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CDK4/6 inhibitor therapy in hormone receptor-positive breast cancer is linked to increased corneal epithelial alterations, including punctate epitheliopathy and vortex keratopathy, independent of aromatase inhibitor effects or tear film dys
A secondary analysis of the RACC trial reveals robot-assisted radical hysterectomy reduces intraoperative complications but shows similar postoperative morbidity and modest quality-of-life benefits compared with open surgery in early-stage
MTFP1 promotes pancreatic ductal adenocarcinoma liver metastasis by enhancing mitochondrial oxidative phosphorylation via the ROS/PI3K/AKT/c-MYC/SLC1A5 axis, revealing a promising therapeutic target to reverse tumor immune suppression and r
Systemic relapse after stage I melanoma, though rare, portends higher tumor burden and poorer survival compared with relapse after stage II/III disease, as evidenced by data from 365 metastatic melanoma patients in the Spanish Melanoma Regi
This study uncovers molecular subtypes of salivary adenoid cystic carcinoma based on genomic and transcriptomic analyses, introducing a novel copy number variation (CNV)-based classification that improves prognostic accuracy and could refin
A large randomized trial assessing whether adding a blood-based multicancer early-detection test to usual care reduces late-stage cancer diagnoses found no significant difference in stage III or IV cancers but observed a trend toward fewer
A phase II trial shows that adding the bispecific antibody glofitamab to polatuzumab-R-CHP achieves a 95% complete response rate and durable remission with minimal cytokine release syndrome in high-risk diffuse large B-cell lymphoma.
This article reviews the KOMET-007 trial evaluating ziftomenib with venetoclax and azacitidine in relapsed/refractory NPM1-mutated AML, highlighting promising remission rates and manageable safety.
A randomized trial found no significant benefit of early specialist palliative care on end-of-life outcomes among patients undergoing curative abdominal cancer surgery, suggesting tailored rather than routine involvement.
Complete resection of the primary tumor significantly improves survival outcomes and reduces local progression without increasing surgical complications in high-risk neuroblastoma patients.
A landmark pan-European study confirms that a structured, simulation-based training program enables safe introduction of robotic pancreatoduodenectomy, improving surgeon skills and maintaining patient safety across diverse centers.
Lisocabtagene maraleucel shows sustained high remission rates and a favorable long-term safety profile in patients with heavily pretreated follicular lymphoma after three years of follow-up, including high-risk subgroups.
The SICE Liver ICG study demonstrated that indocyanine green fluorescence imaging significantly improves detection and margin assessment during minimally invasive, parenchymal-sparing liver resections for colorectal metastases, supporting m
This phase 1/2 study evaluates farletuzumab ecteribulin, a folate receptor alpha-targeting ADC, showing that fractionated dosing reduces interstitial lung disease risk and demonstrates preliminary antitumor activity in advanced ovarian, end
This review synthesizes recent evidence demonstrating persistent racial and ethnic disparities in treatment initiation and survival among patients with advanced endometrial cancer, highlighting the critical influence of socioeconomic status
FGF18 produced by stromal fibroblasts promotes AML progression via FGFR3-mediated AKT-mTOR signaling, forming a feed-forward loop that impairs CD8+ T-cell immunity. Neutralizing FGF18 synergizes with PD-1 blockade, suggesting a novel therap
This pooled analysis from COG studies reveals that after accounting for tumor biology, age, tumor nephrectomy weight, and diameter are not independently predictive of outcomes in stage I/II favorable histology Wilms tumor, refining risk str
Ocular proton therapy in uveal melanoma induces significant reductions in corneal nerve parameters with partial recovery by 12 months, while corneal sensitivity remains stable and patient-reported symptoms show limited correlation with stru
This study evaluates how clonal hematopoiesis of indeterminate potential (CHIP) and pre-treatment neutropenia affect clinical outcomes and toxicities in patients undergoing CAR-T therapy for hematologic cancers, revealing nuanced risks for
Emerging therapies have revolutionized first-line treatment in large B-cell lymphoma, but inconsistent trial designs and biomarker use create complexity. Harmonized strategies integrating biomarkers, pooled data, AI, and regulatory collabor
