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Clinical Updates

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Understanding Key Stakeholders’ Perspectives Towards Artificial Intelligence in Home Care Work: An Evidence-Based Review

This review synthesizes perspectives from key stakeholders on AI integration in home care, highlighting benefits, risks, and governance challenges to inform equitable, sustainable AI adoption.

Sep 26, 2026
Clinical Updates

Biologic Outcomes in Severe Asthma by Smoking Status: Insights from the SHARP European Registry

SHARP registry data reveal that biologic therapies improve clinical outcomes equally in severe asthma patients irrespective of smoking status, challenging prevailing prescribing hesitancy and advocating inclusive treatment approaches.

Sep 26, 2026Sign in to read
Clinical Updates

Gastrointestinal Interoception and Relapse in Anorexia Nervosa: Insights from Behavioral, Neural, and Computational Perspectives

This review synthesizes evidence demonstrating disrupted gastrointestinal interoception in weight-restored anorexia nervosa, linking behavioral and neural disturbances with relapse risk and symptom severity, and highlighting novel mechanist

Sep 25, 2026
Clinical Updates

Mixed Mucus Plug-Emphysema Subtype and Acute Exacerbation in Chronic Obstructive Pulmonary Disease: A Quantitative CT Phenotyping Approach

Quantitative CT-defined mucus plugs combined with emphysema severity stratify COPD patients into distinct subtypes that predict risk of acute exacerbations, enabling personalized risk assessment and targeted preventive strategies.

Sep 25, 2026
Clinical Updates

Inequalities in Mortality Following SARS-CoV-2 Infection Among People with Severe Mental Illness During and After COVID-19 Vaccination Roll-Out in England: A Comprehensive Review

This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk

Sep 24, 2026
Clinical Updates

Epilepsy Risk Following Antipsychotic Use in Older Traumatic Brain Injury Survivors: Insights from a Population-Based Cohort Study

This review synthesizes evidence on the relationship between antipsychotic choice after traumatic brain injury (TBI) and post-traumatic epilepsy risk in older adults, highlighting recent population-based findings and mechanistic implication

Sep 24, 2026
Clinical Updates

Dose-Dependent Effects of Produce Prescriptions: Insights from a Randomized Community Trial and Broader Evidence

This review synthesizes evidence on produce prescription dosing, highlighting a randomized trial demonstrating dose-dependent improvements in redemption, food security, and fruit/vegetable intake, contextualized within the evolving literatu

Sep 24, 2026
Clinical Updates

Steatotic Liver Disease Risk Scores for Predicting Cirrhosis and Hepatocellular Carcinoma: A Comprehensive Clinical Review

This review assesses the clinical utility of steatotic liver disease risk scores in predicting cirrhosis and hepatocellular carcinoma, highlighting the superior performance of the SAFE score for cirrhosis and challenges in HCC risk predicti

Sep 24, 2026Sign in to read
Clinical Updates

Dynamic Genetic and Nongenetic RAS-Pathway Activation Drives Resistance to FLT3 and BCL2 Inhibitor Therapy in AML

This review synthesizes cutting-edge findings on how genetic and nongenetic RAS-pathway activation mediates resistance to combined FLT3 and BCL2 inhibition in acute myeloid leukemia, highlighting implications for treatment strategies and bi

Sep 24, 2026
Clinical Updates

Quantitative CT-Based Mixed Mucus Plug-Emphysema Phenotyping Predicts Exacerbation Risk in COPD: Integrating Imaging Biomarkers for Precision Medicine

This review synthesizes recent evidence on quantitative CT markers of mucus plugging and emphysema in COPD, highlighting their combined impact on acute exacerbation risk and clinical heterogeneity, and discusses implications for personalize

Sep 24, 2026
Clinical Updates

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes

This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunit

Sep 23, 2026
Clinical Updates

Insights from Neuron-Derived Extracellular Vesicle Biomarkers: PPARγ and GLP1 Receptor Agonists Modulate Brain Metabolism in CNS Insulin Resistance

This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond p

Sep 23, 2026Sign in to read
Clinical Updates

Impact of Age at Type 1 Diabetes Onset on Mortality and Organ Complications: Insights from a Nationwide Swedish Cohort

Younger age at type 1 diabetes diagnosis significantly increases risks of mortality, cardiovascular, and kidney complications; each additional year delay in onset reduces these risks. This review synthesizes nationwide cohort findings and c

Sep 23, 2026
Clinical Updates

Centralized Multidisciplinary Retinoblastoma Care: Closing Outcome Gaps in Resource-Limited Settings with Telemedicine and Advanced Globe Salvage

Centralized multidisciplinary retinoblastoma care incorporating telemedicine and international partnership at KHCC improved survival and globe salvage rates to levels comparable with high-income countries, demonstrating a scalable model for

Sep 23, 2026
Clinical Updates

Standalone Salpingectomy for Primary Ovarian Cancer Prevention: A Cost-Effectiveness Analysis

This review synthesizes evidence on the cost-effectiveness of standalone salpingectomy for ovarian cancer prevention, highlighting its benefits primarily in women at moderately elevated risk, especially between ages 45-50, supporting tailor

Sep 23, 2026
Clinical Updates

Whole-Grain Consumption and Cardiometabolic Risk: Evidence from Meta-Analyses of Randomized Controlled Trials

Higher whole-grain intake consistently improves multiple cardiometabolic risk factors, with optimal benefits at 60–100 g/day. Evidence highlights reductions in adiposity, blood lipids, inflammation, glucose, and blood pressure, supporting w

Sep 23, 2026Sign in to read
Clinical Updates

Emergency Medical Services Equipment Use in the Emergency Department and Its Impact on Time to Care in Out-of-Hospital Cardiac Arrest Patients

Use of EMS equipment in the ED is associated with shorter time to rhythm analysis and defibrillation for OHCA patients, potentially improving early resuscitation outcomes.

Sep 23, 2026
Clinical Updates

Dapirolizumab Pegol Improves Disease Activity in Systemic Lupus Erythematosus: Evidence from Phase 3 PHOENYCS GO Trial and Prior Studies

Dapirolizumab pegol, a CD40 ligand inhibitor, significantly improves disease activity in moderate-to-severe SLE over 48 weeks when added to standard care, supported by robust phase 3 trial data and pharmacokinetic findings.

Sep 22, 2026Sign in to read
Clinical Updates

Patient Perceptions of Quality of Shared Decision-Making for Lung Cancer Screening in Telehealth vs In-Person Discussions: A Synthesis of Evidence and Clinical Insights

This review synthesizes current evidence comparing patient-perceived quality of shared decision-making (SDM) for lung cancer screening (LCS) delivered via telehealth versus in-person encounters, highlighting comparable outcomes and implicat

Sep 22, 2026Sign in to read
Clinical Updates

Outcomes of As-Needed Aflibercept Treatment After Complete Regression in Polypoidal Choroidal Vasculopathy: A Clinical Review

This review synthesizes evidence on PRN aflibercept treatment after complete polypoidal regression in PCV, highlighting recurrence rates, visual outcomes, and potential OCT biomarkers guiding individualized management.

Sep 22, 2026Sign in to read
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    Physical Activity Trajectories Before and After Cardiovascular Disease: Insights from the CARDIA Study

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