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This meta-analysis reveals significant geographic differences in the benefits of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI), with East Asian populations showing marked reductions in cardiac death and adv
A deep-intronic MYBPC3 variant magnifies natural mRNA missplicing events, causing hypertrophic cardiomyopathy and explaining previously genotype-negative cases through an ancient founder effect and novel splice regulation.
This study examines how cardiac MRI postprocessing methods, including trabeculation exclusion and pulmonary artery flow measurement sites, significantly influence right ventricular volume and function assessment in pulmonary hypertension pa
This study compares long-term outcomes of endovascular versus open bypass interventions for femoropopliteal disease in patients with claudication, finding similar rates of major adverse limb events and progression to critical limb ischemia
This comparative analysis assesses ischemic stroke outcomes in patients with asymptomatic carotid stenosis undergoing transcarotid artery revascularization (TCAR) versus carotid artery stenting (CAS), highlighting no significant difference
The MYSTICS Registry provides robust data on cardiac sarcoidosis, highlighting diagnostic challenges, treatment patterns, and prognostic differences among phenotypes, emphasizing tailored management strategies to improve patient outcomes.
The TARGET-D trial investigated whether vitamin D supplementation, titrated to achieve serum levels >40-80 ng/mL, reduces major adverse cardiovascular events after myocardial infarction but found no significant benefit in the primary com
This article explores the integration of evidence-based medicine and personalized approaches in managing heart failure and inherited cardiomyopathies, proposing a framework to optimize patient care by harmonizing standardized guidelines wit
This randomized trial evaluates the safety and efficiency of the ESC 0/1-hour versus 0/3-hour high-sensitivity troponin pathways in suspected acute coronary syndrome, showing noninferior safety but no significant improvement in rapid discha
The BRIGHT-4 trial demonstrates that bivalirudin with prolonged infusion reduces 30-day mortality and major bleeding compared to heparin in STEMI patients undergoing radial primary PCI, benefiting both low and higher bleeding risk groups.
This study explores cardiac structural and functional changes over prolonged spaceflight and simulated Martian gravity, revealing transient adaptations that stabilize without lasting detrimental effects, suggesting effective cardiovascular
Recent research identifies intestinal serotonin 5-HT3a receptor signaling via vagal neurons as a key mediator of microbiota-induced hypertension, offering new insights into resistant hypertension and potential therapeutic targets.
The CREST-2 trial substantiates carotid artery stenting plus intensive medical management significantly reduces stroke risk in high-grade asymptomatic carotid stenosis compared to medical therapy alone, emphasizing patient selection and pro
Study found that use of an AI-driven gamified mobile app integrating home blood pressure monitoring significantly improved blood pressure control compared to usual care in hypertensive patients.
Digitalis glycosides reduce cardiovascular death or worsening heart failure events in HFmrEF and HFrEF patients over a median of 36–37 months, supported by randomized trials and meta-analyses highlighting their role in select heart failure
Pharmacological activation of CXCR7 regulates platelet lipid metabolism, preserves mitochondrial function, and reduces procoagulant activity, offering a novel therapeutic strategy to mitigate thrombotic risk in cardiovascular diseases.
An analysis of elective endovascular repair outcomes in nonagenarians shows similar 30-day mortality to younger patients, supporting individualized treatment decisions based on risk rather than age alone.
This study reveals how cardiac resynchronization therapy (CRT) improves left ventricular function in heart failure patients and modulates systemic metabolomic profiles, highlighting differences between ischemic and nonischemic cardiomyopath
This study reveals genotype-specific differences in atrial fibrillation (AF) risk among dilated cardiomyopathy (DCM) patients, highlighting LMNA mutations as a major predictor of incident AF and its association with worse clinical outcomes,
Subclinical liver disease, marked by steatosis, fibrosis, and functional impairment, independently and synergistically increases cardiovascular disease risk. Incorporating non-invasive liver biomarkers could enhance CVD risk prediction and
