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Validating the Venous Excess Ultrasound Score (VExUS) for Right Atrial Pressure Assessment in Pulmonary Hypertension: A Multicenter Study
CardiologyHuyết Áp PhổiRight Heart Catheterization

Validating the Venous Excess Ultrasound Score (VExUS) for Right Atrial Pressure Assessment in Pulmonary Hypertension: A Multicenter Study

By MedXY|Sep 3, 2026

This multicenter study validates the Venous Excess Ultrasound Score (VExUS) as a highly accurate, noninvasive tool to predict right atrial pressure in patients evaluated for pulmonary hypertension, outperforming isolated echocardiographic m

Finerenone in Hypertensive Non-Diabetic Chronic Kidney Disease: Evidence from the FIND-CKD Subgroup Analysis
CardiologyfinerenoneHypertensive Nephropathy

Finerenone in Hypertensive Non-Diabetic Chronic Kidney Disease: Evidence from the FIND-CKD Subgroup Analysis

By MedXY|Sep 3, 2026

Finerenone significantly slows kidney function decline and reduces cardiovascular risk in hypertensive non-diabetic CKD patients, with manageable safety profiles, supporting its therapeutic role beyond diabetes.

Rising Cardiovascular Disease Burden at Cancer Diagnosis: Insights from a National English Cohort and Future Projections
Cardiologycardiovascular diseasecomorbidity trends

Rising Cardiovascular Disease Burden at Cancer Diagnosis: Insights from a National English Cohort and Future Projections

By MedXY|Sep 3, 2026

This national English study reveals a significant increase in pre-existing cardiovascular disease among patients at cancer diagnosis over two decades, projecting nearly half will have cardiovascular comorbidities by 2050, underlining urgent

Consistent Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis Amidst Concomitant Disease-Modifying Therapies
CardiologyDisease-Modifying TherapyHELIOS-B trial

Consistent Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis Amidst Concomitant Disease-Modifying Therapies

By MedXY|Sep 3, 2026

The HELIOS-B trial demonstrates that vutrisiran significantly reduces mortality and cardiovascular events in ATTR-CM patients, with its efficacy unaffected by concurrent use of tafamidis or heart failure medications, supporting its broad th

Transcatheter Aortic Valve Replacement in Paradoxical Low-Flow, Low-Gradient Aortic Stenosis: Insights from the REBOOT-PARADOX Trial
CardiologyREBOOT-PARADOXOptimal Medical Therapy

Transcatheter Aortic Valve Replacement in Paradoxical Low-Flow, Low-Gradient Aortic Stenosis: Insights from the REBOOT-PARADOX Trial

By MedXY|Sep 3, 2026

The REBOOT-PARADOX trial evaluated TAVR plus medical therapy versus medical treatment alone in symptomatic paradoxical low-flow, low-gradient aortic stenosis, showing no definitive mortality benefit but supporting personalized care with tim

Aficamten’s Impact on Cardiac Function and Structure in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Insights from ACACIA-HCM Trial
CardiologyechocardiographyNonobstructive Hypertrophic Cardiomyopathy

Aficamten’s Impact on Cardiac Function and Structure in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Insights from ACACIA-HCM Trial

By MedXY|Sep 3, 2026

Aficamten significantly improves diastolic function and cardiac structure in symptomatic nonobstructive hypertrophic cardiomyopathy, indicating benefits beyond outflow tract gradient reduction.

Oral Relaxin Receptor Agonist AZD5462 Shows Promise in Chronic Heart Failure: Insights from the LUMINARA Trial
Cardiologysystemic vascular resistanceAZD5462

Oral Relaxin Receptor Agonist AZD5462 Shows Promise in Chronic Heart Failure: Insights from the LUMINARA Trial

By MedXY|Sep 3, 2026

The LUMINARA trial evaluates AZD5462, an oral relaxin receptor agonist, demonstrating safety and promising effects on cardiac remodeling and vascular resistance in chronic heart failure, warranting further large-scale investigation.

Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness: A Comprehensive Review
CardiologyGLP-1 receptor agonistsserious mental illness

Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness: A Comprehensive Review

By MedXY|Sep 2, 2026

GLP-1 receptor agonists reduce mortality and cardiovascular events more effectively than SGLT2 inhibitors in serious mental illness (SMI), with early benefits and consistent effects across bipolar disorder, major depression, and schizophren

Specialist Cardiovascular Referral Enhances Cholesterol Management in Prostate Cancer Patients: Insights from a Global Randomized Trial
Cardiologyprostate cancercardiovascular risk

Specialist Cardiovascular Referral Enhances Cholesterol Management in Prostate Cancer Patients: Insights from a Global Randomized Trial

By MedXY|Sep 1, 2026

A randomized clinical trial demonstrates that routine cardiovascular specialist referral for prostate cancer patients improves cholesterol control but does not reduce major cardiovascular events over nearly 6 years.

Direct Lymphangiography-Guided Cervical Thoracic Duct Exploration: Advancing Management of Primary Chylopericardium through Reflux Pattern Stratification and Long-Term Outcomes
Cardiologydirect lymphangiographyprimary chylopericardium

Direct Lymphangiography-Guided Cervical Thoracic Duct Exploration: Advancing Management of Primary Chylopericardium through Reflux Pattern Stratification and Long-Term Outcomes

By MedXY|Sep 6, 2026

This study characterizes abnormal lymphatic reflux patterns in primary chylopericardium using direct lymphangiography and demonstrates that guided cervical thoracic duct exploration yields a 66% long-term success rate, with specific reflux

Refining Myocardial Infarction Diagnosis: A Novel Causal Endotype-Based Classification Beyond Type 1 and Type 2 MI
Cardiologycausal endotypesmyocardial infarction

Refining Myocardial Infarction Diagnosis: A Novel Causal Endotype-Based Classification Beyond Type 1 and Type 2 MI

By MedXY|Sep 1, 2026

This study introduces a causal endotype-based classification of myocardial infarction, revealing distinct underlying mechanisms and clinical outcomes beyond the traditional type 1/type 2 framework, potentially improving MI diagnosis and man

Optimizing Antithrombotic Therapy After PCI in Atrial Fibrillation Patients: Insights from a Network Meta-Analysis
CardiologyLiệu pháp chống huyết khốiDirect Oral Anticoagulants

Optimizing Antithrombotic Therapy After PCI in Atrial Fibrillation Patients: Insights from a Network Meta-Analysis

By MedXY|Sep 1, 2026

This article explores the latest evidence on antithrombotic therapy after PCI in patients with atrial fibrillation, highlighting the balance between bleeding risk and prevention of ischemic events.

Cardiovascular Prevention Among Healthcare Professionals: Insights from the ESC Congress Cardiovascular Health Check 2025
Cardiologyguideline adherencecardiovascular prevention

Cardiovascular Prevention Among Healthcare Professionals: Insights from the ESC Congress Cardiovascular Health Check 2025

By MedXY|Sep 1, 2026

Healthcare professionals face significant gaps in cardiovascular prevention despite their critical role in care. The ESC Congress 2025 revealed prevalent modifiable risks, underuse of therapies, and subclinical atherosclerosis, underscoring

Vutrisiran and Tafamidis in Transthyretin Amyloidosis Cardiomyopathy: Evaluating Combination Therapy Insights from HELIOS-B
CardiologyATTR-CMRNA 干扰

Vutrisiran and Tafamidis in Transthyretin Amyloidosis Cardiomyopathy: Evaluating Combination Therapy Insights from HELIOS-B

By MedXY|Sep 1, 2026

The HELIOS-B trial showed vutrisiran improves survival and cardiac outcomes in transthyretin amyloidosis with cardiomyopathy, with consistent benefits regardless of baseline tafamidis use, supporting further evaluation of combination therap

Short-Term Anticoagulant Therapy and Subclinical Leaflet Thickening in Transcatheter Aortic Valves: Evidence and Insights from the NOTION-4 Trial
CardiologyTAVRDOAC

Short-Term Anticoagulant Therapy and Subclinical Leaflet Thickening in Transcatheter Aortic Valves: Evidence and Insights from the NOTION-4 Trial

By MedXY|Sep 1, 2026

The NOTION-4 trial demonstrates that 3 months of DOAC therapy post-TAVR reduces early HALT incidence compared to SAPT, but benefits diminish after discontinuation, highlighting nuanced balance between thrombosis prevention and bleeding risk

Improving Heart Failure Outcomes in India: Evidence from the TIME-HF Nurse-Coordinated, Digital-Supported Care Model Trial
Cardiologyheart failuredigital health

Improving Heart Failure Outcomes in India: Evidence from the TIME-HF Nurse-Coordinated, Digital-Supported Care Model Trial

By MedXY|Sep 1, 2026

A nurse-led, mobile health-supported collaborative care intervention significantly increased days alive and out of hospital and reduced mortality among Indian patients with heart failure with reduced ejection fraction over 2 years.

Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Risk Across the Adult Lifespan: Insights from a Large Population Study
CardiologyLipoprotein(a)cardiovascular risk

Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Risk Across the Adult Lifespan: Insights from a Large Population Study

By MedXY|Sep 1, 2026

Elevated lipoprotein(a) confers a consistent relative risk increase for atherosclerotic cardiovascular disease across all adult ages, with absolute risks rising substantially in older adults.

Optimal Early Outcomes in Acute Type A Aortic Dissection Repair: Prioritizing Adequate Perfusion Over Cannulation Strategy
Cardiologyacute type A aortic dissectionearly outcomes

Optimal Early Outcomes in Acute Type A Aortic Dissection Repair: Prioritizing Adequate Perfusion Over Cannulation Strategy

By MedXY|Aug 31, 2026

This study shows that the choice of cannulation site—femoral versus axillary—does not independently affect early mortality or neurological complications after acute type A aortic dissection repair; instead, timely systemic reperfusion and c

RNF213 p.R4810K Variant: A Novel Independent Genetic Risk Factor for Extracranial Carotid Artery Disease
CardiologyExtracranial Carotid Artery DiseaseIntracranial Atherosclerotic Disease

RNF213 p.R4810K Variant: A Novel Independent Genetic Risk Factor for Extracranial Carotid Artery Disease

By MedXY|Aug 29, 2026

The RNF213 p.R4810K variant independently increases risk and severity of extracranial carotid artery disease, distinct from its known association with intracranial atherosclerosis, highlighting new insights into vascular disease genetics an

Revolutionizing Aortic Stenosis Screening: AI-Enabled Focused Cardiac Ultrasound with Novice Operators
AIaortic stenosisartificial intelligence

Revolutionizing Aortic Stenosis Screening: AI-Enabled Focused Cardiac Ultrasound with Novice Operators

By MedXY|Aug 29, 2026

A novel deep learning algorithm accurately detects moderate or greater aortic stenosis using AI-guided focused cardiac ultrasound acquired by novice operators, presenting a scalable solution to expand screening accessibility.

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