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This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
A multicenter RCT demonstrates that 10-kHz spinal cord stimulation significantly improves pain relief, sensory function, and nerve fiber density in painful diabetic neuropathy, suggesting potential disease-modifying effects.
This study analyzes global trends comparing ischemic stroke burdens linked to diabetes and atrial fibrillation, revealing a rising impact of diabetes-related stroke and highlighting the need for targeted interventions.
This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson’s disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biologic
This study links MC1R loss-of-function variants to faster motor decline and phenoconversion in Parkinson’s disease, suggesting their value for prognosis and clinical trial design in European descent patients.
Secondary analysis of the TASTE trial reveals tenecteplase confers superior functional outcomes versus alteplase in patients with distal middle cerebral artery occlusions, supporting its use in more peripheral ischemic stroke territories.
This Finnish nationwide study demonstrates that patients with atrial flutter have a substantially lower risk of ischaemic stroke compared to those with atrial fibrillation, highlighting important differences in thromboembolic risk profiles
Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.
Accumulating evidence underscores how adverse social determinants of health (SDOH) from early adulthood heighten the risk of early-onset stroke, with dose-dependent effects and disparities by race and sex.
Pregnancy significantly reduces antiseizure medication concentrations, with lamotrigine showing the greatest decline. Polytherapy and body weight modulate these changes, underscoring the importance of individualized therapeutic drug monitor
This retrospective cohort study explores how immigration status influences ICU admission rates and length of stay among ischemic stroke patients in Ontario, revealing longer ICU stays for immigrants despite similar admission rates compared
TAPIS subgroup analysis reveals that ticagrelor-aspirin combined with thrombolysis may improve outcomes in moderate ischemic stroke patients with multiple acute infarcts, without increasing hemorrhage risk, suggesting infarct pattern as a p
Cilostazol promotes dural lymphatic remodeling and hematoma clearance post-ICH without increasing bleeding risk, representing a promising therapeutic strategy to improve neurological outcomes.
This study demonstrates that cerebrospinal fluid beta-amyloid peptides correlate with MRI markers of disease severity in probable cerebral amyloid angiopathy, suggesting CSF biomarkers provide a direct measure of vascular amyloid burden, in
This study reveals that central autonomic network alterations in temporal lobe epilepsy patients contribute to interictal cardiorespiratory dysfunction, potentially increasing SUDEP risk, and highlights connectivity changes post-surgery imp
A retrospective study found that postoperative prednisone tapering does not reduce delayed facial nerve palsy incidence following acoustic neuroma resection and carries a 10% risk of steroid-related side effects.
This study evaluates differential item functioning in the EQ-5D-5L questionnaire among acute ischemic stroke patients, revealing minimal impact of age-related biases on quality of life measurement across sex and treatment groups.
This article details how BCKDK, a hypoxia-induced kinase, disrupts branched-chain amino acid metabolism to worsen neuronal injury in cerebral ischemia, highlighting its potential as a novel therapeutic target.
Elevated plasma p-tau217 correlates with cognitive impairment and altered sleep microarchitecture in older adults with late-onset unexplained epilepsy, highlighting potential pathways linking neurodegeneration, epilepsy severity, and sleep
Longitudinal analysis of blood proteins reveals distinctive trajectories and associations with cognitive decline in adults with Down syndrome, shedding light on Alzheimer’s disease pathophysiology in this high-risk group.
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