Section
The FELICIA phase IIb trial found that adding metformin to progestin therapy for fertility-sparing treatment in endometrial neoplasia did not improve 3-year recurrence-free survival or remission rates, though some reproductive outcomes favo
This review synthesizes phase 2 trial data supporting neoadjuvant stereotactic ablative radiotherapy for RCC with IVC tumor thrombus, highlighting improved recurrence-free survival, acceptable safety, and biomarker insights that underscore
Lichen planus is linked to increased risks of oral and genital cancers, with risks correlating to lesion sites. Despite low absolute risks, vigilant cancer surveillance in LP patients is warranted.
This review synthesizes evidence from large cohort studies and meta-analyses highlighting bariatric surgery’s association with reduced risks of many obesity-related cancers, consistent across age and sex. Mechanistic insights and impl
This study compares surgical outcomes in prepectoral tissue expander breast reconstruction following mastectomy, revealing that adjuvant chemotherapy increases major complication risks, while neoadjuvant chemotherapy and perioperative leuko
This study reports durable tumor control and meaningful visual preservation up to 20 years after 103Pd plaque brachytherapy for choroidal melanoma, providing valuable long-term data for clinical decision-making.
This study identifies a link between exposure to wildfire-specific PM2.5 air pollution and increased risks of head and neck cancers over a 10-year period, with notable effects on oral cavity, oropharyngeal, and laryngeal cancers.
This review synthesizes evidence comparing laparoscopic radiofrequency ablation and myomectomy for uterine leiomyomata, highlighting higher treatment failure rates with RFA and identifying predictive factors influencing outcomes.
The PERSONA-Ovary trial demonstrates the feasibility and clinical value of unselected germline multigene panel testing alongside somatic BRCA analysis in ovarian carcinoma, revealing a 29.7% pathogenic variant prevalence and optimal testing
The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and m
This study shows that prior implant-based reconstruction combined with radiotherapy increases perioperative microvascular complications but not flap necrosis in delayed DIEP flap breast reconstruction, highlighting increased surgical comple
Omission of sentinel lymph node biopsy (SLNB) in select postmenopausal patients with early HR+/HER2- breast cancer and negative axillary ultrasound is feasible and safe, reducing surgical morbidity without compromising short-term outcomes.
An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combin
This study reveals that ameloblastomas uniquely maintain primary cilia and exhibit CEP164 overexpression, highlighting a distinct molecular signature that may influence tumor behavior and offer new diagnostic and therapeutic avenues.
The ROAM/EORTC-1308 trial demonstrates that adjuvant radiotherapy after complete surgical resection of atypical meningioma significantly improves 5-year disease-free survival, reducing recurrence risk with manageable adverse effects.
This study provides a comprehensive single-cell immune atlas of multiple myeloma, revealing dynamic tumor microenvironment ecotypes linked to disease progression, immune dysfunction, and treatment response, offering new avenues for precisio
A large single-center cohort study found no increased incidence of malignancy in patients with IgG4-related disease (IgG4-RD). Smoking and older age increased malignancy risk, while female sex and submandibular gland involvement were protec
Postoperative day 2 C-reactive protein under 100 mg/L effectively excludes anastomotic leakage with high negative predictive value, enabling earlier and safer discharge in colon cancer resection patients within ERAS protocols.
The Chinese Society of Colorectal Surgery consensus (Gut 2026) standardizes use of immune checkpoint inhibitors (ICIs) in locally advanced rectal cancer—diagnostics, perioperative strategies, organ preservation, safety and follow-up.
This review synthesizes evidence on disitamab vedotin combined with tislelizumab showing promising efficacy and safety in treating transurethrally unresectable ERBB2-positive very high-risk NMIBC, filling a crucial therapeutic gap for patie
