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Unlocking the Potential of Novel Biomarkers for Acute Kidney Injury in the Critically Ill: A Comprehensive Evidence Mapping
Critical Carecritical carebiomarkers

Unlocking the Potential of Novel Biomarkers for Acute Kidney Injury in the Critically Ill: A Comprehensive Evidence Mapping

By MedXY|Sep 18, 2026

This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.

Blood Transcriptomic Signatures as Predictors of Poor Outcomes in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Brazilian Cohort
Infectious Diseasestranscriptomics
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tuberculosis

Blood Transcriptomic Signatures as Predictors of Poor Outcomes in Drug-Susceptible Pulmonary Tuberculosis: Insights from a Brazilian Cohort

By MedXY|Sep 17, 2026

Host blood transcriptomic signatures effectively monitor treatment response and predict recurrence and mortality in drug-susceptible pulmonary tuberculosis, meeting WHO benchmarks and enabling personalized therapy strategies.

Advancing Fetal Death Detection: Identification of Novel Maternal Plasma Biomarkers Through Large-Scale Proteomic Profiling
newspreeclampsiamaternal plasma

Advancing Fetal Death Detection: Identification of Novel Maternal Plasma Biomarkers Through Large-Scale Proteomic Profiling

By MedXY|Sep 12, 2026

Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.

Decoding Neuroendocrine Carcinomas: Proteomic Insights Define Subtypes, Biomarkers, and Therapeutic Opportunities
Gastroenterologytargeted therapyNAD+ metabolism

Decoding Neuroendocrine Carcinomas: Proteomic Insights Define Subtypes, Biomarkers, and Therapeutic Opportunities

By MedXY|Aug 28, 2026

Comprehensive proteomic and phosphoproteomic profiling of 267 neuroendocrine carcinomas across multiple tissues reveals distinct molecular subtypes, biomarkers, and a novel NAD+ metabolic vulnerability, advancing personalized precision medi

Plasma POMC as a Predictive Biomarker for Silent Corticotroph Adenomas in Non-Functioning Pituitary Tumors
Diabetes & EndocrinologyACTH precursorsSilent corticotroph adenomas

Plasma POMC as a Predictive Biomarker for Silent Corticotroph Adenomas in Non-Functioning Pituitary Tumors

By MedXY|Aug 27, 2026

Elevated plasma pro-opiomelanocortin (POMC) levels accurately predict silent corticotroph adenomas (SCAs) among clinically non-functioning pituitary adenomas, offering a promising tool for diagnosis and monitoring.

Refining Treatment Monitoring in Patients With Relapsing Multiple Sclerosis Based on Changes on Neurofilament Light Chain Z-Scores
Clinical Updatesmultiple sclerosisTreatment monitoring

Refining Treatment Monitoring in Patients With Relapsing Multiple Sclerosis Based on Changes on Neurofilament Light Chain Z-Scores

By MedXY|Aug 21, 2026

Serum neurofilament light chain (sNfL) z-score dynamics enhance monitoring of treatment response in relapsing multiple sclerosis (RMS), providing complementary predictive value for disease activity beyond conventional clinical and MRI asses

Plasma Biomarkers for Neocortical Tau Burden
Neurologyタウ病理Plasma Proteins

Plasma Biomarkers for Neocortical Tau Burden

By MedXY|Aug 15, 2026

A multiprotein plasma panel improves detection of advanced neocortical tau pathology in Alzheimer’s disease risk individuals beyond p-tau217 alone, enhancing patient stratification and clinical trial selection.

New Insights into Artificial Sweeteners and Emulsifiers in Crohn’s Disease: Biomarkers and Metabolic Mechanisms from the ENIGMA Study
GastroenterologyCrohn’s diseaseemulsifiers

New Insights into Artificial Sweeteners and Emulsifiers in Crohn’s Disease: Biomarkers and Metabolic Mechanisms from the ENIGMA Study

By MedXY|Aug 14, 2026

The ENIGMA study reveals altered metabolism of the emulsifier polysorbate-80 and elevated artificial sweeteners in Crohn’s disease, linking these dietary additives to disease activity and potential biomarker development.

Serum Glial Fibrillary Acidic Protein Dynamics in Multiple Sclerosis: Biomarker Insights into Disease Progression and Therapeutic Response
Clinical Updatesmultiple sclerosisGFAP

Serum Glial Fibrillary Acidic Protein Dynamics in Multiple Sclerosis: Biomarker Insights into Disease Progression and Therapeutic Response

By MedXY|Aug 4, 2026

Serum GFAP elevation predicts progression independent of relapse in MS; therapy-induced GFAP reduction associates with decreased progression risk, supporting GFAP as a biomarker for progression risk stratification and treatment monitoring.

STARDaki: Standardizing How We Report Acute Kidney Injury Biomarker Studies
Critical CareAKIbiomarkers

STARDaki: Standardizing How We Report Acute Kidney Injury Biomarker Studies

By MedXY|Jul 30, 2026

An expert consensus (STARDaki) extends STARD to improve reporting of diagnostic test accuracy studies for acute kidney injury (AKI), specifying patient selection, reference standards, timing, assay details and test-retest reliability.

Tomographic Predictors of Foveal Versus Extrafoveal Atrophy Onset in Intermediate Age-Related Macular Degeneration: Clinical Implications and Biomarker Insights
Clinical UpdatesbiomarkerscRORA

Tomographic Predictors of Foveal Versus Extrafoveal Atrophy Onset in Intermediate Age-Related Macular Degeneration: Clinical Implications and Biomarker Insights

By MedXY|Jul 13, 2026

Distinct baseline foveal tomographic lesions predict foveal-first versus extrafoveal-first cRORA onset in iAMD. Hyperreflective foci and lesion type inform risk stratification and timing of atrophic progression relevant for emerging dry AMD

Advancing Early Detection of Nasopharyngeal Carcinoma: Evaluating the Novel Anti-BNLF2b Antibody Test
newsbiomarkersearly detection

Advancing Early Detection of Nasopharyngeal Carcinoma: Evaluating the Novel Anti-BNLF2b Antibody Test

By MedXY|Jul 11, 2026

This article critically appraises a multicenter study validating the Anti-BNLF2b antibody (P85-Ab) assay, highlighting its superior sensitivity and specificity for early nasopharyngeal carcinoma detection compared to established EBV-based b

Plasma Oxytocin as a Superior Preoperative Biomarker for Predicting Transient Postoperative Arginine Vasopressin Deficiency Following Transsphenoidal Pituitary Surgery
Diabetes & EndocrinologyArginine Vasopressin Deficiencybiomarkers

Plasma Oxytocin as a Superior Preoperative Biomarker for Predicting Transient Postoperative Arginine Vasopressin Deficiency Following Transsphenoidal Pituitary Surgery

By MedXY|Jul 10, 2026

This study identifies plasma oxytocin as a superior preoperative biomarker compared to copeptin for early prediction of transient arginine vasopressin deficiency after transsphenoidal pituitary surgery, aiding in risk stratification and pos

Integrated Intraocular and Plasma Proteomics Identify Neurofilament Light Chain as a Conserved Biomarker for Diabetic Retinopathy Progression: A Multi-Fluid Biopsy Perspective
Clinical Updatesbiomarkersproteomics

Integrated Intraocular and Plasma Proteomics Identify Neurofilament Light Chain as a Conserved Biomarker for Diabetic Retinopathy Progression: A Multi-Fluid Biopsy Perspective

By MedXY|Jul 1, 2026

This review synthesizes evidence on neurofilament light chain (NFL) as a minimally invasive plasma biomarker predictive of diabetic retinopathy progression and vascular complications, based on integrated intraocular-plasma proteomics and mu

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial
Cardiologybiomarkerschết đột ngột

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial

By MedXY|Jun 20, 2026

This study reveals that sudden death in heart failure patients often follows gradual clinical decline, challenging the notion that such deaths are always abrupt.

New Genetic Modifiers in Autosomal Dominant Alzheimer’s Disease Link Aβ, Tau, TDP-43, and Vascular Biology to Clinical Variability
Neurologyautosomal dominant Alzheimer’s diseasebiomarkers

New Genetic Modifiers in Autosomal Dominant Alzheimer’s Disease Link Aβ, Tau, TDP-43, and Vascular Biology to Clinical Variability

By MedXY|Jun 3, 2026

A genome-wide association study identified CNIH4, CCNG1, and RHOJ as genetic modifiers of autosomal dominant Alzheimer’s disease, with associations spanning disease risk, age at onset, fluid biomarkers, and neuroimaging phenotypes.

Elevated Von Willebrand Factor and Factor VIII Show Promise as Biomarkers for Diagnosis and Monitoring of Chronic Graft-Versus-Host Disease
Hematology-Oncologybiomarkerschronic graft-versus-host disease

Elevated Von Willebrand Factor and Factor VIII Show Promise as Biomarkers for Diagnosis and Monitoring of Chronic Graft-Versus-Host Disease

By MedXY|May 27, 2026

In a prospective cohort, VWF and FVIII were significantly elevated in chronic graft-versus-host disease, tracked with disease activity, and showed moderate diagnostic performance for early cGvHD.

Beyond Neuronal Injury: Serum Neurofilament Light Chain as a Prognostic Biomarker for Cardiovascular Outcomes in Atrial Fibrillation
Cardiologyatrial fibrillationbiomarkers

Beyond Neuronal Injury: Serum Neurofilament Light Chain as a Prognostic Biomarker for Cardiovascular Outcomes in Atrial Fibrillation

By MedXY|May 18, 2026

This review analyzes the landmark SWISS-AF study, demonstrating that serum neurofilament light chain (sNfL), traditionally a marker of neuronal damage, is a potent independent predictor of major vascular events, heart failure, and mortality

Why the cTnI/cTnT Ratio May Matter: A New Signal for Distinguishing Acute Necrotic From Chronic Myocardial Injury
CardiologybiomarkersCardiac troponin

Why the cTnI/cTnT Ratio May Matter: A New Signal for Distinguishing Acute Necrotic From Chronic Myocardial Injury

By MedXY|May 12, 2026

A large multicohort and experimental study suggests the cTnI/cTnT ratio is biologically informative, separates acute from chronic myocardial injury, and modestly improves type 1 versus type 2 MI discrimination.

Continuous Subphenotype Probabilities Expose High-Risk Patients Hidden Within “Hypoinflammatory” Acute Respiratory Failure
Critical CareAcute Hypoxemic Respiratory FailureARDS subphenotypes

Continuous Subphenotype Probabilities Expose High-Risk Patients Hidden Within “Hypoinflammatory” Acute Respiratory Failure

By MedXY|May 5, 2026

AHRF patients classified as hypoinflammatory are not prognostically uniform. Continuous biomarker-based probabilities reveal substantial mortality heterogeneity, especially below the binary 0.5 threshold, with implications for enrichment st

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