Section
Emerging evidence reveals gut microbiota profiles correlate with disease severity and survival in idiopathic pulmonary fibrosis, highlighting potential microbial biomarkers and treatment modifiers.
This review synthesizes evidence demonstrating that continuous glucose monitoring (CGM) metrics, particularly time above 140 mg/dL, predict progression to stage 3 type 1 diabetes with accuracy comparable to oral glucose tolerance test (OGTT
This review synthesizes recent evidence demonstrating persistent racial and ethnic disparities in treatment initiation and survival among patients with advanced endometrial cancer, highlighting the critical influence of socioeconomic status
This review synthesizes evidence on dual antiglutamate therapy combining AMPA and NMDA receptor blockade in postanoxic super-refractory status epilepticus, highlighting the SUPER-CAT study’s demonstration of improved seizure resolutio
Plasma pTau217 levels measured by Lumipulse G assays strongly correlate with postmortem temporal cortex pTau217 pathology, supporting plasma pTau217 as a reliable biomarker for brain tau pathology in Alzheimer disease.
Continuous ocrelizumab treatment over 10 years in relapsing MS significantly delays disability progression, reduces relapse rates, and maintains a favorable safety profile, underscoring the clinical benefit of early high-efficacy therapy.
A prospective cohort study reveals a lower-than-expected prevalence of uterine fibroids among reproductive-aged Latina women in the US, highlighting age-related risk and associations with reproductive factors.
Early disclosure of plasma p-tau217 and NfL biomarkers significantly improves diagnostic confidence and clinical decisions in cognitive decline without increasing emotional distress, supporting their integration into routine memory clinic c
This review synthesizes evidence from the ELEVATE trial on adding cusatuzumab, a CD70-targeting antibody, to venetoclax with or without azacitidine in unfit AML patients, highlighting therapeutic potential, safety concerns, and translationa
This review synthesizes emerging evidence comparing high-dose anti-CD25 (without methotrexate) versus low-dose anti-CD25 (with methotrexate) strategies for GVHD prophylaxis in haplo-HSCT, highlighting improved acute GVHD control and GRFS wi
Sputum eosinophilia is linked to increased asthma-specific health services use, while neutrophilic inflammation drives hospitalizations in COPD. Understanding these inflammatory patterns aids personalized management and resource planning.
This review synthesizes evidence on clinical and biological factors linked to discordance between plasma p-tau217 and standard AD biomarkers, highlighting implications for diagnosis, patient stratification, and future biomarker development.
Early rapid optic nerve head swelling in NAION correlates with worse visual outcomes, with OCT measures of pONHV and mGCIPL thinning providing prognostic insights within days of symptom onset.
This review synthesizes longitudinal OCT findings and clinical outcomes in NAION, highlighting the prognostic value of early optic nerve head swelling rates for visual impairment progression, and discusses mechanistic and translational impl
This review synthesizes evidence on racial disparities in prehospital trauma care, examining intervention rates, the influence of social determinants, and mortality outcomes with a focus on recent cohort data.
This review synthesizes current evidence comparing enucleation and pancreatoduodenectomy for benign and low-grade malignant pancreatic head tumors, highlighting differential perioperative risks, long-term quality of life, and tumor-specific
Complete pathologic response (cPR) after locoregional therapies notably improves survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. Yttrium-90 radioembolization shows superior cPR rates, particularly when
Early continuous creatinine changes within 48 hours after EVT correlate with graded risks of poor 90-day functional outcome and in-hospital mortality, revealing prognostic nuances beyond traditional dichotomous CA-AKI definitions.
This review synthesizes evidence linking in utero exposure to preexisting and gestational diabetes with increased diabetes incidence in offspring, highlighting stronger effects among First Nations populations and the mitigating role of peri
Most heart failure patients harbor multiple cardiovascular-kidney-metabolic conditions, which independently escalate mortality and readmission risk, especially in HFrEF, underscoring the need for integrated management strategies tailored by
