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This large cohort study from the NCAA and Department of Defense Concussion Assessment, Research and Education (CARE) Consortium demonstrates that early use of over-the-counter (OTC) analgesics, including acetaminophen and NSAIDs, is associated with lower symptom severity and faster recovery after concussion in athletes.
Both timing and use of OTC analgesics influenced outcomes, with early initiation (within 2 days of injury) promoting a significantly quicker return to unrestricted play.



