Section
A large propensity-matched cohort study found that baseline SGLT2 inhibitor use versus DPP4 inhibitor therapy in adults with type 2 diabetes and infection was associated with lower 30-day sepsis-induced cardiomyopathy and improved 1-year mo
A multinational retrospective cohort found adjunctive plasma exchange was associated with higher 28‑day transplant-free survival in amatoxin-related ALF patients with grade ≥2 hepatic encephalopathy.
In stable critically ill patients, contrast‑enhanced ultrasound (CEUS) renal perfusion metrics are reproducible; amplitude measures (RBV, PI) are more dose‑sensitive while mean transit time (mTT) shows greater robustness across infusion cha
A multicentre prospective study shows the ventricular septum curvature ratio on CTPA strongly predicts 30‑day clinical deterioration in normotensive acute pulmonary embolism, outperforming conventional single metrics and offering potential
Serial indirect calorimetry–measured hypermetabolism is independently associated with more rapid CT-quantified muscle wasting and higher risk of energy deficit in critically ill adults, suggesting personalized metabolic monitoring could gui
In 911 critically ill patients on RCA-CKRT, citrate accumulation occurred in 17%. Pre-CKRT lactate strongly predicted accumulation (OR 2.34 per 1-unit increase on log scale); VIS was less discriminatory. Accumulation linked to liver dysfunc
New persistent opioid use develops in 4.2% of opioid-naïve ICU survivors by six months post-discharge, with early opioid prescription as the strongest predictor. Risk varies by opioid potency and patient factors, highlighting tailored taper
A post‑hoc analysis of the RINO trial found rescue NIV for post‑extubation respiratory failure had a 58% failure rate but was associated with lower ICU mortality and no clear increase in hospital mortality when applied with prespecified re‑
A nationwide Japanese study of 8,184 peripartum ICU admissions (2010–2022) found hemorrhage accounted for 52.6% of cases; interventions commonly included transfusion (71.5%), mechanical ventilation (28.0%), and transcatheter arterial emboli
A single‑center RCT found that starting a titrated norepinephrine infusion at anesthesia induction reduced intraoperative hypotension and lowered 30‑day medico‑surgical complications compared with reactive ephedrine boluses in high‑risk abd
A multicenter retrospective Japanese study found that hospitals admitting more patients to ICU than predicted after rapid response activations had fewer poor neurologic outcomes or deaths within 30 days, suggesting ICU utilization after RRS
In mechanically ventilated patients with early acute hypoxemic respiratory failure, continuous IV sedation produces EEG patterns (EEG Ups) not seen in natural sleep; these patterns correlate with sedation dose, drug combinations, clinical s
A population PK–PD study in healthy volunteers found that a physiologic model incorporating CO2 kinetics and a ventilatory controller estimates fentanyl potency for ventilatory depression at ~2.3 ng/mL—substantially lower than estimates fro
A Cochrane update (2025) of 69 randomized trials found restrictive RBC transfusion thresholds (typically Hb 7–8 g/dL) cut transfusion exposure ~42% without increasing 30‑day mortality overall, but liberal strategies improved long‑term neuro
A 3-center randomized pilot trial found that randomized allocation to low- versus moderate-intensity anticoagulation during venovenous ECMO is feasible, with lower major bleeding rates in the low-intensity arm and no clear excess of thrombo
An international prospective cohort found that higher early IV fluid rates were associated with lower odds of BUN rise but higher odds of new or persistent SIRS at 6 and 24 hours after presentation, highlighting confounding issues and the n
A large international trial found that selective decontamination of the digestive tract (SDD) during mechanical ventilation did not reduce hospital mortality but decreased bloodstream infections and antibiotic-resistant organisms, with no c
A large multicenter trial demonstrated that deferring early arterial catheter insertion in ICU patients with shock is noninferior to early invasive monitoring for 28-day mortality, with fewer catheter-related complications and comparable sa
RIPK3-associated necroptosis critically drives organ failure and mortality in acute decompensation and ACLF, with its plasma levels robustly predicting outcomes and improving prognostic models to guide personalized therapies.
The UTOpiA system, integrating HLA-depleted iPSC-derived liver organoids with granulocyte-monocyte apheresis, significantly improves survival and liver regeneration in acute-on-chronic and acute liver failure rat models, representing a prom
