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This study investigates the genetic risk structure of 18 psychiatric and substance use disorders using high-quality Swedish registries, identifying six distinct genetic factors and highlighting shared and unique genetic influences among dis
Nearly half of psychoactive medications newly prescribed after ICU stays in American adults lack documented diagnostic justification, persisting for up to two years post-hospitalization.
An international study reveals that childhood trauma’s association with bipolar disorder is partially mediated by brain morphology changes, particularly in hippocampal volume and frontal cortical thickness.
A large-scale study identifies key active components of psychosocial interventions delivered by non-specialists, revealing social support, behavioral activation, and problem management as most effective for treating common mental disorders,
This article critically examines the FDA’s approval of gepirone ER for major depressive disorder despite multiple negative trials, highlighting regulatory flexibility, statistical and clinical considerations, and implications for tran
This Swedish register-based study reveals that GLP-1 receptor agonists are associated with significantly reduced hospitalisations for alcohol and substance use disorders during treatment, with some lasting benefits after discontinuation of
This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.
In Eileen Chang's classic novel Red Rose, White Rose , she mocked men who are fickle in love: "Maybe every man has had two such women—at least two. Ma
A reader, Mark, asked: "Hey Nineteen, my wife and I have been married for two years. We have a great relationship, but we keep running into one issue:
This review synthesizes evidence on individual and institutional factors linked to suspected suicide among higher-education students in England, highlighting risk profiles, service contact patterns, and shortcomings in investigation practic
This analysis of six antipsychotic trials reveals distinct temporal patterns in the improvement of schizophrenia symptom domains, with hostility and excitement responding fastest and negative and cognitive symptoms improving more slowly, gu
This article examines the current gaps and strengths in mental health services for trauma surgery patients at risk of PTSD, highlighting underutilization of guidelines, barriers to care, and opportunities for improving psychosocial support.
Continuing antidepressants in pregnancy lowers postpartum depression risk irrespective of race or ethnicity; prenatal depressive symptoms severity is critical for personalized treatment.
Preoperative use of serotonergic antidepressants is linked to increased short-term postoperative complications after rhinoplasty, including higher rates of bleeding, readmission, and opioid use, without affecting long-term revision rates.
Peer networks in adolescence, especially in upper secondary school, significantly influence the risk trajectory for mental disorders through peers’ diagnosed conditions and genetic predispositions, with subtype-specific and cross-diso
A study of over 94,000 ED visits found that intramuscular chemical sedation during mental health consultations was more common among Black patients, those arriving with EMS or law enforcement, and those on involuntary holds.
A Danish cohort study of 67,390 women found no lasting increase in psychotropic medication use after medication or procedural abortion. Small first-year increases were not significant after correction for multiple testing, while long-term use was lower.
A new narrative review synthesizing evidence from 1980 to 2025 argues that schizophrenia spectrum disorders cannot be explained solely by dopaminergic dysfunction. The authors propose a pluralistic model involving multiple neurochemical and cellular processes, with implications for treatment development and biomarker-based stratification.
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
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