Section
This study identifies key prognostic factors and proposes a graded prognostic assessment to stratify survival in patients with brain metastases from nonanaplastic follicular cell-derived thyroid carcinoma.
Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize reco
This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.
A 10-year-old with a midbrain ischemic lesion after craniopharyngioma resection developed mutism with features of both akinetic mutism and cerebellar mutism, suggesting a shared neurocircuitry that responded to methylphenidate.
A systematic review and meta-analysis of 18 RCTs found that high-intensity resistance training significantly improved leg press and extension strength in adults aged 50+ compared to low-moderate intensity, with similar effects on bone density and no significant difference in fall incidence or adverse events.
A secondary analysis of the INTERACT3 trial shows that younger adults (≤50 years) with intracerebral hemorrhage have lower mortality and disability but differ in risk factors and may benefit more from bundled care.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
Among older adults with incident dementia, Alzheimer disease and LATE-NC pathologies were independently linked to higher odds of receiving a timely diagnosis, while vascular pathology and Lewy bodies showed no significant association.
The phase 3b TEMPLE trial found that atogepant 60 mg once daily led to fewer discontinuations due to adverse events and better migraine reduction than topiramate over 24 weeks.
Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents....
A nationwide Danish study links prolonged residential road traffic noise exposure with increased Parkinson disease risk, highlighting the protective effect of having a quiet building facade.
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
Combining abdominal electrical stimulation with airway clearance improves cough strength, muscle thickness, and decannulation rates in tracheostomized patients with neurologic disorders, without impacting infection or diaphragm mobility.
A large retrospective study reveals a small but significant increase in CNS demyelination risk among patients treated with TNF-α inhibitors, varying by agent, with generally low absolute incidence.
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
A Bayesian network meta-analysis comparing FcRn inhibitors, C5 complement inhibitors, and CD19+ B-cell depletion therapies reveals comparable efficacy but varied safety profiles in generalized myasthenia gravis treatment, highlighting the n
A prospective study identifies impaired hearing and high systolic blood pressure as accessible clinical markers associated with silent cerebral infarcts in women after eclampsia, suggesting potential triage tools for neuroimaging and follow
A novel optically guided stroke model targeting the mediodorsal thalamus in mice revealed disruptions in sleep stability, thalamocortical oscillations, and working memory. Auditory stimulation during sleep restored these functions, undersco
Paired vagus nerve stimulation (VNS) combined with rehabilitation achieves significant and durable improvements in upper extremity function, participation, and quality of life up to two years after chronic ischemic stroke, highlighting its
IL-6 receptor blockade significantly reduces relapse rates in MOG antibody-associated disease, showing comparable efficacy to high-dose IVIG with a favorable safety profile, supporting its role in relapse prevention.
