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The SMART-REACH2 model estimates lifetime recurrent cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease, offering region-specific recalibration and supporting personal
This study examines characteristics and reasons behind non-attendance to exercise and self-management sessions among multimorbid patients, highlighting younger age, lower self-efficacy, and depressive symptoms as key factors.
Integrated proteomic and metabolomic profiling of TMJ disease reveals nonlinear progression, molecular heterogeneity, and identifies distinct subtypes, offering a new framework for precision diagnosis and targeted therapies.
A comprehensive nationwide cohort study reveals that autograft type is not linked to revision ACL reconstruction risk in football players, with age and pre-injury playing level being stronger predictors. Notably, quadriceps tendon grafts in
The phase 3 VISIONARY trial establishes sibeprenlimab as a promising therapy in IgA nephropathy, significantly stabilizing eGFR decline and reducing kidney-function deterioration over 24 months with a favorable safety profile.
This article reviews evidence supporting OCT measurements of retinal layers as biomarkers for predicting multiple sclerosis progression and highlights the need for further research to enhance clinical application.
This study identifies preoperative apnea-hypopnea index as a key predictor of tonsillectomy success in children with obstructive sleep apnea, highlighting that surgery alone may be insufficient for severe cases.
This review synthesizes evidence on the incremental predictive value of task-specific kinematic performance data combined with preoperative clinical variables for robotic surgery outcomes and surgeon experience prediction.
This trial reveals that IVF significantly improves live birth rates compared to surgery in women with ultrasound-diagnosed deep or ovarian endometriosis-related infertility.
This article explores how dietary alginate fiber enhances mucosal healing through a microbiota-driven taurine pathway, evidenced by preclinical models and translational clinical insights in ulcerative colitis.
A Swedish cohort study reveals increased risk of inflammatory bowel disease in relapsing-remitting multiple sclerosis patients treated with rituximab compared to other therapies and the general population, underscoring the need for gastroin
Menopausal hormone therapy remains the most effective treatment for estrogen deficiency symptoms, with a favorable benefit-risk profile when individualized by age, timing, and formulation. Emerging evidence refines safety perceptions, guidi
This article evaluates the presence of micro- and nano-plastics in coronary blood of patients with ischemic heart disease, linking their burden to acute coronary events, air pollution exposure, and inflammation, highlighting a novel environ
A Swedish registry-based study reveals that 62% of athletes with high preinjury activity levels return to similar sports within a year after ACL reconstruction, with factors such as sex, age, and psychological readiness affecting outcomes.
A cross-sectional study used latent profile analysis to identify distinct quality of life outcome profiles in rehabilitation patients with traumatic brain injury, spinal cord injury, stroke, and limb injuries, highlighting heterogeneous pat
This study examines how prenatal exposure to endocrine-disrupting chemicals like phthalates and bisphenol A correlates with hypomineralized second primary molars (HSPM) in children, revealing sex-specific effects and emphasizing the impact
Interim analysis of a phase 3 trial demonstrates povetacicept’s efficacy in reducing proteinuria and pathological markers in IgA nephropathy, with a favorable safety profile.
This secondary analysis of the SirPAD trial shows that sirolimus-coated balloon angioplasty significantly reduces 1-year target-lesion revascularization rates compared to uncoated balloons in femoropopliteal artery disease patients without
The I-SPY2.2 trial evaluated rilvegostomig combined with trastuzumab-deruxtecan in high-risk ERBB2-negative early breast cancer, showing promising pathologic complete response rates in immune-positive tumors while reducing exposure to anthr
This study identifies a distinct, more horizontal posterolateral ACL bundle orientation associated with osteochondritis dissecans in the lateral femoral condyle, suggesting a potential anatomical factor influencing lesion pathogenesis and h
