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A retrospective cohort study reveals that stroke-related disability or mortality after ED discharge for dizziness is rare (0.04% incidence), with most lesions occurring in the anterior fossa. Findings underscore the need for targeted risk s
Endovascular thrombectomy (EVT) significantly improves 90-day functional outcomes in acute anterior cerebral artery occlusion stroke compared to standard medical management, without increasing hemorrhage or mortality risks, per the ORIENTAL
A UK Biobank study reveals that optimal sleep (6-8 hours) improves executive function and reduces dementia risk in focal epilepsy patients, with effects surpassing those in stroke patients. Nonoptimal sleep exacerbates cognitive deficits up
A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.
A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.
A real-world study reveals FCN/GCV combination therapy enhances 1-year survival in HHV-6B encephalitis post-CBT, particularly after neutrophil engraftment, compared to monotherapy. Findings underscore the need for tailored antiviral strateg
GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.
High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.
A study reveals significant variability in ALSFRS-R analysis methods across 45 ALS trials, impacting treatment effect estimates and increasing false-positive risks, with implications for clinical decision-making and drug development.
Long-term data from the ULTIMATE open-label extension study demonstrates sustained efficacy and safety of ublituximab in relapsing multiple sclerosis over five years, with significant reductions in relapse rates and disability progression c
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
In patients aged under 80 with ASPECTS 0-2, endovascular thrombectomy improved disability outcomes and reduced mortality versus medical care alone, challenging the idea that very large infarcts should automatically exclude treatment.
Resting-state MRI and PET data suggest that corticostriatal networks remodel across nigrostriatal degeneration in Parkinson disease, with posterior caudate hyperconnectivity preceding major motor decline and posterior putaminal disconnectio
In two large U.S. cohorts, greater adherence to healthy dietary patterns—especially DASH—was associated with less subjective cognitive decline and slightly better objective cognition.
A 16-week home-based trial combining testosterone with functional electrical stimulation and arm ergometry improved lean mass and corrected anemia in spinal cord injury patients, though aerobic capacity gains were not statistically signific
A landmark South Korean study of 2.8 million adults reveals that both elevated blood pressure and hypertension significantly increase dementia risk, particularly vascular dementia, with stronger effects observed in midlife adults and women.
This feasibility RCT demonstrates that contingent fMRI neurofeedback targeting the left supramarginal gyrus can improve reading comprehension in stroke survivors with aphasia, outperforming both healthy controls and non-contingent neurofeed
This longitudinal cohort study reveals that biomarker-based biological age, particularly KDMAge and PhenoAge residuals, significantly predicts progression of cerebral small vessel disease, including new lacunes and microbleeds, offering pot
A Brazilian autopsy study of 2,268 individuals reveals that female sex, APOE ε4 status, and African ancestry jointly influence amyloid pathology. Women showed 65% higher adjusted odds of neuritic plaques, and protective effects against amyl
The PINGS trial demonstrates that a 12-month nurse-led mobile health intervention significantly improves blood pressure control among Ghanaian stroke survivors, with 67% achieving target BP versus 43% in usual care. This pragmatic approach
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