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SLA-DR–Deleted Donor Pigs Show Durable Kidney Xenograft Function and a Favorable Safety Profile in Rhesus Monkeys
General Surgerykidney transplantrhesus monkey

SLA-DR–Deleted Donor Pigs Show Durable Kidney Xenograft Function and a Favorable Safety Profile in Rhesus Monkeys

By MedXY|Jun 6, 2026

CRISPR-engineered GGTA1/B4GALNT2/SLA-DR knockout pigs remained healthy, screened negative for 55 zoonotic pathogens, and supported long-term renal xenograft function in rhesus monkeys when preformed anti-SLA antibodies were absent.

Sự viêm vi mạch bẩm sinh sớm và kích hoạt nội mô xác định đặc điểm miễn dịch chủng khác sau ghép tim lợn sang người
newsdiagnosticsimmune response

Sự viêm vi mạch bẩm sinh sớm và kích hoạt nội mô xác định đặc điểm miễn dịch chủng khác sau ghép tim lợn sang người

By MedXY|Dec 3, 2025

Phân tích đa chế độ của hai quả tim lợn đã được chỉnh sửa gen 10 gen được ghép vào người đã chết não cho thấy sự viêm vi mạch bẩm sinh sớm với kích hoạt nội mô và hồ sơ phân tử phù hợp với tổn thương do kháng thể mặc dù không có C4d trong m

Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation
Cardiologydiagnosticsimmune response

Early Innate Microvascular Inflammation and Endothelial Activation Define the Xenoimmune Signature After Pig-to-Human Heart Transplantation

By MedXY|Dec 2, 2025

Multimodal analysis of two 10-gene–edited pig hearts transplanted into brain-dead human recipients revealed early innate microvascular inflammation with endothelial activation and a molecular profile consistent with antibody-mediated injury

IXA Position Paper: Practical Roadmap for First-in-Human Porcine Kidney Xenotransplantation
Nephrologykidney transplantxenotransplantation

IXA Position Paper: Practical Roadmap for First-in-Human Porcine Kidney Xenotransplantation

By MedXY|Oct 28, 2025

The International Xenotransplantation Association (IXA) 2025 position paper offers evidence-based recommendations for initial clinical trials of genetically engineered porcine kidney transplants for end-stage renal disease, focusing on dono

Breaking New Ground: The First Genetically Engineered Pig-to-Human Liver Xenotransplantation
Gastroenterologyliver transplantationthrombotic microangiopathy

Breaking New Ground: The First Genetically Engineered Pig-to-Human Liver Xenotransplantation

By MedXY|Oct 27, 2025

This landmark study reports the first successful genetically engineered pig auxiliary liver transplanted into a living human, revealing critical insights on immunological compatibility and post-transplant complications, advancing liver xeno

Xenotransplantation: Bridging the Gap in Liver Transplantation with Genetically Modified Pig Organs
Gastroenterologyxenotransplantation

Xenotransplantation: Bridging the Gap in Liver Transplantation with Genetically Modified Pig Organs

By MedXY|Oct 22, 2025

Recent advances in genetically modified pig-to-human organ transplantation offer promising solutions for acute liver failure, bridging critical gaps in organ availability and raising important ethical and regulatory considerations.

Combined Liver–Kidney Transplantation: Four Decades of Transformative Impact and Future Horizons
Clinical Updatesimmunosuppressionsurgical innovation

Combined Liver–Kidney Transplantation: Four Decades of Transformative Impact and Future Horizons

By MedXY|Oct 9, 2025

Since the landmark combined liver–kidney transplant in 1984, advances in surgical techniques, immunosuppression, and donor allocation have revolutionized care for patients with dual organ failure. Emerging innovations, including gene-edited

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