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The Vibrance-1 phase 2 trial demonstrates that once-daily oral alixorexton significantly improves wakefulness and reduces cataplexy in narcolepsy type 1, with a favorable safety profile supporting phase 3 evaluation.
This study identifies key nongenetic factors impacting disease onset and severity in hereditary ataxias SCA6 and SCA27B, highlighting environmental exposures and demographics as important modifiers beyond genetic mutations.
Cascade genetic screening in hereditary transthyretin amyloidosis (ATTRv) enables earlier diagnosis and intervention, improving survival and highlighting the need for variant-specific surveillance strategies.
This study explores how economic, educational, healthcare, neighborhood, and social factors link to multiple frailty dimensions in Chinese older adults, highlighting cognition as a key intermediary.
This study reveals how respiratory system elastance influences the effects of tidal volume and respiratory rate on outcomes in mechanically ventilated acute brain injury patients, suggesting personalized ventilation strategies based on resp
This study demonstrates that high-resolution 3D facial geometry captured via smartphone accurately and objectively quantifies facial nerve palsy severity, enabling continuous grading, early detection, and improved patient monitoring.
In pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), escalation of acute immunotherapy beyond steroids at first attack is linked to significantly fewer relapses within one year and mid-term follow-up, highli
Young survivors of aneurysmal subarachnoid hemorrhage face a lifelong risk of developing new aneurysms, with female sex, smoking, and family history as key risk factors. Smoking cessation reduces this risk, supporting need for lifelong surv
This study elucidates how escalating cognitive workload affects brain activation in novice surgical residents, revealing distinct neural patterns linked to performance resilience or decline during simulated suturing tasks.
This review synthesizes evidence on home-based cognitive training feasibility, adherence, and patient experiences in gynecologic cancer survivors with CRCI, highlighting clinical implications and directions for optimized intervention design
A randomized clinical trial comparing individualized versus standard blood pressure control during mechanical thrombectomy for ischemic stroke showed no significant difference in 90-day functional outcomes or safety.
This review synthesizes evidence on paternal valproate exposure and offspring neurodevelopmental risks, highlighting recent large cohort data that challenge prior concerns of increased neurodevelopmental disorders or congenital malformation
African adults with type 2 diabetes who are lean exhibit distinct complication profiles characterized by higher retinopathy and stroke risk but lower hypertension and cardiovascular disease risk compared to their overweight/obese counterpar
Clonal hematopoiesis (CHIP) significantly associates with increased silent brain lesions and progressive cognitive decline in atrial fibrillation patients, highlighting a novel neurovascular risk factor with implications for patient managem
Clinicians face multifaceted challenges during surgical decision-making for patients with dementia, including difficulties in dementia recognition, reliance on caregivers, and lack of evidence-based guidelines, underscoring the need for imp
This article explores the complex challenges clinicians face in surgical decision-making for patients with dementia, highlighting issues with dementia identification, caregiver roles, and the influence of dementia on surgical outcomes.
This study reveals that the characteristics of carotid plaque calcifications on CTA scans correlate with stroke symptoms beyond traditional stenosis severity, offering improved risk stratification for carotid artery disease.
A post hoc analysis of the BRIDGE-TNK trial reveals that intravenous tenecteplase before endovascular thrombectomy significantly improves functional independence in acute large-vessel occlusion stroke patients with extensive baseline ischem
Paramagnetic rim lesions detected via MRI are associated with increased risk of disability progression independent of relapse activity and accelerated brain atrophy in multiple sclerosis, highlighting their role as prognostic biomarkers for
This randomized trial demonstrates that adding virtual reality-based vestibular rehabilitation to home exercises significantly improves symptom severity and dynamic postural control in vestibular migraine patients.
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