Section
This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
An innovative, ultra-low-cost normothermic machine perfusion (NMP) system was developed and validated, enabling extended organ preservation and in vivo function in porcine and human tissues, offering affordable platforms for research and th
This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patien
This article revisits upper eyelid anatomy through operating microscope observations, revealing detailed structural relationships that enhance surgical precision in upper blepharoplasty, with implications for safer, more effective cosmetic
This review synthesizes recent evidence on machine learning models integrating multimodal data for relapse prediction in MDD, highlighting moderate accuracy driven mainly by clinical risk factors and advocating for dynamic approaches to bet
A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.
This study evaluates the sustainment of brief behavioral insomnia treatments in VA primary care mental health clinics after implementation support ended, showing increased therapy delivery and reduced sleep medication prescriptions.
This article reviews how non-alpha IL2 receptor agonist pegenzileukin can counteract CD8 T-cell exhaustion, a key mechanism in CAR T-cell (CART19) therapy failure in relapsed/refractory large B-cell lymphoma, enhancing therapeutic efficacy
This study highlights the diagnostic value of endobronchial optical coherence tomography (EB-OCT) as a complementary, low-risk imaging modality that improves confidence and diagnostic accuracy in interstitial lung disease multidisciplinary
Transitioning a traditional ophthalmology resident clinic to an urgent eye clinic model improved health equity, increased exposure to high-acuity cases, and boosted resident cataract surgery volumes in a US academic center.
Remote parent-captured oropharyngeal videos show promise for assessing tonsil size in pediatric sleep-disordered breathing, demonstrating strong interrater reliability and diagnostic accuracy comparable to in-person exams, though usability
This international multicenter study shows no significant difference in surgical complications or survival between tangential and segmental portomesenteric venous resections during pancreatoduodenectomy for pancreatic cancer with limited ve
A pharmacovigilance study using EudraVigilance data highlights potential safety signals linking desogestrel-only and drospirenone-only hormonal therapies with meningioma, underscoring the need for further longitudinal research and cautious
This article explores how acquired resistance to gemcitabine in pancreatic cancer leads to metabolic reprogramming that creates a vulnerability in the mevalonate pathway, offering a promising therapeutic target.
This article reviews a 13-year longitudinal study assessing blood-based biomarkers’ effectiveness in predicting all-cause dementia among community-dwelling older adults, highlighting their modest sensitivity and enhanced predictive value wh
An interventional study reveals testosterone’s tissue-specific effects on lipid metabolism, highlighting skeletal muscle as a critical site of metabolic disruption in male hypogonadism and its cardiometabolic implications.
The SMART-REACH2 model estimates lifetime recurrent cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease, offering region-specific recalibration and supporting personal
This study examines characteristics and reasons behind non-attendance to exercise and self-management sessions among multimorbid patients, highlighting younger age, lower self-efficacy, and depressive symptoms as key factors.
Integrated proteomic and metabolomic profiling of TMJ disease reveals nonlinear progression, molecular heterogeneity, and identifies distinct subtypes, offering a new framework for precision diagnosis and targeted therapies.
A comprehensive nationwide cohort study reveals that autograft type is not linked to revision ACL reconstruction risk in football players, with age and pre-injury playing level being stronger predictors. Notably, quadriceps tendon grafts in
