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This study examines differences in effect estimates between cluster-randomized and individually randomized clinical trials in prehospital, emergency, and critical care, revealing systematic bias in length-of-stay outcomes but not mortality.
A significant brachial-to-radial arterial pressure gradient occurs in nearly one-fifth of critically ill patients receiving vasoactive agents, correlating with higher vasoactive doses, greater illness severity, and increased ICU mortality.
The ISOREA survey highlights significant geo-economic disparities in ICU resources and organization worldwide, revealing critical gaps in critical care capabilities particularly in low-income settings, with implications for global health eq
A prospective study reveals that caregivers of ICU sepsis survivors frequently suffer long-lasting mental health issues strongly linked to patients’ mental impairments, underscoring the need for targeted mental health support.
This review synthesizes evidence linking tele-critical care with interhospital transfer patterns and outcomes, highlighting improved transfer selection and reduced low-value transfers among critically ill Medicare patients.
This study develops and evaluates prognostic models combining clinical and toxicity information to predict complicated outcomes in ICU patients with acute intoxication, demonstrating the added value of laboratory data over toxicity scores a
A randomized clinical trial compared three high-flow nasal cannula weaning protocols in critically ill adults, finding no significant differences in success rates or weaning duration across flow reduction, FiO2 reduction, and simultaneous r
A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.
This RCT demonstrates that combining multidimensional functional training with inspiratory muscle training and chest physiotherapy improves weaning success, muscle strength, functional independence, pain reduction, and ICU stay following em
A 34-day-old male infant with serum sodium >200 mmol/L from accidental salt ingestion was successfully treated with peritoneal dialysis, leading to full recovery.
A large randomized trial finds no difference in 90-day days alive and out of hospital between early vasopressors with restricted fluids versus higher fluids with delayed vasopressors in septic shock, though pulmonary edema was less frequent
A decade-long analysis reveals a modest decline and delayed timing in withdrawal of life-sustaining treatment among patients with traumatic brain injury, highlighting evolving prognostic attitudes and clinical decision-making.
This nationwide study reveals that hospitals with higher tendencies for early tracheostomy in severe TBI patients also show increased rates of withdrawal of life-sustaining treatment, highlighting significant practice variability and its po
A Swiss study reveals ICU professionals’ perceptions, knowledge, and ethical views on brain death, highlighting knowledge gaps and the positive impact of clinical experience on understanding.
Colonic fistulas in necrotizing pancreatitis do not always require surgery. Low-risk patients with lower BISAP scores may be successfully managed nonoperatively, reducing ICU stays and hospital length without compromising survival.
ChatGPT-4o achieves high accuracy on critical care board questions but shows notable limitations in image interpretation and reasoning, posing potential clinical risks.
Integrating transesophageal lung ultrasound with resuscitative transesophageal echocardiography in mechanically ventilated shock patients improves operator-reported shock etiology identification with minimal added procedure time, suggesting
This study analyzes the epidemiology, treatment processes, and outcomes of critically ill cirrhosis patients undergoing continuous renal replacement therapy, highlighting high mortality rates, anticoagulation practices, and implications of
This study identifies three distinct phenotypes among patients failing to wean from invasive mechanical ventilation, linking failed initial attempts, withdrawal decisions, and mortality, highlighting the need for tailored management strateg
This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.
