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A large-scale longitudinal study reveals that ICU survivors aged 60–79 face significantly higher 5-year excess mortality and functional decline compared to the general population, whereas outcomes for nonagenarians converge with their peers
A large-scale study of over 700,000 young adults reveals a concerning decline in lipid follow-up and statin initiation between 2008 and 2018, highlighting a critical care gap in preventing premature cardiovascular disease during a key windo
A Norwegian population-based study of 492 women aged 18-22 reveals significant inter-individual variability in ovarian volume, antral follicle count, and AMH levels, providing a critical baseline for understanding reproductive health before
The FLUNITY-HD pooled analysis of over 466,000 older adults demonstrates that high-dose inactivated influenza vaccine (HD-IIV) significantly reduces hospitalizations for influenza, pneumonia, and cardiovascular causes, including a 21.3% red
A global Heart Rhythm Society survey reveals that 41% of EP professionals suffer from orthopedic injuries and 50% of women face pregnancy complications, highlighting the urgent need for systemic improvements in laboratory ergonomics and rad
This study identifies key modifiable surgical and hospital-level factors—including surgical approach and antibiotic adherence—that contribute to the disproportionately higher rate of postoperative complications experienced by Black patients
An mHealth text messaging intervention significantly improves smoking cessation rates and reduces mortality among TB patients compared to usual care, supporting its implementation in TB programs.
The U.S. Senate’s unanimous passage of the FDA Modernization Act 3.0 marks a definitive shift in drug regulation, formally replacing ‘animal’ mandates with ‘nonclinical’ methodologies like organ-on-a-chip and A
A comprehensive population study of 450,453 deaths identifies specific occupations, including fishing, mining, and funeral services, with disproportionately high cancer mortality, suggesting a complex interplay of workplace exposures and st
From 2010 to 2019, NCD mortality declined in 80% of countries worldwide, driven primarily by reductions in circulatory diseases, with notable regional and cause-specific heterogeneity and slower progress than the previous decade.
A 4-year randomized controlled trial found that computer-generated feedback letters failed to reduce alcohol consumption in the general population. Unexpectedly, the control group showed greater reduction at 48 months, suggesting that curre
This randomized clinical trial compares 100-mg and 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence among patients with high-frequency fentanyl
A new influenza strain, Subclade K (AH3N2 J.2.4.1), is dominating Europe’s flu season with a 90% prevalence rate. Experts emphasize that while the strain is highly transmissible, vaccination remains the most effective tool for prevent
This randomized clinical trial compares 100-mg versus 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence rates among heavy fentanyl users, offeri
A systematic review of 347 randomized trials reveals that non-industry-sponsored trials lag significantly behind industry counterparts in registration and results publication, with nearly one-third of all trials discontinued prematurely due
A 47-year study shows physical capacity peaks in the late 20s–30s and accelerates downward from about age 40 — but regular exercise, started at any age, can meaningfully delay decline.
The DANFLU-2 trial found that while high-dose influenza vaccines significantly reduced influenza-specific hospitalizations in older adults, they did not reach statistical significance for the combined primary endpoint of influenza or pneumo
This review examines the safety and effectiveness of electronic cigarettes as aids to quit smoking, showing increased abstinence rates compared to traditional therapies and no significant serious adverse events reported.
Updated Cochrane review finds nicotine e-cigarettes increase smoking cessation success compared to NRT and non-nicotine e-cigarettes, with no clear difference in serious adverse events.
A large network meta‑analysis confirms HPV vaccines effectively reduce CIN2+ and anogenital warts, with no major safety concerns.
