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Younger age at type 1 diabetes diagnosis significantly increases risks of mortality, cardiovascular, and kidney complications; each additional year delay in onset reduces these risks. This review synthesizes nationwide cohort findings and c
Empagliflozin consistently reduces major cardiovascular events, heart failure hospitalizations, and mortality across diverse sociodemographic and cardiovascular risk groups in older adults with type 2 diabetes, with especially pronounced ab
This study reveals that lipid profiles paradoxically worsen during the early remission phase after curative surgery for Cushing’s syndrome, highlighting a critical window for cardiovascular risk and targeted intervention.
Radiofrequency ablation (RFA) provides a safe, effective treatment for thyroid nodules in the remaining lobe after unilateral thyroid lobectomy, offering substantial volume reduction with minimal complications and preserved thyroid function
This article reviews the clinical evaluation, differential diagnosis, and treatment outcomes of patients presenting with thyroid compressive symptoms, emphasizing the importance of thorough preoperative workup and individualized surgical se
This study evaluates how different pituitary adenoma histological subtypes influence remission and disease control in acromegaly post-surgery, finding no significant differences though sparsely granulated adenomas show a trend toward lower
A multicenter German registry study comparing carboplatin/paclitaxel to other chemotherapy regimens in anaplastic thyroid cancer found no survival advantage, highlighting the importance of molecular diagnostics and multimodal treatment appr
This study reveals that despite long-term remission in Cushing’s disease, substantial plasma protein abnormalities persist, particularly in coagulation and complement systems, potentially contributing to ongoing health risks.
This study investigates three-year continuous glucose monitoring trajectories across clinical subgroups of adults with type 1 diabetes to identify factors influencing glycemic control and variability, highlighting the need for individualize
This study reveals that polyendocrine metabolic ovarian syndrome (PMOS) during pregnancy increases risks of early gestational diabetes and adverse neonatal outcomes, underscoring the need for timely identification and management to improve
A cluster-randomized trial demonstrates that integrating best practice advisories (BPAs) and standing orders into electronic health records significantly improves referral rates to diabetes self-management education and support (DSMES) over
Semaglutide demonstrates consistent cardiovascular benefits and safety across frailty levels in overweight adults with cardiovascular disease, enhancing quality of life and frailty status without increased adverse events.
This meta-analysis of 87 randomized trials finds that increasing whole-grain intake is associated with improved cardiometabolic risk factors including reduced body weight, cholesterol, and blood pressure, particularly at daily intakes of 60
This article reviews the establishment of international standardized reference ranges for plasma estradiol in postmenopausal women, highlighting the influence of BMI and assay harmonization using CDC standards, with implications for therapy
A comprehensive UK cohort study shows that GLP-1 receptor agonists do not reduce the incidence of obstructive sleep apnea compared to DPP-4 inhibitors in obese patients with type 2 diabetes.
The 2026 EASD guideline provides practical, evidence-based recommendations for routine assessment and management of diabetes distress in adults with type 1 or type 2 diabetes, including validated screening, eight Good Practice Statements, a
This article reviews a validated machine learning decision-tree model using LC-MS/MS steroid profiles to accurately and rapidly diagnose congenital disorders of adrenal steroidogenesis (CDAS), enhancing clinical decision-making and patient
A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.
SGLT2 inhibitors administered after endovascular thrombectomy in diabetic stroke patients significantly improve 3-month functional outcomes, suggesting a promising adjunctive therapy for poststroke diabetes management.
Fenofibrate use in type 2 diabetes patients is associated with a significant reduction in the risk of sight-threatening diabetic retinopathy compared to statins, based on UK primary care data over 12 years.
