Section
A gene-specific, risk-based screening algorithm for relatives with titin-truncating variants optimizes monitoring intervals from 1 to 5 years, improving safety and resource use in dilated cardiomyopathy surveillance.
The SUSTAIN-IT study reveals variable improvements in health-related quality of life over two years following heart transplantation or long-term mechanical circulatory support in older heart failure patients, highlighting important consider
This study identifies plasma proteomic signatures linked to clonal hematopoiesis driver mutations and develops a proteomic risk score that independently predicts adverse clinical outcomes in heart failure with preserved ejection fraction (H
This study evaluates risk factors for intracranial haemorrhage after tenecteplase fibrinolysis in STEMI patients, developing a prediction model highlighting age, blood pressure, sex, weight, and dose interactions as key determinants.
This study reveals that lipid profiles paradoxically worsen during the early remission phase after curative surgery for Cushing’s syndrome, highlighting a critical window for cardiovascular risk and targeted intervention.
A clinician-focused summary of the 2026 ACC Scientific Statement on gene editing for cardiovascular disease, highlighting indications, recommendations, safety monitoring, ethical issues, and practical steps for integrating these therapies i
This article reviews a large institutional study highlighting a low incidence of coronary malperfusion following stentless bioprosthetic aortic root replacement using the Freestyle valve and techniques to reduce this complication.
This meta-analysis of 87 randomized trials finds that increasing whole-grain intake is associated with improved cardiometabolic risk factors including reduced body weight, cholesterol, and blood pressure, particularly at daily intakes of 60
Left ventricular pressure overload induces metabolic vulnerability that heightens susceptibility to anthracycline cardiotoxicity, revealing a critical need for targeted preventive strategies in patients with hypertension or valvular disease
This study reveals that angiotensin II via TGF-β1 upregulates platelet PAR4, promoting hyperactivation and thrombosis in hypertension, with valsartan attenuating this pathway and thrombotic risk.
Low-dose rivaroxaban failed to reduce cardiovascular events but increased major bleeding in advanced CKD patients at high cardiovascular risk, underscoring the need for cautious anticoagulant use.
Breast cancer independently increases atrial fibrillation risk via tumour-secreted ADAM10, which induces atrial fibrosis through the Ephrin B2 signaling pathway, offering a potential new therapeutic target.
Concise review of the 2025 VA/DoD lipid guideline: new risk tool (PREVENT), CAC and one-time Lp(a) for risk refinement, statins for selected primary prevention groups (including people with HIV), and intensified combination therapy for very
This study demonstrates that elevated brain natriuretic peptide (BNP) post-pulmonary endarterectomy strongly predicts mortality in chronic thromboembolic pulmonary hypertension (CTEPH), providing valuable prognostic information beyond persi
Higher hospital cardiac capability correlates with lower mortality in cardiogenic shock patients, and regionalized hub-and-spoke models mitigate the transfer penalty associated with patient instability.
Among older adults receiving CAR-T therapy, 5.8% experienced major adverse cardiovascular events (MACE), associated with increased mortality. Pre-existing cardiac conditions heightened risk, underscoring the need for cardiovascular monitori
This study identifies novel proteomic and metabolomic biomarkers linked to cardiac dysfunction and remodeling in breast cancer patients treated with cardiotoxic therapies, revealing potential pathways for early detection and intervention.
This updated meta-analysis of 28 RCTs reveals significant reductions in cardiovascular events and mortality with intracoronary imaging-guided PCI versus angiography-guided PCI, highlighting the importance of lesion and geographic factors in
This article reviews novel research showing how cytoplasmic mislocalization of RBM20 impairs mitochondrial function, leading to severe dilated cardiomyopathy and highlighting distinct mechanisms between gain- and loss-of-function RBM20 vari
This article discusses the role of cyclin D1 (CCND1) in promoting reparative macrophage transition post-myocardial infarction, highlighting its therapeutic potential in reducing adverse cardiac remodeling through metabolic reprogramming.
