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Elevated baseline CRP levels in older acute HF patients identify those who gain the most physical function improvement from a 12-week rehabilitation program, supporting biomarker-guided therapy.
The DECISION trial demonstrated that discontinuation of low-dose digoxin in heart failure patients optimized on guideline therapy leads to increased heart failure events and clinical deterioration, supporting cautious withdrawal decisions.
This article explores how baseline aldosterone concentrations influence the efficacy and outcomes of mineralocorticoid receptor antagonists (MRAs) in heart failure patients, highlighting the need for tailored therapeutic approaches.
Transseptal transcatheter mitral valve replacement with the SAPIEN M3 system in patients with symptomatic mitral annular calcification shows sustained mitral regurgitation reduction, improved functional status, and meaningful quality-of-lif
The 2026 Second Universal Definition standardizes HF terminology, reframes ejection-fraction categories, formalizes pre-HF and dynamic HF trajectories, and offers a global, cause-based classification to improve prevention, diagnosis, resear
A subcutaneous furosemide minipump-enabled early discharge strategy improves days alive and out of hospital in heart failure patients, reducing inpatient stay without increasing serious adverse events significantly.
Prominent left atrial V waves in heart failure with preserved ejection fraction significantly increase right ventricular afterload independent of pulmonary vascular disease, challenging current hemodynamic assessments and impacting patient
This article explores how palmitic acid induces a pro-hypertrophic memory in cardiomyocytes through epigenetic regulation involving KDM5A and H3K4me3 modifications, driving cardiac hypertrophy and heart failure, and highlights potential the
Transcatheter tricuspid-valve repair plus medical therapy significantly improves survival, reduces heart failure hospitalizations, and enhances quality of life in patients with severe tricuspid regurgitation compared to medical therapy alon
The CONDUCT-AF trial demonstrated that conduction system pacing is non-inferior to biventricular pacing for improving LVEF at 6 months in patients with refractory AF and HF undergoing AV node ablation, with procedural advantages favoring CS
Most heart failure patients harbor multiple cardiovascular-kidney-metabolic conditions, which independently escalate mortality and readmission risk, especially in HFrEF, underscoring the need for integrated management strategies tailored by
A practical, clinician-focused summary of the 2026 European Heart Journal consensus on implementing cardiac magnetic resonance (CMR) across common cardiac diseases, highlighting indications, protocols, prognostic use, device safety, and wor
Extremely high NT-proBNP levels in hospitalized patients often indicate infection rather than heart failure, with a high mortality risk; interpretation requires comprehensive clinical context.
This trial evaluated whether atrioventricular node ablation improves outcomes of cardiac resynchronization therapy in heart failure patients with permanent atrial fibrillation, finding no significant benefit over medical rate control.
The SUSTAIN-IT study reveals variable improvements in health-related quality of life over two years following heart transplantation or long-term mechanical circulatory support in older heart failure patients, highlighting important consider
This article explores the integration of evidence-based medicine and personalized approaches in managing heart failure and inherited cardiomyopathies, proposing a framework to optimize patient care by harmonizing standardized guidelines wit
This study reveals how cardiac resynchronization therapy (CRT) improves left ventricular function in heart failure patients and modulates systemic metabolomic profiles, highlighting differences between ischemic and nonischemic cardiomyopath
The PORTHOS study reveals a 16.5% prevalence of heart failure among Portuguese adults aged 50+, with HFpEF constituting over 90% of cases, mostly undiagnosed, highlighting the need for enhanced screening strategies in aging populations.
A prospective study reveals that ultra-rare cardiomyopathy gene variants significantly increase risk for early heart failure in infants with hypoplastic left heart syndrome, highlighting potential for genetic risk stratification and precisi
The LIFE-Preserved model accurately predicts short-term and lifetime risks of heart failure hospitalization or cardiovascular death in HFpEF patients, enabling tailored clinical risk stratification and improved management.
