Section
This study evaluates large language model (LLM) performance for predicting same-day hospital discharge, identifies primary error sources, and demonstrates that automated prompt optimization significantly improves predictive accuracy.
This study evaluates trauma-informed care (TIC) knowledge, attitudes, and practices among medical students and clinical instructors, revealing differences linked to training stages and lived adversity, highlighting opportunities for improve
Butyrylcholinesterase (BuChE) modulates hepatic stellate cell activation by degrading acetylcholine, mitigating fibrogenesis via muscarinic receptor signaling and offering a new therapeutic target for liver fibrosis.
Declines in frailty, intrinsic capacity, and physical quality of life occur years before cardiovascular events, highlighting a prolonged window for early intervention in older adults.
This study employs Item Response Theory to reveal that while overall communication scores in virtual and in-person OSCEs are similar, specific communication items like explaining jargon differ in proficiency thresholds across modalities, un
This article evaluates strategies for interpreting consecutive aldosterone-to-renin ratio tests in primary aldosteronism diagnosis, highlighting the diagnostic trade-offs and guiding clinical decision-making based on discordant or concordan
Extremely high NT-proBNP levels in hospitalized patients often indicate infection rather than heart failure, with a high mortality risk; interpretation requires comprehensive clinical context.
This qualitative study explores how internal medicine clinicians develop skills in discussing goals of care, revealing a progression from basic understanding to advanced, integrated communication approaches, and underscores the need for str
A concise, clinician-friendly summary of the 2026 VA/DoD guideline for treating tobacco and nicotine use, focusing on evidence-based pharmacotherapy, counseling, and new recommendations for electronic and smokeless products.
This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.
Between 2015 and 2025, non-cystic fibrosis bronchiectasis prevalence in the US primary care population increased by 133%, predominantly affecting older, white, female patients with Medicare coverage.
This statewide cohort study reveals significantly higher incidence and earlier onset of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar disorders compared to matched controls, highlighting urgent needs f
A nationwide survey of hospitalists reveals varied beliefs regarding treatment thresholds and approaches for asymptomatic elevated blood pressure in hospitalized patients, highlighting clinical uncertainty and practice variation.
A large-scale EHR study reveals a 133% increase in non-cystic fibrosis bronchiectasis prevalence in U.S. adults from 2015 to 2025, with marked demographic disparities.
Escalation of antihypertensive treatment in expectant management of early-onset preeclampsia with severe features correlates with increased maternal adverse outcomes, suggesting treatment trajectory as a dynamic risk indicator.
This qualitative study explores barriers and facilitators to implementing medical-legal partnerships (MLPs) for veterans experiencing intimate partner violence (IPV) within the Veterans Health Administration, highlighting critical organizat
The LiveSMART trial demonstrates that lactulose, with or without sequential TeleTai-Chi, significantly reduces fall risk and related harms in cirrhotic patients without prior overt hepatic encephalopathy.
A recent double-blind, placebo-controlled trial found that non-enteric-coated pancreatic enzyme therapy does not significantly reduce pain in chronic pancreatitis patients, highlighting the need to revisit pain management strategies in this
A cluster-randomized trial demonstrates that integrating best practice advisories (BPAs) and standing orders into electronic health records significantly improves referral rates to diabetes self-management education and support (DSMES) over
A novel educational model embedding clinical research training within real-world trials improves medical students’ research skills, fosters evidence-based thinking, and bridges clinical and academic integration.
