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This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.
This review synthesizes the ASC4OPT trial results alongside pivotal evidence from the ASCEMBL and ASC4FIRST studies, evaluating the role of the STAMP inhibitor asciminib in chronic myeloid leukemia across multiple treatment lines.
A large-scale cohort study demonstrates that GLP-1 RAs significantly reduce macrovascular and microvascular complications, including proliferative retinopathy and retinal vein occlusion, in patients with pre-existing diabetic retinopathy.
High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.
This review synthesizes recent evidence, including a landmark 2026 meta-analysis, showing that blood pressure-lowering therapy provides similar cardiovascular benefits in patients with isolated diastolic hypertension compared to those with
This review synthesizes recent clinical evidence establishing Interleukin-2 as the primary biomarker for acute gluten exposure in celiac disease, revealing that immune activation occurs at doses significantly lower than currently used in fo
This review synthesizes recent evidence on the neuroprotective effects of healthy dietary patterns (Mediterranean, MIND), the synergistic impact of lifestyle and pharmacotherapy (GLP-1), and systemic advances in acute stroke care and second
This review synthesizes recent clinical evidence on the integration of plasma p-tau217 and eMTBR-tau243, highlighting how sequential biomarker testing improves the diagnosis of symptomatic Alzheimer’s disease and predicts longitudinal cogni
This review explores how polygenic risk scores and clinical factors like BMI and pregnancy history predict incident hypertension 2 to 7 years post-delivery, highlighting the dominance of modifiable risk factors over genetic predisposition.
The Essence-TIMI 73b trial reveals that despite a 64% reduction in triglycerides and a 72% drop in remnant cholesterol via olezarsen, non-calcified coronary plaque volume remained unchanged over 12 months.
This review synthesizes the evolving landscape of H. pylori management, highlighting the rise of P-CAB-based therapies, the impact of antibiotic resistance on global eradication strategies, and the expanding recognition of extragastric dise
The EDESTROKE trial finds no significant difference in 90-day functional outcomes between early (<6h) and delayed (6-12h) extubation post-thrombectomy, shifting focus toward microvascular and hemodynamic optimization.
This article synthesizes evidence from a 2026 Danish nationwide cohort and supporting literature, illustrating that renin-independent aldosterone production represents a continuous risk gradient for kidney failure and MACE, even below tradi
Bayesian re-analysis of the RELAx trial suggests a 75-78% probability that a lower PEEP strategy is superior to higher PEEP in ICU patients without ARDS, with even higher benefits observed in specific clinical subgroups.
This review synthesizes evidence on sex differences in syncope management, highlighting that while men face higher admission rates and adverse events, these disparities are largely driven by baseline clinical risk factors rather than gender
Recent multicenter data indicates that red blood cell exchange transfusion (ET) provides a nearly five-fold reduction in mortality and readmission for patients with severe babesiosis, challenging earlier smaller-scale observations.
This review explores the breakthrough potential of Bovine Herpesvirus Type 1 (BoHV-1) as an oncolytic agent in Multiple Myeloma, highlighting its ability to induce mitochondrial apoptosis, reprogram the immunosuppressive bone marrow niche,
This review synthesizes evidence that BCR::ABL1 inhibitors induce ribosome collisions and ZAK-dependent apoptosis, highlighting the ribotoxic stress response as a critical pathway for TKI efficacy and a potential target to overcome resistan
This review synthesizes recent evidence regarding the association between semaglutide initiation and nonarteritic anterior ischemic optic neuropathy (NAION), contrasting high-risk findings in real-world cohort studies with neutral findings
This review synthesizes evidence from the GISSG+2201 trial and related studies, demonstrating that supervised multimodal prehabilitation significantly reduces postoperative complications and enhances functional recovery in older, frail pati
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