Section
This review synthesizes evidence on staged, bilateral MRgFUS pallidothalamic tractotomy for Parkinson’s motor complications, highlighting demonstrated unilateral safety and modest bilateral efficacy with increased adverse events, unde
AI-enabled point-of-care EEG monitoring accurately measures seizure burden, showing a dose-dependent association with unfavorable clinical outcomes at discharge, highlighting its potential in critical care.
A pooled individual participant data meta-analysis demonstrates that Electromagnetic Network-Targeted Field (ENTF) neuromodulation significantly improves freedom-from-disability and reduces poststroke disability compared to sham treatment,
This study develops a comprehensive probabilistic atlas of brain function using extraoperative electrocortical stimulation mapping in epilepsy patients, revealing distributed and variable language and motor cortical organization beyond trad
This review examines the impact of traumatic brain injury on the accuracy of Alzheimer disease blood biomarkers, highlighting reduced diagnostic performance in TBI-affected populations and the implications for clinical interpretation.
Rare deleterious variants in FBN2 gene contribute to spontaneous spinal CSF leaks, expanding our understanding of connective tissue involvement and opening paths for genetic testing and tailored therapies.
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
Selective local management of mild traumatic brain injury with intracranial hemorrhage shows comparable safety and outcomes to transfer to level I trauma centers, reducing unnecessary patient transfers.
The left atrial to ventricular volume ratio (LA:LV ratio) emerges as a superior marker over left atrial volume index (LAVi) for atrial cardiopathy, showing stronger association with ischemic stroke risk, cognitive decline, and atrial fibril
Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as m
Machine learning analysis of brief patient-physician conversations using acoustic speech features can effectively screen for cognitive impairment in primary care settings, enabling scalable early detection.
Secondary analysis of the TEMPO-2 trial reveals that successful recanalization significantly improves 90-day functional outcomes in minor ischemic stroke patients with proven occlusion, with tenecteplase markedly enhancing recanalization ra
This study identifies global and cytotoxic cerebral edema subtypes in cerebral venous thrombosis as key determinants of poor functional outcomes and mortality, providing new avenues for early risk stratification and targeted adjunctive ther
This review synthesizes current evidence on CSF TMEM106B levels in FTLD, highlighting their associations with disease severity, genetic variants, brain atrophy, and clinical progression, emphasizing TMEM106B’s potential as a biomarker
This article explores how physicians determine stroke care goals for patients with disability or dementia, highlighting key challenges, decision factors, and the need for individualized, bias-aware approaches.
Higher parity in cognitively unimpaired postmenopausal women with positive β-amyloid status is linked to accelerated cognitive decline and hippocampal volume reduction, suggesting parity modulates resilience to Alzheimer’s pathology in prec
This review synthesizes evidence on the long-term survival, excess mortality, and health-related quality of life in patients after chronic subdural hematoma surgery, emphasizing sustained mortality risks and cognitive-physical deficits up t
A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
The PSRS showed good-to-excellent reliability and moderate-to-strong construct validity in a large RBD cohort, supporting its use as a multidomain measure of prodromal synucleinopathy burden.
