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This 1-year randomized controlled trial compares the clinical performance, wear, and fracture incidence of 3D-printed resin crowns and zirconia crowns in posterior tooth restorations, revealing acceptable adaptation but higher wear and frac
The EQUAL ACP trial compared facilitated and self-guided advance care planning in Black and White older adults with serious illnesses, revealing no significant difference in overall ACP completion but greater facilitated approach efficacy a
This article explores recent meta-analytic evidence on how device-measured physical activity and sedentary behavior relate to cardiometabolic risk markers in children and adolescents, revealing nuanced benefits of moderate-to-vigorous exerc
The 2026 EULAR update modernizes how recommendations and points-to-consider for rheumatic and musculoskeletal diseases are developed — formalizing patient partnership, living guidance, robust evidence synthesis, cost-awareness and transpare
This Swiss retrospective study reveals that while obesity in kidney transplant recipients increases early surgical complications and delayed graft function, it does not affect long-term patient or graft survival, suggesting obesity alone sh
The Cutaneous Lymphoma International Prognostic Index (CLIPI) enhances risk stratification and predicts progression and treatment response beyond conventional staging in advanced mycosis fungoides and Sézary syndrome.
This study demonstrates that standardized dosing of tranexamic acid, combined with local anesthetic in rhytidectomy, does not increase ischemic or systemic complications, supporting its safe use in facelift procedures.
A German randomized controlled trial demonstrates that Modified Psychodynamic Psychotherapy for Schizophrenia (MPP-S) combined with standard care significantly improves psychosocial functioning over two to three years compared to standard c
This review synthesizes evidence on the derivation and validation of a claims-based algorithm for identifying cardiogenic shock (CS), demonstrating its high diagnostic performance and enabling robust large-scale epidemiologic and long-term
Paramedic-suspected STEMI identified a heterogeneous, high-acuity population where 60% had confirmed STEMI; outcomes vary by final diagnosis, underscoring the need for rapid reperfusion with early diagnostic refinement.
This review synthesizes evidence on women Veterans’ emergency care utilization, comparing VA and Community ED use. It highlights demographic and clinical predictors influencing care settings and underscores the need for tailored coord
KT-253, a selective MDM2 protein degrader, shows potent elimination of malignant myelofibrosis stem/progenitor cells by enhancing p53 pathway activation, outperforming current MDM2 inhibitors and offering a promising therapeutic advance.
Ondansetron, a 5-HT3 antagonist, reduces respiratory drive in ARDS patients on mechanical ventilation by attenuating pulmonary C-fiber mediated stimulation, potentially lessening lung injury and improving oxygenation.
CDK4/6 inhibitor therapy in hormone receptor-positive breast cancer is linked to increased corneal epithelial alterations, including punctate epitheliopathy and vortex keratopathy, independent of aromatase inhibitor effects or tear film dys
This study demonstrates promising accuracy of a patient-personalized AI system in detecting tracheostomy tube status and infant distress via video monitoring, highlighting potential for enhanced, continuous surveillance in high-risk infants
A secondary analysis of the RACC trial reveals robot-assisted radical hysterectomy reduces intraoperative complications but shows similar postoperative morbidity and modest quality-of-life benefits compared with open surgery in early-stage
Two cases of retrograde migration of foreign bodies in the female genital tract were successfully managed with a minimally invasive hysteroscopic technique involving electrosurgical radial incision and Foley catheter dilation, emphasizing s
MTFP1 promotes pancreatic ductal adenocarcinoma liver metastasis by enhancing mitochondrial oxidative phosphorylation via the ROS/PI3K/AKT/c-MYC/SLC1A5 axis, revealing a promising therapeutic target to reverse tumor immune suppression and r
This study investigates how patients’ perceived social standing influences stroke recovery at 3 and 12 months, highlighting the role of psychological distress and identifying subjective social status as a key social determinant of long-term
This study clarifies that the metabolic risks linked to fat-free mass are largely dependent on visceral and muscle fat infiltration, not FFM alone, highlighting the need for nuanced assessment in metabolic syndrome risk.
