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This study identifies novel proteomic and metabolomic biomarkers linked to cardiac dysfunction and remodeling in breast cancer patients treated with cardiotoxic therapies, revealing potential pathways for early detection and intervention.
This updated meta-analysis of 28 RCTs reveals significant reductions in cardiovascular events and mortality with intracoronary imaging-guided PCI versus angiography-guided PCI, highlighting the importance of lesion and geographic factors in
This article reviews novel research showing how cytoplasmic mislocalization of RBM20 impairs mitochondrial function, leading to severe dilated cardiomyopathy and highlighting distinct mechanisms between gain- and loss-of-function RBM20 vari
This article discusses the role of cyclin D1 (CCND1) in promoting reparative macrophage transition post-myocardial infarction, highlighting its therapeutic potential in reducing adverse cardiac remodeling through metabolic reprogramming.
This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.
A national study examining the shift from hourly to RVU-based pay for emergency physicians found no significant changes in productivity, billing intensity, or key operational metrics, suggesting compensation models may not strongly influenc
This study explores factors that promote or hinder hospitalized patients’ use of Smart Bedside Station systems, revealing that nursing support and useful video education encourage use, while cognitive and workflow challenges limit sus
This review synthesizes evidence identifying critical programmatic factors, relational dynamics, and interventions enhancing hospice transitions in cancer palliative care, emphasizing collaborative oncology-palliative care relationships and
KDIGO 2026 updates anemia care in CKD: evidence-based thresholds for iron therapy, preference for IV iron on hemodialysis, ESA-first approach over HIF-PHIs, individualized Hb initiation, and an ESA maintenance upper Hb target <11.5 g/dL.
A retrospective study demonstrates the safety and efficacy of GCSF and plerixafor for CD34+ stem cell mobilization as autologous backup in sickle cell patients undergoing alternate donor HSCT, with insights relevant for gene therapy.
This phase II study evaluates the all-oral ixazomib-pomalidomide-dexamethasone regimen in triple-class exposed relapsed/refractory multiple myeloma patients, demonstrating promising efficacy and manageable safety in an elderly and high-risk
Long-term phase 1 data confirm asciminib’s efficacy and safety in treating CML-CP patients harboring the resistant BCR::ABL1 T315I mutation, with sustained major molecular responses and manageable adverse events over nearly six years.
This article explores how type-I interferon activates NK cells to control polycythemia vera progression, revealing insights into immune modulation and therapeutic potential in myeloproliferative neoplasms.
This article reviews exploratory analyses from a phase 2b trial examining eosinophil count changes in adults with uncontrolled moderate-to-severe asthma treated with the IL-4Rα inhibitor rademikibart, indicating a low risk of treatment-emer
Distinct Pseudomonas aeruginosa abundance and interaction patterns in bronchiectasis patients reveal heterogeneity influencing clinical outcomes and treatment responses, offering new avenues for personalized management.
This prospective study demonstrates that WaveLight Plus InnovEyes ray-tracing-guided LASIK achieves excellent safety, efficacy, and astigmatic correction precision in treating myopia and myopic astigmatism over one year.
A retrospective cohort study at a safety-net hospital found that routine pathological examination of tonsillectomy specimens rarely reveals unexpected malignancies, supporting targeted pathology based on clinical assessment.
From 2017 to 2023, colonoscopy use increased notably in adults under 50. Yet, early-onset colorectal cancer rates and racial disparities, particularly among Black and Hispanic populations, worsened, highlighting that screening alone does no
The Integrative Muscle-Adipose Score (IMAS) combines muscle and fat measures into a sex-specific tool that accurately predicts long-term survival and postoperative complications in liver transplant recipients, outperforming existing models.
Kynurenic acid (KYNA) reduction in the gut correlates with worse poststroke outcomes. Supplementation activates a gut-brain neural circuit via GPR35 and the vagus nerve, promoting neuroprotection and functional recovery after ischemic strok
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