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An evidence-based review of the 7-year durability of transcatheter versus surgical aortic bioprosthetic valves in low-risk severe aortic stenosis patients, highlighting comparable long-term structural performance and need for reintervention
This review synthesizes evidence on the prevalence, incidence, and prognosis of cancer and heart failure comorbidity in Scotland, integrating recent cohort data and cardio-oncology research to inform clinical practice and future research di
The Ross procedure in adults demonstrates excellent long-term survival, valve durability, and low reintervention rates, supporting its broader use in selected patients at experienced centers.
This prospective cohort study investigates how fructose-containing beverages and foods, including sugar-sweetened beverages, fruit juices, and whole fruits, consumed from childhood through adulthood influence hypertension risk, highlighting
Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.
This study reveals that sudden death in heart failure patients often follows gradual clinical decline, challenging the notion that such deaths are always abrupt.
This article reviews how SLC4A3 gene mutations cause short QT syndrome by inducing intracellular alkalinization and altered ion channel currents, increasing arrhythmia risk, based on stem cell-derived cardiomyocyte models.
This analysis reveals comparable 10-year mortality, valve durability, and hemodynamics between SAPIEN 3 transcatheter and surgical aortic valve replacement in intermediate-risk patients, underscoring TAVR’s durable benefit.
In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.
In over 1 million US veterans, the 2024-2025 COVID-19 vaccine was associated with fewer COVID-19-related cardiovascular events, with the strongest benefit in adults over 75 and those with comorbidities.
Post hoc SURPASS-CVOT analysis found tirzepatide lowered a broad 6-component cardiorenal composite versus dulaglutide in high-risk patients with type 2 diabetes, with more gastrointestinal adverse events but similar overall safety.
The VISION Cardiac Surgery cohort found POAF in about one-third of patients, with wide variation in discharge treatment. POAF strongly predicted later atrial fibrillation and was associated with higher 1-year mortality.
The PARTNER 2A 10-year data show higher mortality and reintervention with balloon-expandable SAPIEN XT TAVR versus surgery in intermediate-risk patients, driven mainly by transthoracic access. Contemporary 10-year SAPIEN 3 data, however, su
Researchers found that Galectin-3 boosts CaV1.2 calcium channel activity in blood vessel muscle, increasing contraction and blood pressure. Blocking this interaction lowered blood pressure in animal models, suggesting a new target for hyper
Elamipretide improved skeletal muscle force, titin phosphorylation, and atrophy in a HFpEF rat model, supporting cardiolipin stabilization as a promising mitochondrial-targeted strategy.
In a HFpEF rat model, Elamipretide improved muscle force, reduced titin abnormalities, and prevented atrophy, supporting cardiolipin stabilization as a potential strategy for exercise intolerance.
In a HFpEF rat model, elamipretide improved skeletal muscle force, reduced titin hyperphosphorylation, and prevented atrophy, supporting cardiolipin stabilization as a promising metabolic strategy.
In a rat model of HFpEF, the mitochondrial-targeted peptide elamipretide improved skeletal muscle force, reduced atrophy, and normalized titin phosphorylation, supporting cardiolipin stabilization as a promising mechanism.
The iSCAD Registry study highlights distinctive reproductive and psychosocial features among women with pregnancy-associated SCAD, underscoring the need for individualized counseling, heightened diagnostic suspicion, and multidisciplinary f
In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.
