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A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
VHA study reveals only 30% of veterans hospitalized for AUD receive evidence-based medications during or shortly after hospitalization, with significant variation across hospitals and demographic factors influencing prescription rates.
In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.
This review synthesizes evidence on the high prevalence and severity of intimate partner violence (IPV) among veterans with substance use disorders, highlighting gender-specific lethality risks and the critical need for integrated screening
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
The Systems Analysis and Improvement Approach for Mental Health (SAIA-MH) significantly improved functional outcomes, medication adherence, and appointment attendance in Mozambican outpatient clinics, offering a scalable model for low-resou
A proactive digital mental health platform improved mental health outcomes for health care workers, with notable benefits for Black and female participants in work productivity and sustained depression reduction.
A landmark Swedish cohort study of 95,490 patients reveals that semaglutide is associated with a 42% lower risk of worsening mental illness in people with depression and anxiety, while other GLP-1 receptor agonists show varied effects. The
Secondary analysis of the MYRIAD trial reveals that while machine learning models can identify adolescents who may benefit from school-based mindfulness training, the clinical relevance of such predictions remains minimal. Both causal fores
This study analyzes emergency department visit patterns among suicide decedents, identifying frequent users and a critical 30-day window for intervention after discharge.
A large multicenter study finds that while maternal depression does not affect inpatient opioid use after cesarean delivery, untreated depression significantly increases outpatient opioid consumption and perceived pain interference during t
A comprehensive study of 569 cystic fibrosis professionals identifies physicians as the group most vulnerable to burnout, emotional exhaustion, and depersonalization. The research highlights administrative burden as a primary driver and cal
A large-scale Korean cohort study reveals thyroid cancer survivors face a significantly higher risk of depression in the first five years post-diagnosis, independent of treatment modality or hormone dosage.
This study examines the timing and frequency of emergency department visits among individuals who died by suicide. Research identifies frequent ED use as a high-risk indicator and suggests that the 30-day window following an emergency visit
A prospective cohort study demonstrates that antipsychotic use in critically ill patients is significantly associated with fewer catatonia-free days, suggesting that dopamine blockade may be a primary driver of catatonic syndromes in intens
A study of 3,910 former college athletes found that a history of multiple concussions is significantly linked to worse mental health and sleep quality within five years of retirement, though most remain within normal clinical ranges.
This translational study demonstrates that the FKBP5 protein, a regulator of the stress response, significantly influences stroke outcomes. Lower FKBP5 levels correlate with smaller brain lesions in mice, while high-expression genetic varia
This study highlights how comorbid Alzheimer’s and FTLD neuropathologies manifest through unique neuropsychiatric profiles, such as increased anxiety and personality changes, providing clinicians with vital clues for identifying mixed
A large-scale retrospective study reveals that anxiety and depression following the diagnosis of unruptured intracranial aneurysms significantly increase the risk of rupture and all-cause mortality, suggesting that integrated psychiatric as
This landmark network meta-analysis of 438 RCTs evaluates 24 antipsychotics, revealing clozapine as the most effective while highlighting the novel muscarinic agonist xanomeline-trospium. The study emphasizes clinically relevant efficacy di
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