Section
This review synthesizes evidence from large cohort studies and meta-analyses highlighting bariatric surgery’s association with reduced risks of many obesity-related cancers, consistent across age and sex. Mechanistic insights and impl
This review synthesizes evidence on spinal cord stimulation combined with physiotherapist-led exercise and physical activity prescriptions, highlighting sustained pain relief and quality-of-life improvements without significant increases in
This review synthesizes current evidence on pulse versus nonpulse corticosteroid therapy in AE-IPF, contextualizing the SAFER trial findings within prior studies and clinical guidelines to guide management and future research.
This review synthesizes evidence comparing laparoscopic radiofrequency ablation and myomectomy for uterine leiomyomata, highlighting higher treatment failure rates with RFA and identifying predictive factors influencing outcomes.
Delpacibart zotadirsen demonstrates an acceptable safety profile and significant increases in exon 44 skipping and dystrophin expression in DMD patients amenable to exon 44 skipping, supporting further phase 3 evaluation.
This review synthesizes evidence on the feasibility, acceptance, and clinical outcomes of pulmonary telerehabilitation models in COPD, highlighting technical reliability, patient adherence, and clinical benefits from recent trials, includin
The LATA trial demonstrates that long-acting injectable cabotegravir-rilpivirine given every 8 weeks is superior to daily oral ART for maintaining virological suppression in adolescents with HIV in sub-Saharan Africa, with a favorable safet
This review synthesizes evidence on racial and ethnic differences in plasma phosphorylated tau 217 (%p-tau217) in preclinical Alzheimer disease, highlighting implications for diagnostic screening and biomarker validity across diverse popula
Survodutide, a dual glucagon and GLP-1 receptor agonist, demonstrates significant weight loss and glycemic improvements in adults with obesity and type 2 diabetes, offering promise as a novel therapeutic agent with favorable efficacy and sa
More than one-third of Hispanic/Latino adults with diabetes exhibit diabetic retinopathy (DR), with significant variability across backgrounds. Hypertension notably associates with DR and vision-threatening DR, highlighting the need for tar
The twiist AID system significantly improves glycemic control and patient satisfaction in insulin-treated type 2 diabetes over 13 weeks, demonstrating safety and effectiveness supported by complementary real-world and RCT data.
Office-based vergence/accommodative therapy with movement (OBVAM) significantly improves accommodative amplitude and facility in adolescents and young adults with concussion-related convergence insufficiency, accelerating recovery and funct
Poor food access correlates with higher MASLD and frailty prevalence in liver transplant candidates, with geospatial clustering highlighting socioeconomic and environmental determinants impacting transplant candidacy and outcomes.
This review synthesizes recent evidence on US mental health and substance use disorder expenditures, highlighting distribution by disorder, service type, and sociodemographic factors, and discusses research and policy directions to optimize
This review synthesizes evidence on medical interpreters’ critical roles in supporting resilience for non-English language preference patients during ambulatory diagnostic care, highlighting gaps and implications for AI interpretation
This review synthesizes evidence on disitamab vedotin combined with tislelizumab showing promising efficacy and safety in treating transurethrally unresectable ERBB2-positive very high-risk NMIBC, filling a crucial therapeutic gap for patie
This review synthesizes evidence on the derivation and validation of a claims-based algorithm for identifying cardiogenic shock (CS), demonstrating its high diagnostic performance and enabling robust large-scale epidemiologic and long-term
This review synthesizes evidence on women Veterans’ emergency care utilization, comparing VA and Community ED use. It highlights demographic and clinical predictors influencing care settings and underscores the need for tailored coord
Ondansetron, a 5-HT3 antagonist, reduces respiratory drive in ARDS patients on mechanical ventilation by attenuating pulmonary C-fiber mediated stimulation, potentially lessening lung injury and improving oxygenation.
This review synthesizes evidence on how individual patient characteristics modify the comparative effects of cefepime versus piperacillin-tazobactam on acute kidney injury and neurologic outcomes in adults hospitalized with acute infection.
