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This study reveals that liver-secreted apolipoprotein J accumulates in renal tubules, disrupting TFEB-mediated lipid homeostasis and exacerbating diabetic kidney disease, highlighting a novel therapeutic target with the ApoJ antagonist MK53
A large Korean cohort study found similar hepatic benefits between empagliflozin and dapagliflozin in patients with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease, with no difference in risk of severe liver com
A 6-month RCT in non-insulin-treated type 2 diabetes demonstrates that combining the digital therapeutic glucura with CGM significantly improves HbA1c, weight, and patient well-being beyond CGM and standard care alone.
Individualized cabergoline dosing guided by nadir prolactin levels achieves durable remission and safe pregnancy outcomes in women with prolactinomas, including those resistant or intolerant to bromocriptine.
This study identifies baseline plasma metabolites, specifically 2hr plasma glucose and ceramide C18:0/C18:1 ratio, as predictors of persistent prediabetes vs. normoglycemia following lifestyle intervention over 5 years.
An indirect comparison shows tirzepatide significantly reduces major adverse cardiovascular events and mortality in type 2 diabetes patients, highlighting its potential for improving cardiovascular outcomes.
In early pregnancy, adding oral glucose tolerance testing or continuous glucose monitoring to clinical factors improves prediction of gestational diabetes mellitus but not large-for-gestational-age births.
This review synthesizes evidence linking in utero exposure to preexisting and gestational diabetes with increased diabetes incidence in offspring, highlighting stronger effects among First Nations populations and the mitigating role of peri
The DIABIL-2 trial evaluated low-dose IL-2 therapy for preserving β-cell function in new-onset type 1 diabetes. Despite marked Treg expansion and good safety, IL-2 did not significantly preserve insulin secretion compared to placebo.
This study highlights the prevalence, clinical features, and management challenges of immune-related thyroid and diabetes toxicities in gynecologic cancer patients treated with immunotherapy, emphasizing the need for proactive endocrine mon
This study quantifies thyroid ultrasound use following incidental thyroid nodule detection and identifies factors influencing downstream evaluation, highlighting opportunities to optimize care and reduce unnecessary interventions.
GAD-alum immunotherapy significantly delays progression to stage 3 type 1 diabetes in children positive for the HLA-DR3-DQ2 haplotype, underscoring precision medicine’s role in managing autoimmunity.
A French nationwide cohort study finds first-trimester exposure to second-line glucose-lowering agents, including GLP-1 receptor agonists, is generally safe for pregnancies with type 2 diabetes, though a slight increase in cardiac malformat
This study validates morning salivary cortisone as an accurate, non-invasive alternative to serum cortisol for adrenal insufficiency screening, proposing actionable diagnostic thresholds to aid clinical decision-making.
A no-code, agentic AI workflow successfully developed and externally validated a calibrated thyroid nodule malignancy classifier, demonstrating strong diagnostic performance across multiple cancer histologies and enhancing accessibility in
Metabolic status, reflected by glycemic trajectories, significantly modifies the skeletal response to active vitamin D analog eldecalcitol, with greater BMD improvements observed in individuals regressing from prediabetes to normoglycemia.
This study highlights the limitations of insulin dose-adjusted hemoglobin A1c (IDAA1c) ≤9 in detecting partial remission in US youth with type 1 diabetes, especially those with overweight or obesity, suggesting BMI-specific adjustments impr
This review synthesizes evidence from the DCCT/EDIC study highlighting the high prevalence and risk factors of obstructive sleep apnea and poor sleep quality in older adults with long-standing type 1 diabetes, emphasizing the clinical and m
Petrelintide, a novel once-weekly human amylin analogue, demonstrates significant bodyweight reduction versus placebo in adults with obesity, with favorable gastrointestinal tolerability, supporting its potential as a long-term obesity ther
Updated meta-analysis reveals modest HbA1C improvements with behavioral interventions in youth with type 1 diabetes, highlighting the superiority of family-focused, multicomponent approaches over single-focus programs.
