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Iatrogenic cerebral amyloid angiopathy (iCAA) exhibits high symptomatic intracerebral hemorrhage rates decades after exposure. This analysis of 82 European cases highlights recurrence risks and cognitive outcomes, informing prognosis and pa
The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive impr
National data show that Comprehensive Stroke Center status and trial participation independently predict reported stroke rates after TAVR, highlighting potential ascertainment bias affecting hospital performance metrics.
In acute ischemic stroke patients with excellent reperfusion, elevated peri-infarct microvascular heterogeneity measured by MRI predicts infarct growth and poor functional recovery, reflecting the no-reflow phenomenon despite restored macro
A retrospective cohort study reveals that shorter duration from migraine onset to trigger-site surgery predicts better postoperative headache frequency reduction, underscoring the benefit of early surgical intervention in medically refracto
This nationwide study reveals that hospitals with higher tendencies for early tracheostomy in severe TBI patients also show increased rates of withdrawal of life-sustaining treatment, highlighting significant practice variability and its po
This study evaluates shunt preservation strategies in adults with ventriculoperitoneal shunts undergoing emergency abdominal surgery, finding low infection rates and favorable outcomes with shunt retention.
This bicentric study evaluates quantitative pupillary light reflex (qPLR) alongside EEG, SSEPs, and NSE for neuroprognostication in comatose post-cardiac arrest patients, revealing strong correlations but limitations in sensitivity and pred
This study evaluates concordance between physician-assessed and patient-reported modified Rankin Scale scores in adults with chronic neurologic disorders in Zambia, revealing substantial agreement but highlighting cultural and symptomatic f
The LIMS study demonstrates sustained, modest improvements in MS-related functioning and dietary behavior up to 24 months following a digital multimodal lifestyle intervention, supporting lifestyle interventions as complementary to MS manag
This article reviews the development and validation of patient-reported outcome measures as interim endpoints in multi-arm multistage trials for progressive multiple sclerosis, highlighting their potential to accelerate therapeutic developm
This longitudinal study investigates plasma biomarker dynamics in Alzheimer’s patients treated with lecanemab, revealing distinct biomarker trajectories that reflect amyloid clearance, tau modulation, and immune responses, offering in
A large Ontario cohort study found that transient ischemic attack (TIA) significantly increases long-term dementia risk, rivaling stroke’s impact, underscoring the need for cognitive-focused prevention strategies.
Stroke incidence among young adults aged 20-54 is increasing despite a modest decline in 30-day fatality, linked to growing prevalence of vascular risk factors and substance use. This population-based study underscores urgent preventive nee
Atrial fibrillation density, reflecting temporal episode clustering, independently predicts ischaemic stroke risk and improves risk stratification beyond traditional AF burden metrics, enabling more precise stroke prevention strategies.
This study reveals persistent structural brain alterations and evolving psychiatric symptoms in post-acute NMDA receptor encephalitis, highlighting the need for focused long-term care and advanced imaging markers.
Left atrial mechanical dysfunction, particularly atrial electromechanical dissociation and impaired left atrial strain contraction, forecasts increased cerebrovascular events in transthyretin amyloid cardiomyopathy patients even in sinus rh
This article evaluates spinal MRI features in AQP4-IgG+ NMOSD myelitis, highlighting the diagnostic specificity of bright spotty lesions, the double-contoured LETM sign, and sagittal ring enhancement for differentiating NMOSD from other mye
This large-scale meta-analysis identifies specific brain structural alterations—mainly in cortical surface area and subcortical volumes—associated with bulimia nervosa diagnosis and symptom severity, advancing understanding of its neurobiol
This review synthesizes evidence on the relationship between antipsychotic choice after traumatic brain injury (TBI) and post-traumatic epilepsy risk in older adults, highlighting recent population-based findings and mechanistic implication
