers to MOUD initiation.
A randomized trial found that an 8-week digital mindfulness app improved anxiety, depression, and stress in adults with non-infectious uveitis, but did not significantly change vision-related quality of life.
In treated Cushing syndrome, normal late-night salivary cortisol was linked to better mood, quality of life, and metabolic outcomes, suggesting circadian cortisol restoration may be a meaningful recovery target.
In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr
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