Section
An expert-practice summary of the 2026 AASLD EXPO on liver biopsy: indications, techniques (percutaneous, transjugular, EUS-guided), sample adequacy, safety thresholds, and emerging applications including molecular profiling and digital pat
Saroglitazar significantly improves liver fat content, liver enzymes, and lipid profiles in women with PCOS and MASLD, highlighting its potential as a therapeutic option in this underrepresented population.
The NEONIPIGA phase 2 trial demonstrates durable survival and high pathological complete response rates with neoadjuvant nivolumab and ipilimumab in localized MSI-high gastric and GEJ adenocarcinoma, highlighting potential for organ-preserv
The RESOLVE trial demonstrates that 8 weeks of sofosbuvir-velpatasvir treatment is non-inferior to the standard 12-week regimen in treatment-naive, non-cirrhotic chronic hepatitis C patients, supporting shorter treatment duration without co
This study demonstrates that nucleos(t)ide analogue therapy significantly reduces cirrhosis and hepatocellular carcinoma risk in specific HBeAg-positive chronic HBV infection phases beyond current EASL 2025 treatment indications.
This phase 2b trial demonstrates that oral icotrokinra, targeting the interleukin-23 receptor, significantly improves clinical outcomes in moderate to severe ulcerative colitis compared to placebo.
Pegylated interferon-alpha after nucleos(t)ide analog withdrawal induces coordinated expansion of regulatory B cells and contraction of HBV-specific T cells, impacting viral control and hepatic inflammation in HBeAg-negative chronic hepatit
A study in asymptomatic first-degree relatives of Crohn’s disease patients defines preclinical stages using faecal calprotectin, offering a targeted screening approach to enrich prevention trial cohorts.
A randomized controlled trial showed that preoperative botulinum toxin injection into the sphincter of Oddi does not reduce the incidence of clinically relevant postoperative pancreatic fistula following distal pancreatectomy.
Identification of a pathogenic E. coli strain overexpressing HtpG that promotes fibrosis in chronic pancreatitis via macrophage-mediated pathways highlights new microbiota-targeted treatment avenues.
Prolonged donor warm ischemia during pure laparoscopic donor right hepatectomy elevates recipient biliary stricture risk, underscoring the need to minimize warm ischemic time for better post-transplant outcomes.
An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combin
This article explores how the zinc-dependent RNA-binding protein ZFP36L1 controls hepatocyte senescence and influences recovery from alcohol-related liver failure by modulating key mRNAs, highlighting its potential as a therapeutic target i
The Chinese Society of Colorectal Surgery consensus (Gut 2026) standardizes use of immune checkpoint inhibitors (ICIs) in locally advanced rectal cancer—diagnostics, perioperative strategies, organ preservation, safety and follow-up.
Continuous glucose monitoring-guided insulin optimization improves glycemic control and nutritional status in insulin-treated adults receiving long-term nocturnal parenteral nutrition, reducing hyperglycemia and associated complications.
MTFP1 promotes pancreatic ductal adenocarcinoma liver metastasis by enhancing mitochondrial oxidative phosphorylation via the ROS/PI3K/AKT/c-MYC/SLC1A5 axis, revealing a promising therapeutic target to reverse tumor immune suppression and r
This analysis of over 63,000 US liver transplants reveals that simultaneous liver-kidney transplantation (SLKT) confers significant survival benefit only in patients with severe renal dysfunction (eGFR <30), with no advantage in those wi
This study identifies a learning curve in robotic gastroenterostomy during robotic pancreatoduodenectomy and shows that better surgical performance reduces delayed gastric emptying risk, suggesting OSATS scoring as a valuable training tool.
Intestinal inflammation disrupts gut microbial metabolism of dietary antigens, promoting food sensitization and mast cell–mediated adverse reactions, which may explain frequent food intolerances in IBD patients.
This international multicenter study reveals low immediate mortality after pediatric first variceal hemorrhage, with outcomes strongly influenced by underlying diagnosis, disease severity, and center-specific practices.
