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Long-Term Opioid Use After Radiation Therapy in Head and Neck Cancer: Prevalence, Risk Factors, and Clinical Implications

MedXY Editorial TeamOct 6, 2026
head and neck cancerOpioid StewardshipOpioid Useradiation therapy

Highlight

  • Approximately 70% of patients with head and neck cancer continued opioid use at 3 months post-radiation or chemoradiation, with nearly half still using opioids at 6 months.
  • Key factors associated with persistent opioid use include prior opioid use, former smoking status, and referral to palliative care.
  • Among opioid-naive patients prior to radiation, those who were underweight or referred to palliative care experienced earlier initiation of opioid use.
  • Findings emphasize the critical need for targeted opioid stewardship programs balancing effective pain management with minimizing long-term dependency.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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