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This review synthesizes evidence from the STEP 12 trial and related studies demonstrating that once-weekly semaglutide 2.4 mg significantly reduces bodyweight and improves cardiometabolic outcomes in Chinese adults with overweight or obesit
Elevated endogenous insulin and insulin resistance independently predict progression of diastolic dysfunction and increased cardiovascular mortality, highlighting early metabolic dysregulation as a target to prevent heart failure with prese
This review synthesizes recent evidence on adult subvalvular aortic stenosis, highlighting long-term clinical outcomes, disease progression, and implications for management and follow-up strategy.
This review synthesizes evidence on the adoption and billing practices of telemedicine critical care for Medicare beneficiaries from 2018 to 2024, highlighting pandemic-driven shifts, provider and hospital characteristics influencing utiliz
A multimodal human factors program enhances team communication, nontechnical skills, and workflow during pediatric airway endoscopy, supporting OR culture change despite unchanged immediate clinical outcomes.
This review synthesizes contemporary evidence on the survival impact of adding defibrillators to CRT in nonischemic cardiomyopathy, highlighting heterogeneous results including the DECIDE-CRT study and underscoring the need for personalized
This review synthesizes clinical trial evidence supporting digital patient-reported outcome monitoring with alert-based interventions to reduce fatigue and improve physical functioning in metastatic breast cancer.
This review analyzes the increased incidence of migraine and sinus headaches in primary rhinoplasty patients, emphasizing the clinical significance of screening rhinogenic headache triggers during septorhinoplasty to enhance both symptomati
This review synthesizes evidence on individual and institutional factors linked to suspected suicide among higher-education students in England, highlighting risk profiles, service contact patterns, and shortcomings in investigation practic
This review synthesizes recent evidence on the effectiveness of 2024-2025 COVID-19 vaccines in adults, highlighting moderate protection against symptomatic illness, hospitalization, and critical outcomes, with emphasis on waning immunity an
Inflammatory blood biomarkers consistently predict long-term recurrent stroke risk up to 10 years post-event, independent of traditional vascular risk factors, underscoring the potential for anti-inflammatory secondary prevention strategies
This review explores the role of dysregulated iron metabolism and inflammation, particularly elevated serum ferritin, in isolated REM sleep behavior disorder (iRBD) as a prodromal stage of neurodegeneration, synthesizing recent longitudinal
Automated speech analysis of brief connected speech accurately identifies clinical, anatomical, and neuropathological variants of primary progressive aphasia, facilitating scalable diagnosis and monitoring.
This review synthesizes international evidence on survival in genetic frontotemporal dementia (FTD), highlighting key predictors such as age at onset, clinical phenotype, and motor symptoms, and discusses implications for patient care and t
Continuing antidepressants in pregnancy lowers postpartum depression risk irrespective of race or ethnicity; prenatal depressive symptoms severity is critical for personalized treatment.
Serum GFAP elevation predicts progression independent of relapse in MS; therapy-induced GFAP reduction associates with decreased progression risk, supporting GFAP as a biomarker for progression risk stratification and treatment monitoring.
This review synthesizes evidence from a large-scale multi-ancestry study revealing ancestry-specific distributions of Parkinson’s disease genetic variants, emphasizing the need for diverse population inclusion to optimize diagnosis an
A single moderate COPD exacerbation markedly increases future exacerbation risk and long-term mortality, justifying its reclassification as high risk per GOLD 2026 guidelines and supporting refined risk stratification for better clinical ma
This review synthesizes evidence on patients’ perceptions of telehealth for head and neck cancer surveillance, highlighting barriers, benefits, and the potential of hybrid models to improve acceptability post-treatment.
Postoperative colonic ischemia is a rare but severe complication after colectomy for colorectal cancer, primarily linked to specific resection types and vascular comorbidities, significantly impacting patient morbidity and mortality.
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