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Peer networks in adolescence, especially in upper secondary school, significantly influence the risk trajectory for mental disorders through peers’ diagnosed conditions and genetic predispositions, with subtype-specific and cross-diso
A study of over 94,000 ED visits found that intramuscular chemical sedation during mental health consultations was more common among Black patients, those arriving with EMS or law enforcement, and those on involuntary holds.
A Danish cohort study of 67,390 women found no lasting increase in psychotropic medication use after medication or procedural abortion. Small first-year increases were not significant after correction for multiple testing, while long-term use was lower.
A new narrative review synthesizing evidence from 1980 to 2025 argues that schizophrenia spectrum disorders cannot be explained solely by dopaminergic dysfunction. The authors propose a pluralistic model involving multiple neurochemical and cellular processes, with implications for treatment development and biomarker-based stratification.
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
This study uses advanced 7Li MRI to reveal how brain lithium kinetics closely track serum levels in bipolar disorder patients under once- versus twice-daily lithium dosing, highlighting implications for dosing schedules and therapeutic moni
The phase 2 NOVA1 trial demonstrates that LB-102 significantly improves acute schizophrenia symptoms with a favorable safety profile, supporting its potential as a novel treatment option.
A retrospective cohort study of ACCESS Open Minds in Canada demonstrates significant cost savings and improved service utilization in youth mental health care through enhanced, community-based services.
The BOOTS multicenter RCT found no significant difference in long-term effectiveness between dialectical behavior therapy (DBT) and schema therapy (ST) for borderline personality disorder (BPD), with both treatments yielding substantial cli
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within o
STAR 试验证实，以创伤为焦点的 CBTp 对合并 PTSD 和精神病的成人而言是一种安全、有效的干预，可改善 PTSD 与精神病症状，且可接受性高、不良事件少。
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A novel Psychiatric Model of Care integrating specialized nurse practitioners in the ED significantly reduced length of stay for psychiatric emergency patients, particularly those on involuntary holds, enhancing efficiency and patient flow.
A statewide Australian cohort study reveals lithium exposure during pregnancy doubles risk of spontaneous preterm birth and raises risks of cardiac malformations and large-for-gestational-age infants, informing clinical decision-making.
This review synthesizes randomized trial evidence demonstrating that intermittent theta burst stimulation (iTBS) targeting the dorsomedial PFC modulates default mode network activity, enhancing expectancy-driven placebo mood responses in de
This randomized clinical trial evaluated mirtazapine’s safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine
