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Two large randomized trials reveal that testosterone therapy improves sexual function and mood without increasing cardiovascular risks in men with age-related low testosterone, but does not enhance vitality or physical function.
This UK Biobank study reveals that moderate and vigorous incidental physical activity significantly reduce type 2 diabetes risk, with vigorous activity providing greater benefits per minute than lower intensities.
This article reviews the incidence of inadvertent parathyroidectomy during thyroidectomy, identifies key risk factors, and discusses clinical significance and emerging strategies for parathyroid preservation.
Postbariatric hypoglycemia (PBH) is linked to rapid gastric emptying after Roux-en-Y gastric bypass. GLP-1 receptor agonists slow gastric emptying but do not prevent hypoglycemia, highlighting complex metabolic mechanisms in PBH management.
In the SELECT trial, baseline clinical factors poorly predicted peak body weight loss with semaglutide, highlighting the role of sex and dosage but underscoring substantial unexplained variability in patient response.
This review synthesizes evidence comparing diabetes duration and advanced complications between patients undergoing revascularization for lower extremity artery disease (LEAD) and coronary artery disease (CAD), highlighting the heavier diab
Automated insulin delivery (AID) systems, while transformative for type 1 diabetes management, currently lack pregnancy-specific adaptations, leaving a critical gap in care. This article highlights the urgent need to include pregnant women
The SELECT trial demonstrates semaglutide’s 20% reduction in major cardiovascular events in adults with obesity and cardiovascular disease. Mediation analysis reveals partial but uncertain roles of weight, inflammation, and glycemic m
This study assesses how often parathyroidectomy yields clinically meaningful improvements in bone mineral density, with or without adjuvant bisphosphonate treatment in patients with primary hyperparathyroidism.
This study reveals that COPD poses a greater risk to bone health than T2DM, with combined COPD and T2DM further increasing osteoporosis and fracture risk, especially in men, emphasizing the need for targeted bone health screening.
This article evaluates strategies for interpreting consecutive aldosterone-to-renin ratio tests in primary aldosteronism diagnosis, highlighting the diagnostic trade-offs and guiding clinical decision-making based on discordant or concordan
An explainable machine learning model identifies bariatric surgery candidates at risk for obesity hypoventilation syndrome using seven accessible clinical variables, enhancing early diagnosis and perioperative risk management.
A 5-year real-world cohort study reveals that declines in CGM-derived time in range correlate with increased microvascular complications in type 1 diabetes, offering prognostic value beyond HbA1c.
This report discusses four patients with paternally inherited 15q11.2-q13 duplications linked to MKRN3 overexpression, presenting with delayed puberty and varying degrees of hypogonadism.
Long-read sequencing (LRS) improves genetic diagnosis of Congenital Adrenal Hyperplasia and other DSDs by resolving complex genomic variants, tightening phenotype-genotype correlations, and closing equity gaps in clinical care.
A focused summary of the 2026 international position statement offering practical, safety-first recommendations for continuing or initiating continuous glucose monitoring, insulin pumps, and automated insulin delivery in non‑critically ill
This study highlights how daily feelings of guilt are central drivers of negative emotional burdens in diabetes, influencing emotional well-being and risk of distress and depression.
This study uses longitudinal modeling to compare tirzepatide and semaglutide’s effects on fasting glucose in type 2 diabetes, revealing tirzepatide’s superior control largely due to greater insulin-independent hepatic glucose production sup
This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond p
An international study of 715 pediatric patients with differentiated thyroid carcinoma identifies key predictors of invasive disease and demonstrates stable outcomes despite recent therapy deintensification.
