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Clinical Updates

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Rehabilitation Medicine

Enhancing Post-Stroke Dysphagia Rehabilitation: Impact of Bimodal Signal Biofeedback on the Supraglottic Swallowing Maneuver

A randomized controlled trial demonstrates that bimodal biofeedback using accelerometer and nasal airflow sensors significantly improves swallowing function in post-stroke dysphagia patients undergoing supraglottic swallowing training.

Oct 30, 2026
Dentistry

Dynamic Changes in Salivary Extracellular Vesicles Post Non-Surgical Periodontal Therapy: A Novel Window into Periodontitis Treatment Response

This study reveals that six months of non-surgical periodontal therapy significantly modulates host and microbial extracellular vesicles in saliva, highlighting their potential as non-invasive biomarkers for monitoring periodontitis treatme

Oct 30, 2026
Nephrology

Ravulizumab in IgA Nephropathy: Interim Phase 3 Trial Analysis and Translational Insights

Ravulizumab, a terminal complement C5 inhibitor, significantly reduces proteinuria in adults with IgA nephropathy, demonstrating safety and biomarker improvements in phase 2 and 3 trials, highlighting its therapeutic potential.

Oct 30, 2026
Ophthalmology

Noncombustible Nicotine or Tobacco Product Use After Smoking Cessation and Major Vision-Impairing Diseases: Evidence from a Nationwide Cohort Study and Clinical Implications

This review synthesizes current evidence on the association between switching from combustible cigarettes to noncombustible nicotine/tobacco products and the risk of major vision-impairing eye diseases, highlighting a nationwide Korean coho

Oct 29, 2026
Otorhinolaryngology

Advancing Inner Ear Imaging: A Synchrotron-Based Deep Learning Network Outperforms Expert Segmentation in Clinical CT Scans

A novel deep learning network trained on synchrotron imaging data automates accurate inner ear segmentation in clinical CT, surpassing expert performance and establishing a new standard for preoperative planning.

Oct 29, 2026
General Surgery

KRAS Mutations in Duodenal Lavage Fluid After Secretin Stimulation: A Novel Biomarker for Early Detection of Pancreatic Cancer

Emerging evidence demonstrates that KRAS mutation analysis in secretin-stimulated duodenal lavage fluid offers a minimally invasive and sensitive approach for early detection of resectable pancreatic ductal adenocarcinoma, outperforming tra

Oct 29, 2026
Neurology

Determinants and Outcomes of Vessel Recanalization Following Acute Cervical Artery Dissection: Insights from an International Multicenter Cohort

This multicenter study reveals that nearly 60% of cervical artery dissection patients achieve complete vessel recanalization at 6 months. Older age, diabetes, smoking, and initial complete occlusion markedly reduce recanalization odds, with

Oct 29, 2026
Diabetes & Endocrinology

Predicting Type 2 Diabetes Remission and Relapse After Metabolic-Bariatric Surgery and Lifestyle Therapy: Insights from the ARMMS-T2D Study

The ARMMS-T2D study identifies key baseline factors predicting remission and relapse of type 2 diabetes after metabolic-bariatric surgery or intensive medical-lifestyle therapy, aiding personalized treatment decisions.

Oct 29, 2026
Rehabilitation Medicine

Mid-Term Outcomes of Combined Endoscopic Gluteus Medius/Minimus and Arthroscopic Labral Repair: A Propensity-Matched Analysis

This study evaluates five-year outcomes comparing combined endoscopic gluteal tendon and labral repairs versus isolated labral repair, showing comparable patient-reported outcomes and reoperation-free survival despite greater initial abduct

Oct 29, 2026
Rehabilitation Medicine

Community-Based Exercise and Chronic Pain Management in Spinal Cord Injury: Insights from a Pragmatic Randomized Controlled Trial

A pragmatic RCT suggests that exercise following spinal cord injury guidelines may reduce chronic pain intensity, with significant benefits observed in pain interference and coping strategies.

Oct 29, 2026
Neurology

Unraveling Racial Disparities in Functional Recovery After Ischemic Stroke: Insights from a Longitudinal Cohort Study

This study reveals persistent worse functional outcomes after ischemic stroke among Black patients, largely influenced by stroke severity, premorbid health, and social determinants, highlighting targets for intervention during recovery.

Oct 29, 2026
Diabetes & Endocrinology

Genomic Landscapes Distinguish Clinical Profiles of Cushing Disease and Silent Corticotroph Adenomas

This study elucidates distinct genetic drivers underlying Cushing disease versus silent corticotroph adenomas, revealing mutation and copy-number variation profiles that correlate with their divergent clinical behaviors and aggressiveness.

Oct 29, 2026
Hematology-Oncology

Rapid Peak Cilta-Cel Expansion Predicts Delayed Neurotoxicity in Relapsed/Refractory Multiple Myeloma: Clinical and Translational Insights

Rapid and excessive expansion of ciltacabtagene autoleucel (cilta-cel) CAR T-cells associates with delayed neurotoxicity in relapsed/refractory multiple myeloma, with absolute lymphocyte count serving as a practical biomarker to guide early

Oct 29, 2026
Clinical Updates

Differential Trajectories of Brain Atrophy in Multiple Sclerosis, MOGAD, and AQP4+ NMOSD: Unraveling the Impact of Disease Activity in MOGAD

This review synthesizes evidence comparing brain atrophy patterns in MS, MOGAD, and AQP4+ NMOSD, highlighting MOGAD’s atrophy association with inflammatory activity and lesion dynamics, emphasizing distinct pathogenic mechanisms and c

Oct 28, 2026
Clinical Updates

Low-Carbohydrate Diets, Nutritional Adequacy, Glycemia, and Perinatal Outcomes in Women With Gestational Diabetes Mellitus: Insights from the DiGest Trial and Contemporary Evidence

This review synthesizes current evidence on low-carbohydrate diets in gestational diabetes mellitus (GDM), highlighting effects on glycemia, nutrient adequacy, and perinatal outcomes from the DiGest trial and supporting literature.

Oct 28, 2026
Allergy & Immunology

Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks: A Phase 3, Multicentre, Randomised, Double-Blind, Placebo-Controlled Crossover Trial and Related Evidence

This review synthesizes phase 3 RAPIDe-3 trial results demonstrating oral deucrictibant’s rapid efficacy and safety for hereditary angioedema attacks, contextualized with phase 2 studies and prophylactic applications, highlighting its

Oct 28, 2026
Neurology

Systemic Fluoroquinolones and Peripheral Neuropathy Risk: Comprehensive Evidence Review and Clinical Implications

A thorough review of systemic fluoroquinolone use reveals minimal association with peripheral neuropathy risk compared to cephalosporins, supported by large cohort studies and pharmacovigilance data, guiding safer antibiotic prescribing.

Oct 27, 2026
Clinical Updates

Impact of Substantial Preoperative Weight Loss on Postoperative Outcomes and Healthcare Utilization Following Reduction Mammoplasty in Obese Patients

Recent substantial preoperative weight loss (>10%) in obese patients undergoing reduction mammoplasty is associated with increased surgical site infections and hospital readmissions compared to weight-stable obese patients, highlighting

Oct 27, 2026
Clinical Updates

Venetoclax Plus Azacitidine in Younger Adults with Acute Myeloid Leukemia: Evolving Evidence Beyond Historical Comparisons

Review of recent studies highlights venetoclax plus azacitidine as a feasible and effective therapy in younger AML patients, challenging standard intensive chemotherapy paradigms and suggesting a shift toward lower-intensity regimens with c

Oct 27, 2026
Clinical Updates

Natural History, Treatment, Survival, and Causes of Mortality in Patients With Subsolid and Ground-Glass Nodules: A Comprehensive Clinical Review

This review synthesizes current evidence on subsolid nodules (SSNs) and ground-glass opacities (GGOs), focusing on their natural history, treatment strategies including ablation and surgery, survival outcomes, and mortality causes. It highl

Oct 27, 2026
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  1. 01Cardiology

    Physical Activity Trajectories Before and After Cardiovascular Disease: Insights from the CARDIA Study

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