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A landmark randomized trial demonstrates that atorvastatin reduces major cardiovascular events in adults aged 70 and older without established cardiovascular disease but does not extend disability-free survival, highlighting nuanced conside
This study reveals that prior hemithyroidectomy increases the risk of gestational hypothyroidism and later gestation complications, including preterm birth or pregnancy loss, underscoring the need for vigilant thyroid monitoring during preg
Elevated baseline CRP levels in older acute HF patients identify those who gain the most physical function improvement from a 12-week rehabilitation program, supporting biomarker-guided therapy.
This study validates a new Contemporary Extended Activities of Daily Living scale, showing it reliably measures functional independence by including modern tasks alongside traditional ones in adults over 60 with chronic conditions.
This multicenter study evaluates the 2-year clinical success, survival, and patient-reported outcomes of 3D-printed complete dentures, demonstrating high durability and stable oral quality of life in edentulous patients.
This review synthesizes phase 3 RAPIDe-3 trial results demonstrating oral deucrictibant’s rapid efficacy and safety for hereditary angioedema attacks, contextualized with phase 2 studies and prophylactic applications, highlighting its
A pediatric IBD patient’s medication denial due to lack of pediatric FDA labeling prompted physician-led advocacy, resulting in a state law mandating insurance coverage for pediatric medications with adult approval and supporting data
This prospective nationwide study identifies baseline peripheral blood UBA1 variant allele frequency as a robust predictor of poor outcomes in VEXAS syndrome, providing a new tool for risk stratification and management.
A new OPTN policy removing race from eGFR calculations shows promise in increasing kidney transplantation access for Black patients by adding waiting time credits, while not disadvantaging others on the waitlist.
In a phase 2 trial, oral QY201 significantly improved skin outcomes in moderate-to-severe atopic dermatitis with favorable safety, supporting further phase 3 evaluation.
Partial cellular reprogramming harnesses Yamanaka factors to rejuvenate aging cells without losing identity, offering transformative potential in plastic surgery and regenerative medicine.
This qualitative study explores practicing physicians’ experiences with humanistic practice, revealing how relationships and resilience foster compassion despite systemic challenges like efficiency demands and standardized care models.
IL-6 receptor inhibition during hematopoietic stem cell transplantation fosters type I interferon responses and promotes expansion of cytolytic CD4+ T cells, including Eomes+ subsets, augmenting antitumor immunity while mitigating graft-ver
The ISOREA survey highlights significant geo-economic disparities in ICU resources and organization worldwide, revealing critical gaps in critical care capabilities particularly in low-income settings, with implications for global health eq
This study compares retinopathy of prematurity severity in US and Indian infants using an AI-derived vascular severity score, revealing epidemiological and pathophysiological differences that could impact diagnosis and management globally.
Early intervention for head and neck cancer-related lymphedema significantly improves swallowing function and patient-reported outcomes, supporting timely multidisciplinary care.
Neoadjuvant therapy alters key prognostic factors in resected pancreatic ductal adenocarcinoma, enabling personalized survival prediction models distinct from chemo-naïve patients.
This prospective Scottish study compares cytology and high-risk HPV testing performance in young HPV-vaccinated women, revealing high negative predictive value but lower positive predictive value of hrHPV testing, emphasizing the role of cy
A thorough review of systemic fluoroquinolone use reveals minimal association with peripheral neuropathy risk compared to cephalosporins, supported by large cohort studies and pharmacovigilance data, guiding safer antibiotic prescribing.
The DASH4D diet, a diabetes-adapted version of the DASH eating plan, significantly improves blood pressure and blood sugar control in type 2 diabetes with hypertension, offering a strong evidence-based dietary recommendation for personalize
