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Evaluating Cusatuzumab Combined with Venetoclax ± Azacitidine in Unfit Newly Diagnosed AML: Insights from the Phase Ib ELEVATE Trial
Hematology-Oncologyacute myeloid leukemiaazacitidine

Evaluating Cusatuzumab Combined with Venetoclax ± Azacitidine in Unfit Newly Diagnosed AML: Insights from the Phase Ib ELEVATE Trial

By MedXY|Sep 9, 2026

The phase Ib ELEVATE study demonstrates that cusatuzumab combined with venetoclax and azacitidine offers a promising tolerable and effective frontline therapy for patients with newly diagnosed acute myeloid leukemia ineligible for intensive

Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT
Critical Careintensive careHeatstroke

Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT

By MedXY|Sep 3, 2026

A pilot randomized trial comparing targeted temperature management at 35°C versus normothermia in intubated heatstroke patients showed no survival or neurological benefit from hypothermia but increased gastrointestinal injury and arrhythmia

Gabapentin for Cough in Idiopathic Pulmonary Fibrosis: Efficacy and Safety Insights from a Randomized Controlled Trial
Clinical Updateschronic coughGabapentin

Gabapentin for Cough in Idiopathic Pulmonary Fibrosis: Efficacy and Safety Insights from a Randomized Controlled Trial

By MedXY|Sep 1, 2026

A randomized, double-blind, placebo-controlled trial demonstrates gabapentin’s significant efficacy and acceptable safety for treating cough in IPF, supporting its clinical use amid limited alternatives.

Individualized vs Standard Blood Pressure Control During Mechanical Thrombectomy for Acute Ischemic Stroke: Insights from the DETERMINE Randomized Clinical Trial
Critical Caremechanical thrombectomycase report

Individualized vs Standard Blood Pressure Control During Mechanical Thrombectomy for Acute Ischemic Stroke: Insights from the DETERMINE Randomized Clinical Trial

By MedXY|Aug 24, 2026

A randomized clinical trial comparing individualized versus standard blood pressure control during mechanical thrombectomy for ischemic stroke showed no significant difference in 90-day functional outcomes or safety.

Deupirfenidone: A New Horizon in Slowing Idiopathic Pulmonary Fibrosis Progression
newsIdiopathic Pulmonary FibrosisDeupirfenidone

Deupirfenidone: A New Horizon in Slowing Idiopathic Pulmonary Fibrosis Progression

By MedXY|Aug 17, 2026

Deupirfenidone, a deuterated form of pirfenidone, demonstrated efficacy in slowing lung function decline in IPF patients, with a favorable safety profile in a phase 2b trial, offering promise for improved treatment outcomes.

Balancing Risks: Antiplatelet Therapy After Intracerebral Haemorrhage in the STATICH Trial
Internal Medicinestroke preventionAntiplatelet Therapy

Balancing Risks: Antiplatelet Therapy After Intracerebral Haemorrhage in the STATICH Trial

By MedXY|Aug 18, 2026

The STATICH trial assessed safety and efficacy of antiplatelet therapy after intracerebral hemorrhage, revealing increased hemorrhagic risk but fewer ischemic events among treated patients, highlighting ongoing clinical dilemmas.

Evaluating Androgen Receptor Inhibition Combined with Hormonal Therapies in Recurrent Adult-Type Ovarian Granulosa Cell Tumor: Insights from a Phase II Study
newsdarolutamideandrogen receptor inhibition

Evaluating Androgen Receptor Inhibition Combined with Hormonal Therapies in Recurrent Adult-Type Ovarian Granulosa Cell Tumor: Insights from a Phase II Study

By MedXY|Aug 18, 2026

A Phase II trial assessed the combination of darolutamide, leuprolide acetate, and exemestane in recurrent adult-type ovarian granulosa cell tumor, showing limited objective response but clinically meaningful progression-free survival witho

Pembrolizumab Combined with Radiotherapy Shows Promise in Advanced Cutaneous T-Cell Lymphoma: Final Results from UK NCRI Phase II Trial
Hematology-OncologyCutaneous T-Cell LymphomaRadiotherapy

Pembrolizumab Combined with Radiotherapy Shows Promise in Advanced Cutaneous T-Cell Lymphoma: Final Results from UK NCRI Phase II Trial

By MedXY|Aug 10, 2026

The UK NCRI phase II trial demonstrates pembrolizumab with localized radiotherapy yields meaningful response rates and durable control in relapsed/refractory advanced cutaneous T-cell lymphoma, marking an important step in improving outcome

Tavapadon in Early Parkinson’s Disease: Promising Phase 3 Trial Highlights Safety and Motor Symptom Benefits
NeurologyD1/D5 agonistMotor symptoms

Tavapadon in Early Parkinson’s Disease: Promising Phase 3 Trial Highlights Safety and Motor Symptom Benefits

By MedXY|Aug 9, 2026

The phase 3 TEMPO-2 trial demonstrates that flexible-dose tavapadon, a selective D1/D5 dopamine receptor agonist, significantly improves motor symptoms in early Parkinson’s disease with a manageable safety profile, warranting further

Structured Telehealth Community Health Worker-Clinician Feedback and Diabetes Outcomes: A Randomized Clinical Trial
Diabetes & Endocrinologytelehealthdiabetes

Structured Telehealth Community Health Worker-Clinician Feedback and Diabetes Outcomes: A Randomized Clinical Trial

By MedXY|Aug 5, 2026

This study demonstrates that a telehealth-supported community health worker program with structured feedback loops significantly improves diabetes control and care adherence in low-income Hispanic adults.

Culturally Tailored Meal Program Reduces Hospitalizations in Navajo Patients With Heart Failure: The MUTTON-HF Trial
Cardiologyheart failureThực Phẩm là Thuốc

Culturally Tailored Meal Program Reduces Hospitalizations in Navajo Patients With Heart Failure: The MUTTON-HF Trial

By MedXY|Jul 29, 2026

In a randomized trial among Navajo patients with heart failure, an 8-week culturally tailored meal program reduced all-cause hospitalization or ED visits by 28% compared with usual dietary advice, with improvements in quality of life and food security.

Olorofim for Poorly Controlled Disseminated Coccidioidomycosis: Phase 2b Clinical Efficacy and Safety Insights
Cardiologyantifungal therapyclinical trial

Olorofim for Poorly Controlled Disseminated Coccidioidomycosis: Phase 2b Clinical Efficacy and Safety Insights

By MedXY|Jul 24, 2026

This review synthesizes key findings evaluating olorofim’s clinical effectiveness and safety in patients with refractory disseminated coccidioidomycosis, emphasizing its potential role amid limited treatment options.

LB-102 in Acute Schizophrenia: A Promising Benzamide Antipsychotic with Demonstrated Efficacy and Safety
newsantipsychotic efficacyclinical trial

LB-102 in Acute Schizophrenia: A Promising Benzamide Antipsychotic with Demonstrated Efficacy and Safety

By MedXY|Jul 17, 2026

The phase 2 NOVA1 trial demonstrates that LB-102 significantly improves acute schizophrenia symptoms with a favorable safety profile, supporting its potential as a novel treatment option.

Evaluating Riociguat in Early Pulmonary Vascular Disease: Insights from the ESRA Phase IIa Trial
Cardiologyclinical trialpulmonary arterial hypertension

Evaluating Riociguat in Early Pulmonary Vascular Disease: Insights from the ESRA Phase IIa Trial

By MedXY|Jul 17, 2026

The ESRA trial demonstrates that riociguat is safe and effectively reduces pulmonary vascular resistance in early pulmonary vascular disease, though secondary benefits remain unproven in this early-stage, mostly connective tissue disease-as

Evaluating Consolidative Thoracic Radiotherapy with Atezolizumab Maintenance in Extensive-Stage Small Cell Lung Cancer: Insights from the Phase 2 TREASURE Trial
newsatezolizumabclinical trial

Evaluating Consolidative Thoracic Radiotherapy with Atezolizumab Maintenance in Extensive-Stage Small Cell Lung Cancer: Insights from the Phase 2 TREASURE Trial

By MedXY|Jul 14, 2026

The Phase 2 TREASURE trial investigated the safety and efficacy of adding consolidative thoracic radiotherapy to atezolizumab maintenance in extensive-stage small cell lung cancer, revealing increased toxicity without survival benefit, unde

Evaluating Dose Intensification Strategies for Ustekinumab in Crohn’s Disease: Insights from the REScUE Trial
Gastroenterologyclinical trialCrohn’s disease

Evaluating Dose Intensification Strategies for Ustekinumab in Crohn’s Disease: Insights from the REScUE Trial

By MedXY|Jul 13, 2026

The REScUE study compared two ustekinumab dosing intensification regimens after secondary loss of response in Crohn’s disease, finding no superiority of more frequent dosing regarding steroid-free remission at 48 weeks.

Levacetylleucine Shows Promising Safety and Efficacy in Treating Ataxia-Telangiectasia: Phase 3 Trial Findings
Neurologyataxia-telangiectasiaclinical trial

Levacetylleucine Shows Promising Safety and Efficacy in Treating Ataxia-Telangiectasia: Phase 3 Trial Findings

By MedXY|Jul 8, 2026

A phase 3 randomized, placebo-controlled crossover trial demonstrates that levacetylleucine significantly improves neurological function in ataxia-telangiectasia patients with a favorable safety profile.

Decompressive Craniectomy vs. Standard Craniotomy for Large Acute Epidural Hematoma with Tentorial Herniation: Insights from the PREDICT-AEDH Trial in China
Critical Careclinical trialEpidural Hematoma

Decompressive Craniectomy vs. Standard Craniotomy for Large Acute Epidural Hematoma with Tentorial Herniation: Insights from the PREDICT-AEDH Trial in China

By MedXY|Jul 4, 2026

A nationwide randomized trial shows decompressive craniectomy does not improve functional outcomes over standard craniotomy but increases delayed intracranial hemorrhage risk in patients with large acute epidural hematoma and tentorial hern

Safety and Efficacy of Staged, Bilateral MRgFUS Pallidothalamic Tractotomy in Parkinson’s Disease Motor Complications: A Contemporary Evidence Review
Clinical Updatesclinical trialmotor complications

Safety and Efficacy of Staged, Bilateral MRgFUS Pallidothalamic Tractotomy in Parkinson’s Disease Motor Complications: A Contemporary Evidence Review

By MedXY|Jul 3, 2026

This review synthesizes evidence on staged, bilateral MRgFUS pallidothalamic tractotomy for Parkinson’s motor complications, highlighting demonstrated unilateral safety and modest bilateral efficacy with increased adverse events, unde

Breakthrough Optogenetic Therapy UGX-201 Shows Promise for Advanced Retinitis Pigmentosa
newsclinical trialoptogenetic therapy

Breakthrough Optogenetic Therapy UGX-201 Shows Promise for Advanced Retinitis Pigmentosa

By MedXY|Jul 2, 2026

An exploratory trial of UGX-201, a novel optogenetic therapy, demonstrated safety and meaningful visual improvements in patients with advanced nonsyndromic retinitis pigmentosa, including restoration of light perception in those previously

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