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This study examines how cardiac MRI postprocessing methods, including trabeculation exclusion and pulmonary artery flow measurement sites, significantly influence right ventricular volume and function assessment in pulmonary hypertension pa
This study reveals unique fatty acid and oxylipin metabolic signatures that differentiate isolated postcapillary pulmonary hypertension from combined pre- and postcapillary PH, highlighting potential biomarkers and therapeutic targets.
This article explores how PUS7-induced pseudouridylation of TGFBI mRNA promotes pulmonary hypertension via epigenetic regulation, revealing promising new therapeutic targets.
This multicenter study validates the Venous Excess Ultrasound Score (VExUS) as a highly accurate, noninvasive tool to predict right atrial pressure in patients evaluated for pulmonary hypertension, outperforming isolated echocardiographic m
This study reveals that pulmonary artery stiffness and right ventricular function parameters independently predict mortality better than pulmonary vascular resistance in mild pulmonary hypertension, supporting their role in early disease ri
This study integrates vascular mechanics, advanced imaging, and myocardial transcriptomics to elucidate the mechanisms of right ventricular failure in pulmonary hypertension secondary to heart failure with preserved ejection fraction, uncov
BACH1 stabilization under hypoxia promotes pulmonary hypertension by enhancing TGFBR2/SMAD pathway activity in pulmonary artery smooth muscle cells, suggesting BACH1 as a promising therapeutic target for PH.
A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.
Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.
CT-derived pulmonary vascular metrics, especially the small-artery to total arterial volume ratio, identify severe pulmonary hypertension in chronic lung disease, with distinct vascular remodeling patterns in COPD and fibrosing ILD.
In CTEPH patients undergoing balloon pulmonary angioplasty, dual pulmonary hypertension-targeted pretreatment was linked to fewer thoracic complications and better 6-month clinical improvement than monotherapy.
Emerging evidence identifies a bidirectional link between breast cancer and pulmonary arterial hypertension (PAH) driven by BMPR2 signaling and IL-1β-mediated inflammation. This study suggests breast cancer may serve as a critical second hi