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A novel machine learning-based model demonstrates improved risk prediction in transthyretin amyloid cardiomyopathy, surpassing traditional staging systems and supporting personalized patient management.
The PROFID study reveals a declining mortality benefit from primary prevention implantable cardioverter-defibrillators in post-myocardial infarction patients with reduced ejection fraction over recent decades, highlighting changing clinical
EUROASPIRE VI exposes wide gaps between ESC prevention and cardiac rehabilitation recommendations and everyday care across Europe — especially in high-risk regions. This article distills core guideline recommendations, what’s new, and
Evolocumab significantly reduces first and subsequent major adverse cardiovascular events in high-risk patients without prior myocardial infarction or stroke, affirming the benefit of intensive LDL-C lowering for cumulative cardiovascular r
Lower ventricular chamber stiffness predicts adverse outcomes in Fontan patients, revealing a high-compliance, eccentric remodeling phenotype distinct from traditional stiffening hypotheses.
Long-term intensive BP control led by trained nonphysician community providers significantly lowers cardiovascular risk over 7 years, with benefits persisting 3 years post-intervention in rural China.
An international multicenter study shows ICDs effectively prevent sudden death in high-risk hypertrophic cardiomyopathy patients, demonstrating low mortality rates and significant lifesaving interventions over long-term follow-up.
Baseline plasma levels of CPVL and PIGR correlate with anthracycline-induced systolic dysfunction, offering potential early biomarkers for cardiotoxicity in hematologic malignancy patients undergoing chemotherapy.
This study reveals distinct sex differences in skeletal muscle inflammation and dysfunction in patients with HFrEF, highlighting divergent immune cell profiles linked to muscle mass and strength variations in men versus women, advancing und
This review synthesizes current evidence on myocardial fibrosis and ventricular remodeling after AVR in chronic AR, highlighting imaging biomarkers, remodeling patterns, and functional outcomes relevant to clinical practice.
This review synthesizes evidence on the prevalence and prognostic value of right ventricular dysfunction in ATTR-CM and the therapeutic impact of vutrisiran on RV function from the HELIOS-B trial, underscoring RV free wall strain as a key b
This article explores the vital role of the vagus nerve in modulating myocardial infarction outcomes through autonomic regulation, reflex pathways, and cardioprotective mechanisms, highlighting translational potential from experimental mode
Echocardiography-derived right ventricular phenotypes improve prognostic accuracy beyond standard risk tools in pulmonary arterial hypertension patients at first follow-up, refining survival predictions and guiding management strategies.
This cluster-randomized trial in rural China demonstrates that a coordinated community- and family-based intervention effectively lowers systolic blood pressure at the population level, highlighting the importance of sustained community eng
Combined intrahepatic and periduodenal lymphatic embolization significantly improves protein balance and remission duration in congenital heart disease patients with protein-losing enteropathy compared to intrahepatic embolization alone, of
This prospective registry reveals a significantly increased risk of stroke or transient ischemic attack within 30 days after pulsed field ablation compared to radiofrequency ablation for atrial fibrillation, highlighting important safety co
This study reveals that pulmonary artery stiffness and right ventricular function parameters independently predict mortality better than pulmonary vascular resistance in mild pulmonary hypertension, supporting their role in early disease ri
A Swedish cohort study reveals increased adoption and high adherence to quadruple pharmacotherapy in HFrEF, associating treatment persistence with better clinical outcomes and highlighting areas for improved dosing and continuation.
This study demonstrates the lack of mechanistic specificity of clinical capillary leak indices in heart failure patients, underscoring their limitations as universal markers of endothelial permeability beyond acute inflammatory states.
Cascade genetic screening in hereditary transthyretin amyloidosis (ATTRv) enables earlier diagnosis and intervention, improving survival and highlighting the need for variant-specific surveillance strategies.
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