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In frail elderly Asian AF patients stable on warfarin, transitioning to DOACs increased risks of bleeding, thromboembolic events, and mortality, emphasizing cautious individualized management.
Emerging evidence indicates that radiation dose to the left anterior descending coronary artery better predicts cardiac events than whole-heart dose in breast radiotherapy, emphasizing the importance of LAD-based planning to reduce long-ter
This review synthesizes evidence linking neuroretinal layer thinning observed by OCT with glycemic control and diabetic retinal disease in youth with type 1 diabetes, emphasizing early neurodegeneration preceding vascular changes and its po
This review synthesizes evidence on factors influencing delays in postoperative radiotherapy for head and neck cancer in rural settings, emphasizing communication, coordination, and community resources to inform strategies that improve care
This review synthesizes current evidence on the modified sleep apnea severity index (mSASI) as a composite metric integrating clinical and sleep study factors to predict cardiovascular risk in CPAP-intolerant OSA patients undergoing surgery
This review synthesizes current evidence linking adverse childhood experiences with increased risk and features of PCOS, highlighting possible neuroendocrine mechanisms and clinical implications for reproductive health management.
This review synthesizes evidence on the lower prevalence and fulfillment rates of postpartum permanent contraception requests among incarcerated individuals compared to community counterparts, underscoring reproductive justice and health eq
This review examines the impact of traumatic brain injury on the accuracy of Alzheimer disease blood biomarkers, highlighting reduced diagnostic performance in TBI-affected populations and the implications for clinical interpretation.
This review synthesizes evidence on neurofilament light chain (NFL) as a minimally invasive plasma biomarker predictive of diabetic retinopathy progression and vascular complications, based on integrated intraocular-plasma proteomics and mu
This review synthesizes evidence from a pioneering nonrandomized trial demonstrating that intravenous AAVrh.10hFXN gene therapy is safe and may improve cardiac outcomes in Friedreich ataxia cardiomyopathy, highlighting translational advance
This review synthesizes evidence on swallowing function and perioperative complications following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC), highlighting excellent short-term swallowing outcomes and
Pregabalin, a neuromodulator, significantly improves symptoms in the majority of patients with chronic neurogenic cough, offering a well-tolerated treatment option irrespective of gender or gastrointestinal comorbidities.
This review synthesizes evidence on preS1 antigen and anti-preS1 IgG dynamics in chronic hepatitis B, highlighting their correlations with viral replication, liver inflammation, and functional cure, and elucidates the neutralising potential
The MAPLE-HCM trial demonstrates aficamten monotherapy significantly outperforms metoprolol in improving exercise capacity, hemodynamics, and patient-reported outcomes in obstructive hypertrophic cardiomyopathy (oHCM), supporting aficamten
This review synthesizes current evidence on CSF TMEM106B levels in FTLD, highlighting their associations with disease severity, genetic variants, brain atrophy, and clinical progression, emphasizing TMEM106B’s potential as a biomarker
This review synthesizes 20 years of data on pediatric hyperthyroidism, highlighting shifts toward prolonged antithyroid drug therapy, reduced definitive treatments, and rising relapse rates, underscoring the need for individualized long-ter
Analyzing 54 million adults in England reveals rising obesity rates from 2019-2025, disproportionately affecting socioeconomically deprived, ethnic minority, and younger adult groups, with widening inequalities intensified during the COVID-
This review synthesizes recent advances in understanding the natural history of LMNA-related cardiomyopathies and introduces the first validated prediction model for severe heart failure events, enhancing early risk stratification and manag
Genetic variants enriched in individuals of African ancestry confer increased risk of cardiomyopathy and arrhythmias, with cardiovascular risk factors amplifying this risk. Large biobank studies enable reclassification of key variants and h
This review synthesizes evidence comparing carbon footprints of VR, online, and alternative distance education in professional medical training, highlighting substantial CO2 emission reductions with digital modalities.
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