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MedXY AI/MedXY News/Tag: Transthyretin Cardiac Amyloidosis
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Transthyretin Cardiac Amyloidosis

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Consistent Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis Amidst Concomitant Disease-Modifying Therapies
CardiologyDisease-Modifying TherapyHELIOS-B trial

Consistent Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis Amidst Concomitant Disease-Modifying Therapies

By MedXY|Sep 3, 2026

The HELIOS-B trial demonstrates that vutrisiran significantly reduces mortality and cardiovascular events in ATTR-CM patients, with its efficacy unaffected by concurrent use of tafamidis or heart failure medications, supporting its broad th

Vutrisiran and Tafamidis in Transthyretin Amyloidosis Cardiomyopathy: Evaluating Combination Therapy Insights from HELIOS-B
CardiologyATTR-CM
RNA 干扰

Vutrisiran and Tafamidis in Transthyretin Amyloidosis Cardiomyopathy: Evaluating Combination Therapy Insights from HELIOS-B

By MedXY|Sep 1, 2026

The HELIOS-B trial showed vutrisiran improves survival and cardiac outcomes in transthyretin amyloidosis with cardiomyopathy, with consistent benefits regardless of baseline tafamidis use, supporting further evaluation of combination therap

Right Ventricular Function, Clinical Outcomes, and Effect of Vutrisiran in Transthyretin Amyloidosis With Cardiomyopathy: Insights from the HELIOS-B Trial
CardiologyHELIOS-B trialright ventricular dysfunction

Right Ventricular Function, Clinical Outcomes, and Effect of Vutrisiran in Transthyretin Amyloidosis With Cardiomyopathy: Insights from the HELIOS-B Trial

By MedXY|Aug 28, 2026

This review synthesizes evidence on the prevalence and prognostic value of right ventricular dysfunction in ATTR-CM and the therapeutic impact of vutrisiran on RV function from the HELIOS-B trial, underscoring RV free wall strain as a key b

Left Atrial Dysfunction and Vutrisiran Efficacy in Transthyretin Amyloid Cardiomyopathy: Insights from the HELIOS-B Trial
Cardiologyleft atrial dysfunctioncardiomyopathy

Left Atrial Dysfunction and Vutrisiran Efficacy in Transthyretin Amyloid Cardiomyopathy: Insights from the HELIOS-B Trial

By MedXY|Aug 21, 2026

This article reviews the prognostic role of left atrial dysfunction in transthyretin amyloid cardiomyopathy and evaluates vutrisiran’s impact on atrial function and clinical outcomes based on a secondary analysis of the HELIOS-B phase 3 tri

Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis
Cardiologyheart failureTransthyretin Cardiac Amyloidosis

Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis

By MedXY|Mar 7, 2026

This large retrospective study of 820 patients reveals that restrictive ventricular physiology is the most common phenotype in cardiac amyloidosis. While preserved LV function offers better initial survival, the rate of progression to restr

Tracking the Invisible: CMR-ECV Mapping Reveals Amyloid Stabilization with Patisiran and Predicts Mortality in ATTR-CM
CardiologyCMRTransthyretin Cardiac Amyloidosis

Tracking the Invisible: CMR-ECV Mapping Reveals Amyloid Stabilization with Patisiran and Predicts Mortality in ATTR-CM

By MedXY|Jan 3, 2026

A landmark study demonstrates that CMR-derived extracellular volume (ECV) mapping effectively monitors amyloid burden in ATTR-CM. While untreated patients show significant progression, patisiran stabilizes amyloid load, with ECV progression

A Unified High-Sensitivity Cardiac Troponin I Threshold of 80 ng/L for Risk Stratification in Wild-Type Transthyretin Amyloid Cardiomyopathy
Cardiologyheart failurerisk stratification

A Unified High-Sensitivity Cardiac Troponin I Threshold of 80 ng/L for Risk Stratification in Wild-Type Transthyretin Amyloid Cardiomyopathy

By MedXY|Dec 24, 2025

This multicenter study identifies high-sensitivity cardiac troponin I (hs-cTnI) as a potent, independent predictor of mortality in wild-type transthyretin amyloid cardiomyopathy. A universal threshold of 80 ng/L, integrated with natriuretic

Dual Pathology No Longer a Dead End: Tafamidis and AVR Improve Survival in Aortic Stenosis with Cardiac Transthyretin Amyloidosis
Cardiologyaortic stenosistafamidis

Dual Pathology No Longer a Dead End: Tafamidis and AVR Improve Survival in Aortic Stenosis with Cardiac Transthyretin Amyloidosis

By MedXY|Nov 29, 2025

In a multinational registry of patients with concomitant aortic stenosis (AS) and transthyretin cardiac amyloidosis (ATTR‑CA), both ATTR‑specific therapy (predominantly tafamidis) and aortic valve replacement (AVR) were independently associ

Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Patients with Heart Failure: Prevalence, Genetics, and Clinical Implications
Cardiologyheart failureHispanic population

Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Patients with Heart Failure: Prevalence, Genetics, and Clinical Implications

By MedXY|Oct 9, 2025

A prospective study reveals transthyretin cardiac amyloidosis (ATTR-CA) affects a significant proportion of older Black patients with heart failure, especially men over 75, with nearly half linked to the V142I genetic variant. Hispanic prev

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