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This review synthesizes recent evidence on pregnancy-related anemia, highlighting a 25.6% US prevalence, the clinical significance of iron deficiency without anemia (IDWA), and the critical impact on maternal-fetal outcomes and cardiovascul
This review synthesizes the evolving landscape of noninvasive tests (NITs) in MASH, detailing their role as surrogate endpoints for adverse outcomes and therapeutic response based on recent clinical trials and meta-analyses.
Recent advances in digital pathology and machine learning reveal that APOE ε4 promotes proteinopathy and modifies dementia thresholds, while multi-modal trajectories suggest distinct pathways for disease progression in Lewy body disease.
The Phase 4 RESOLUTION trial demonstrates that eptinezumab 100 mg IV, combined with standardized patient education, significantly reduces migraine frequency and acute medication reliance in adults with comorbid chronic migraine and medicati
This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and M
This review synthesizes the 54-month results of the ATTRibute-CM open-label extension, demonstrating that early and continuous acoramidis treatment provides sustained reductions in mortality and cardiovascular hospitalizations while maintai
This review analyzes evidence demonstrating that cardiologist evaluation for peri-operative myocardial infarction/injury (PMI) significantly reduces 1-year major adverse cardiac events and all-cause mortality through optimized diagnostic an
This review synthesizes recent evidence identifying MR-proADM as a premier prognostic biomarker in ATTR-CM, demonstrating its ability to outperform traditional natriuretic peptides and enhance existing clinical staging systems.
This review evaluates the optimal sequencing of radiotherapy and immunotherapy in advanced NSCLC, highlighting real-world evidence from the OCEANUS study favoring sequential over concurrent administration.
This review synthesizes findings from a landmark proteomic study identifying 23 plasma proteins associated with VTE risk, highlighting novel pathways in immunity and vascular senescence while exploring causal links through Mendelian Randomi
This review analyzes the association between in utero prescription opioid exposure and third-grade academic outcomes, highlighting a distinct risk signal for tramadol compared to codeine and oxycodone **Outlining Key Sections** I’m no
This review analyzes community-validated strategies to improve biobanking engagement among Black women with endometrial cancer, highlighting return-of-value, transparency, and trust-building as essential components for reducing health dispa
This review analyzes a decade-long nationwide study on TB after Allo-HSCT in France, revealing a 60/100,000 incidence rate, high extrapulmonary involvement, and the critical need for screening patients from high-incidence regions.
This review analyzes the complex factors influencing blood pressure management in older adults, highlighting how age, frailty, and digital health data shape clinician decisions and clinical inertia.
This review synthesizes recent evidence on the massive scale of CKM medication eligibility in the US, the synergistic effects of pharmacotherapy with lifestyle, and emerging neuropsychiatric benefits of GLP-1 receptor agonists.
This secondary analysis of the DANFLU-2 trial demonstrates that high-dose influenza vaccines provide superior protection against cardiorespiratory and cardiovascular hospitalizations in older adults with diabetes, particularly those with a
The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a novel selective D1/D5 agonist, significantly improves daily ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s disease patients with motor fluctuations, pres
A longitudinal study using Latent Class Analysis identifies four distinct phenotypes of T2D patients developing CKD, highlighting young-onset and middle-aged low-comorbidity groups as primary drivers of healthcare costs.
This review analyzes a landmark machine learning study identifying four distinct GDM phenotypic clusters, revealing that early-diagnosed, comorbidity-related GDM carries a four-fold higher risk of postpartum diabetes.
This review synthesizes the trajectory of PCSK9 inhibitors, from pivotal monoclonal antibody trials to emerging RNA interference and gene-editing technologies, emphasizing their role in achieving ultra-low LDL-C levels and reducing major ad
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