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Lactate Predicts Citrate Accumulation During Continuous Kidney Replacement Therapy: incidence, severity, and clinical implications

MedXY Editorial Team•Nov 6, 2025•Critical Care

Highlights

– In a retrospective cohort of 911 critically ill patients receiving regional citrate anticoagulation during continuous kidney replacement therapy (CKRT), citrate accumulation occurred in 159 patients (17%).

– Pre-CKRT arterial lactate outperformed the vasoactive inotropic score (VIS) in predicting citrate accumulation; each one-unit increase in log-transformed lactate raised odds by 2.34 (95% CI 1.94–2.85).

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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