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A novel protocol performing diagnostic 131I scans within 24 hours after the second rhTSH injection reliably guides radioiodine therapy in differentiated thyroid cancer, enabling same-cycle pre-treatment evaluation and treatment without sche
European experts recommend designated centers, structured diagnostic pathways, and real‑world monitoring to deliver precision therapies (MC4R agonists) safely and equitably to people with rare genetic forms of obesity.
A comprehensive European cohort study reveals that Helicobacter pylori infection’s association with insulin resistance is confounded by socioeconomic and lifestyle factors, arguing against its independent causal role and the need for
A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.
A phase 3 trial demonstrated that HTD1801 monotherapy significantly reduces HbA1c and improves cardiometabolic and inflammatory markers in patients with inadequately controlled type 2 diabetes, with sustained effects and a favorable safety
Iatrogenic hypercalcemia complicates 14% of hypoparathyroidism cases post-total thyroidectomy, linked to low early postoperative parathyroid hormone and early vitamin D initiation. Careful supplementation and monitoring are vital in prevent
This population-wide study demonstrates that parathyroidectomy in primary hyperparathyroidism reduces major adverse cardiovascular events risk, particularly in patients with higher serum calcium levels.
African adults with type 2 diabetes who are lean exhibit distinct complication profiles characterized by higher retinopathy and stroke risk but lower hypertension and cardiovascular disease risk compared to their overweight/obese counterpar
This article reviews data-driven diabetes subtypes in East Asians, highlighting unique pathological features, genetic influences, and complication risks, emphasizing personalized treatment strategies for optimized care.
Islet autoantibody positivity varies significantly among racial and ethnic groups and is influenced by socioeconomic deprivation, implicating tailored screening and prevention strategies for equitable diabetes care.
Early weight loss after impaired glucose tolerance diagnosis is linked to markedly reduced long-term risk of cardiovascular events and death, underscoring the importance of early lifestyle interventions in prediabetes management.
This study reveals how genetic risk for diabetic retinopathy can be significantly mitigated by healthy lifestyle choices, emphasizing universal behavioral interventions for prevention.
This article reviews challenges and management strategies for achieving pregnancy in women with 21-hydroxylase deficiency congenital adrenal hyperplasia, emphasizing hormonal normalization and individualized glucocorticoid therapy.
Octreotide shows potential as an effective adjunctive therapy in catecholamine-secreting pheochromocytomas and paragangliomas, improving biochemical, hemodynamic, and metabolic parameters and supporting perioperative management.
This study highlights the high recurrence of gestational diabetes mellitus (GDM) and its strong association with future type 2 diabetes, particularly among Asian women, underscoring the need for ethnicity-specific prevention and screening s
Baricitinib treatment in recent-onset type 1 diabetes preserves β-cell function during therapy. However, this effect diminishes within a year after stopping treatment, highlighting the need for sustained immunotherapy for lasting benefit.
Mazdutide, a once-weekly glucagon and GLP-1 receptor dual agonist, delivers clinically meaningful weight reduction in adults with obesity or overweight, with higher doses yielding superior outcomes and manageable safety profiles.
The TARTAN-HF trial demonstrated that targeted natriuretic peptide screening in high-risk diabetic patients uncovers a high prevalence of undiagnosed heart failure, mainly HFpEF, enabling earlier treatment initiation and improved clinical c
In the SELECT trial, semaglutide significantly lowered hsCRP levels and major cardiovascular events in patients with established atherosclerotic cardiovascular disease and overweight or obesity, suggesting inflammation reduction as a possib
In type 2 diabetes patients with coronary artery disease, suPAR levels remain unchanged despite treatment and independently predict adverse cardiovascular events beyond hs-CRP, highlighting suPAR’s potential in identifying treatment-r
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