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Damage to serotonergic and dopaminergic neurotransmitter-linked networks predicts variability in acute and chronic poststroke language impairment, offering new insights beyond traditional lesion metrics.
DWI-positive lesions in acute intracerebral hemorrhage patients correlate with cerebral small vessel disease markers and predict poorer 6-month outcomes, with lesion distribution varying by small vessel disease subtype.
A multiprotein plasma panel improves detection of advanced neocortical tau pathology in Alzheimer’s disease risk individuals beyond p-tau217 alone, enhancing patient stratification and clinical trial selection.
This multicenter study characterizes lesion growth variability in adult cerebral adrenoleukodystrophy, highlighting key MRI and biomarker predictors to guide personalized treatment and improve clinical trial designs.
The MINT trial demonstrates that inebilizumab markedly lowers exacerbation rates and rescue therapy use in AChR+ and MuSK+ generalized myasthenia gravis patients undergoing corticosteroid tapering.
The STATICH trial assessed safety and efficacy of antiplatelet therapy after intracerebral hemorrhage, revealing increased hemorrhagic risk but fewer ischemic events among treated patients, highlighting ongoing clinical dilemmas.
This article examines how age, traditionally considered a high-risk factor in lower-grade gliomas, influences prognosis and treatment decisions in the molecular era, highlighting the importance of IDH mutation status.
This review synthesizes evidence linking NOAC use to slower cognitive decline and improved clinical outcomes in patients with atrial fibrillation and Alzheimer’s disease, highlighting advantages over warfarin and non-use.
The ADAM Study demonstrates superior diagnostic accuracy of live cell-based assays over fixed cell-based and ELISA tests for detecting AChR antibodies in myasthenia gravis, highlighting important clinical implications for antibody testing s
An international study reveals that childhood trauma’s association with bipolar disorder is partially mediated by brain morphology changes, particularly in hippocampal volume and frontal cortical thickness.
This study presents a deep learning model that generates synthetic T-max perfusion maps from noncontrast DWI and FLAIR sequences, potentially streamlining stroke imaging and eliminating the need for contrast agents.
The ADAM study reveals that live and fixed cell-based assays outperform ELISA in detecting AChR and MuSK antibodies, offering enhanced diagnostic accuracy for myasthenia gravis, particularly in ocular cases.
This study analyzes clinicopathological and genetic correlations in Parkinsonian disorders across diverse ancestries, revealing diagnostic challenges, genetic influences, and ancestry-related pathological variations.
This large-scale longitudinal study reveals that chronic cough is linked with widespread grey matter volume reductions and accelerated brain atrophy, highlighting potential neurostructural underpinnings of cough hypersensitivity.
A phase IIb trial shows that adding normobaric hyperoxia to endovascular thrombectomy in acute ischemic stroke patients 6 to 24 hours after onset is safe, improves early neurological outcomes, and reduces infarct volume, warranting larger c
Brain-predicted age difference (brain-PAD) from MRI improves early dementia risk prediction in patients with subjective cognitive decline, outperforming traditional visual MRI ratings and offering prognostic value beyond amyloid biomarkers,
A randomized trial shows reperfusion-guided blood pressure management post-thrombectomy improves functional outcomes and reduces hemorrhagic transformation, supporting personalized BP targets based on reperfusion status.
This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.
This study investigates whether recurrent hospitalizations mediate the association of postoperative delirium with long-term cognitive decline in seniors after major surgery, finding that rehospitalization does not significantly affect this
This pilot randomized trial demonstrates the feasibility of using low-dose colchicine after acute intracerebral hemorrhage to prevent vascular events, highlighting considerations for future larger studies regarding recruitment, adherence, a
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