Section
This review synthesizes evidence on return to competition and career sustainability after ACL reconstruction in football, highlighting variable return rates by competitive level, persistent long-term participation challenges, and multifacto
This review explores barriers and facilitators influencing research participation among Black and Hispanic/Latino(a) individuals with cystic fibrosis (CF), highlighting systemic inequities, racialized experiences, and community-centered sol
Quadriceps strength recovery after ACL reconstruction exhibits three distinct trajectories linked to preoperative strength and meniscectomy status, yet these trajectories do not correlate with postoperative clinical outcomes at one year.
Fractional doses (one-fifth and one-half) of 17DD yellow fever vaccine demonstrate non-inferior immunogenicity and comparable safety to full doses in children aged 9–23 months, supporting dose-sparing strategies during vaccine shortages.
This review synthesizes evidence linking tele-critical care with interhospital transfer patterns and outcomes, highlighting improved transfer selection and reduced low-value transfers among critically ill Medicare patients.
The INTERVENE trial reveals that adding midostaurin to low-dose cytarabine and venetoclax is tolerable and improves FLT3-ITD clearance and survival in older AML patients with FLT3-ITD, addressing resistance in this high-risk subgroup.
Lonvoguran ziclumeran, an in vivo CRISPR-based single-dose gene-editing therapy, significantly reduces hereditary angioedema attacks and demonstrates a favorable safety profile, marking a transformative advance in treatment.
Recent evidence highlights the prognostic significance of body composition metrics, including BMI, skeletal muscle mass, and adiposity distribution, in head and neck cancer radiotherapy outcomes. Automated 3D CT phenotyping refines risk str
Genetic variants in dilated cardiomyopathy confer differential arrhythmic risks, independent of traditional clinical parameters. Integrating recent registry data and molecular studies enhances risk stratification and informs tailored manage
A comprehensive review of the ACHIEVE-4 trial confirms orforglipron’s cardiovascular safety non-inferior to insulin glargine in type 2 diabetes patients at elevated cardiovascular risk, highlighting its oral administration and safety
This review synthesizes evidence linking routine vaccinations, including COVID-19 and herpes zoster vaccines, with reduced risk of new-onset idiopathic uveitis, highlighting immune mechanisms and clinical impacts.
This review synthesizes evidence supporting outpatient management of acute low-risk pulmonary embolism (PE), highlighting risk stratification tools, safety outcomes, and implementation strategies to enhance adoption in clinical practice.
This review evaluates evidence linking perioperative cannabis use to prolonged opioid use and functional outcomes in head and neck cancer patients undergoing free flap reconstruction, emphasizing implications for pain management.
This review synthesizes global dementia incidence from the COSMIC consortium, highlighting variations by age, sex, and economic regions, with implications for prevention and resource planning, informed by recent meta-analyses on risk factor
This review synthesizes phase 2 trial data supporting neoadjuvant stereotactic ablative radiotherapy for RCC with IVC tumor thrombus, highlighting improved recurrence-free survival, acceptable safety, and biomarker insights that underscore
This review critically examines the SAVE-ICU trial assessing isoflurane inhaled sedation versus intravenous sedation in mechanically ventilated adults with acute hypoxemic respiratory failure, highlighting implications for clinical practice
This review synthesizes evidence evaluating the Epic Pediatric Sepsis Early Detection Model (PESM), highlighting its low sensitivity for early sepsis identification, disparities in performance across demographics, and implications for clini
This review synthesizes evidence on GLP-1 receptor agonist initiation impacting psychiatric hospitalisation and emergency visits in adults with schizophrenia and type 2 diabetes, highlighting metabolic and psychiatric interplay and therapeu
This review synthesizes current evidence on high-frequency chest wall oscillation (HFCWO) for airway clearance in acute respiratory failure with bronchial hypersecretion, highlighting recent RCT findings, mechanistic insights, and future re
Corrective lens spending affects nearly 20% of the US population, with half paying fully out-of-pocket, highlighting substantial financial burdens and access barriers. Evidence from clinical trials and epidemiologic studies underscores cost
