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The SUSTAIN-IT study evaluated changes in health-related quality of life (HRQOL) over two years in older adults (60-80 years) with advanced heart failure undergoing heart transplantation (HT) or long-term mechanical circulatory support (MCS). Patients who underwent HT without pretransplant MCS and those with long-term MCS experienced significant and sustained improvements in HRQOL, whereas those with HT and pretransplant MCS showed limited HRQOL gains. Long-term MCS was associated with lower overall HRQOL scores compared to HT without MCS.
