Section
This review synthesizes recent evidence on immune checkpoint inhibitor (ICI)-based downstaging therapy for hepatocellular carcinoma (HCC) beyond Milan criteria prior to liver transplantation, highlighting improved oncologic outcomes alongsi
This review synthesizes current evidence highlighting limitations and opportunities in prenatal care data and metrics, emphasizing the potential of advanced monitoring, targeted interventions, and integrated data systems to improve maternal
GAD-alum immunotherapy significantly delays progression to stage 3 type 1 diabetes in children positive for the HLA-DR3-DQ2 haplotype, underscoring precision medicine’s role in managing autoimmunity.
This review synthesizes evidence from the DCCT/EDIC study highlighting the high prevalence and risk factors of obstructive sleep apnea and poor sleep quality in older adults with long-standing type 1 diabetes, emphasizing the clinical and m
Out-of-area psychiatric admissions in youth are linked to increased emergency and non-mental health hospital use up to five years post-discharge, highlighting key implications for integrated service planning and care continuity.
This review synthesizes long-term immunogenicity data from a South African RCT comparing 1+1 and 2+1 infant PCV10 and PCV13 schedules. PCV13 1+1 schedules maintain durable immunity up to age 5, supporting schedule optimization in establishe
Out-of-area psychiatric admissions in young people are linked to increased emergency and non-mental health hospital use up to 5 years post-discharge, underscoring service planning needs in CAMHS.
This review synthesizes national data from Spain (2015-2024) revealing a decline in brain death donation (DBD) offset by growth in controlled donation after circulatory death (cDCD), alongside evolving neurocritical care practices influenci
A hybrid RCT among 630 Latino caregiver-infant dyads demonstrates that text messaging and community resource referrals augment primary care literacy promotion, improving language, social-emotional development, and parenting behaviors.
This review synthesizes current evidence on ruxolitinib 1.5% cream efficacy and safety in cutaneous lichen planus, highlighting significant lesion and pruritus reduction in a pivotal phase 2 RCT, supporting its potential as a novel topical
This review synthesizes evidence linking hearing loss to regional brain amyloid deposition, highlighting recent in vivo PET findings, meta-analytic data on AD neuropathology, and amyloid-related inner ear pathology, discussing potential mec
This review evaluates whether sentinel lymph node biopsy omission, validated in SOUND and INSEMA trials, applies to cT1N0 invasive lobular carcinoma, highlighting nodal positivity rates, risk factors such as lymphovascular invasion, and cli
Unsupervised clustering defines three structural phenotypes in chronic CSC, linking photoreceptor damage with choroidal changes and visual prognosis, refining disease stratification beyond photoreceptor staging alone.
This review presents a comprehensive ten-year update on global corneal transplantation and eye banking, highlighting persistent supply-demand gaps, income-based disparities, surgical trends, and emerging innovations to improve equitable acc
The LIMS study demonstrates sustained, modest improvements in MS-related functioning and dietary behavior up to 24 months following a digital multimodal lifestyle intervention, supporting lifestyle interventions as complementary to MS manag
This review elucidates fibrocytes’ critical role in JAK2V617F-mutated myelofibrosis pathogenesis and evaluates pitavastatin’s promising therapeutic effects in reversing marrow fibrosis and anemia, integrating mechanistic insights and
This review synthesizes evidence comparing diabetes duration and advanced complications between patients undergoing revascularization for lower extremity artery disease (LEAD) and coronary artery disease (CAD), highlighting the heavier diab
This review analyzes global sex disparities in cancer incidence, highlighting modifiable lifestyle and health factors — notably smoking, alcohol, and obesity — as key contributors differing by population context, with implications for tailo
This review synthesizes evidence that modern personalized surgical strategies for vulvar squamous cell carcinoma enhance survival outcomes despite higher reoperation rates, emphasizing evolving surgical techniques, sentinel lymph node biops
The EMBOL-AF Global Registry provides comprehensive data on stroke and systemic embolism post-atrial fibrillation ablation, highlighting incidence, timing, risk factors, and procedural impacts alongside evolving ablation strategies and long
