Section
This study reveals that younger, non-Hispanic White patients with fewer comorbidities and lower socioeconomic vulnerability are more likely to receive antiamyloid medications for Alzheimer’s, while higher comorbidity predicts lower initial
A feasibility RCT demonstrates that a telehealth-delivered behaviour change intervention, augmented with a physical activity monitor, can increase physical activity in post-stroke individuals, supporting future large-scale trials.
MRI positivity in 52% of idiopathic acute unilateral audiovestibulopathy patients correlates significantly with vestibular deficits, particularly in the posterior canal, aiding diagnostic clarity and revealing pathophysiological insights.
A comprehensive meta-analysis of six US cohorts identifies vascular risk factors including smoking, hypertension, diabetes, chronic kidney disease, stroke history, and APOE ε4 genotype as significant predictors of late-onset epilepsy in old
A randomized controlled trial reveals that repetitive transcranial magnetic stimulation combined with vestibular rehabilitation significantly improves dizziness, balance, and postural stability in adults with chronic peripheral vestibular d
An international Delphi panel offers practical, evidence-informed recommendations for managing spontaneous intracranial hypotension with spinal longitudinal epidural CSF collections, clarifying peri-epidural blood patch practice, imaging ch
This study reveals significant hippocampal subfield volume reductions and white matter impairments in patients with congenital adrenal hyperplasia, highlighting sex-specific differences that could influence cognitive outcomes and treatment
This study evaluated whether 4 weeks of unilateral isometric elbow flexion resistance training induce adaptations in human reticulospinal tract function, finding no significant changes despite strength gains, thus informing neurorehabilitat
The ReCCLAIM II trial demonstrates that rapid systemic hypothermia during mechanical thrombectomy for large-vessel occlusion stroke is feasible without delaying reperfusion, showing trends toward reduced infarct volume but raising safety co
A 6-month longitudinal study identifies younger age, higher resilience, and better health literacy as key predictors of functional ability improvement in traumatic spinal cord injury patients, highlighting targets for tailored rehabilitatio
This study reveals that aggressive electrical stimulation during acute Bell’s palsy recovery may worsen synkinesis and reduce botulinum toxin efficacy, while chronic-phase stimulation improves function, emphasizing a critical cumulati
This study reveals that midlife plasma p-tau181 predicts faster memory decline over 11 years, highlighting a long prodromal phase of Alzheimer’s disease. Late-life biomarkers p-tau181, NfL, and GFAP correlate with accelerated cognitive decl
A large-scale UK cohort study found no strong associations between antibodies against multiple common infections and key Alzheimer’s disease neuropathologies, though possible interactions with APOE ε4 genotype and education warrant further
This study illuminates how APOE ɛ4 accelerates executive function decline while ɛ2 may protect verbal episodic memory in individuals aged 90+, highlighting genetic influences on cognition in exceptional longevity.
This review synthesizes global dementia incidence from the COSMIC consortium, highlighting variations by age, sex, and economic regions, with implications for prevention and resource planning, informed by recent meta-analyses on risk factor
Nationwide analyses show that epilepsy markedly increases the risk of young-onset dementia (YOD) before age 65, with persistent associations even years after epilepsy diagnosis, underscoring the need for YOD risk assessment in epilepsy care
This study evaluates the association between early pregnancy use of anti-CGRP monoclonal antibodies or propranolol and spontaneous abortion risk, finding increased risk with anti-CGRP mAbs but not with propranolol.
This review synthesizes evidence on spinal cord stimulation combined with physiotherapist-led exercise and physical activity prescriptions, highlighting sustained pain relief and quality-of-life improvements without significant increases in
Delpacibart zotadirsen demonstrates an acceptable safety profile and significant increases in exon 44 skipping and dystrophin expression in DMD patients amenable to exon 44 skipping, supporting further phase 3 evaluation.
The OCEANIC-STROKE randomized trial demonstrates that adding asundexian to antiplatelet therapy reduces ischemic stroke without a significant rise in major bleeding, though it increases lower gastrointestinal bleeding in patients with nonca
