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This article explores novel therapeutic strategies in acute myeloid leukemia by combining PI3K inhibitors with EZH1/2 dual inhibitors to overcome epigenetic resistance mechanisms in leukemic stem cells, offering promising pathways to preven
A randomized trial shows that a 6-week corticosteroid taper is superior to a 3-week taper for mild immune-related pneumonitis, establishing 6 weeks as the evidence-based standard for short-term treatment success.
Ocular proton therapy causes significant decreases in corneal nerve fiber parameters in uveal melanoma patients, with partial recovery by 12 months and minimal changes in corneal sensitivity and patient-reported outcomes.
The GLOW phase III trial demonstrates that fixed-duration ibrutinib-venetoclax provides superior overall survival, progression-free survival, and safety compared to chlorambucil-obinutuzumab in older/comorbid CLL patients, with durable dise
This large-scale study reveals that adolescent and young adult women with breast cancer predominantly undergo mastectomy and experience comparable perioperative outcomes to older women, despite a higher metastatic burden.
A study at The Ohio State Comprehensive Cancer Center reveals high rates of prolonged opioid use following radiation or chemoradiation in head and neck cancer patients, underscoring the need for tailored opioid stewardship.
A population-based cohort study in Sweden found that use of 5α-reductase inhibitors, which reduce bioactive testosterone, is associated with a 17% lower risk of laryngeal and hypopharyngeal squamous cell carcinoma in men, supporting the hor
This review synthesizes current evidence comparing enucleation and pancreatoduodenectomy for benign and low-grade malignant pancreatic head tumors, highlighting differential perioperative risks, long-term quality of life, and tumor-specific
A multicenter randomized clinical trial shows robotic-assisted minimally invasive esophagectomy yields higher lymph node clearance with comparable safety to conventional thoracolaparoscopic approaches for esophageal adenocarcinoma.
Medicaid expansion under the Affordable Care Act is associated with reduced mortality in patients under 65 diagnosed with colorectal cancer and synchronous liver metastasis, notably improving outcomes for those receiving surgical and system
Complete pathologic response (cPR) after locoregional therapies notably improves survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. Yttrium-90 radioembolization shows superior cPR rates, particularly when
Robotic-assisted minimally invasive esophagectomy (RAMIE) advances surgical treatment in esophageal cancer, offering improved outcomes and standardization, evaluated through the IDEAL Framework and supported by international registry data.
This study assesses the efficacy and safety of pembrolizumab combined with bevacizumab and oral metronomic cyclophosphamide in heavily pretreated platinum-resistant ovarian cancer patients, showing modest disease control with manageable tox
In a large, diverse cohort of women with endometrial cancer, 11.9% harbored pathogenic germline variants, including Lynch syndrome and homologous recombination deficiency-related mutations. Testing at diagnosis identified most Lynch syndrom
This study demonstrates that ovarian-sparing surgery in premenopausal patients with early-stage adult granulosa cell tumors offers survival outcomes similar to bilateral salpingo-oophorectomy, supporting fertility-preserving options in clin
TESERA leverages computational pathology to classify hepatocellular carcinoma into biologically distinct morphologic subtypes from standard H&E slides, offering accurate prognosis stratification competitive with clinical and molecular m
A 50-year-old woman with metastatic medullary thyroid carcinoma (MTC) lacking RET alterations exhibited a remarkable sustained response to selpercatinib, suggesting potential efficacy beyond RET-mutated cases.
The INTERCEPT study demonstrates that longitudinal ctDNA testing effectively detects minimal residual disease post-curative treatment in colorectal cancer, enhancing recurrence prediction and refining risk stratification to guide future int
This review synthesizes recent evidence on immune checkpoint inhibitor (ICI)-based downstaging therapy for hepatocellular carcinoma (HCC) beyond Milan criteria prior to liver transplantation, highlighting improved oncologic outcomes alongsi
A Nature Immunology study reports that tumor cells shed antigen-bearing migrasomes during migration, boosting CD8 T-cell responses and reducing metastasis in mice; human data remain descriptive and no vaccine has been tested in people.
