Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure
Highlights
Blood-based DNA methylation patterns were associated with carotid, coronary, and peripheral atherosclerosis in two prospective cohorts involving 3,688 participants.
Most atherosclerosis-associated CpG sites overlapped with sites linked to smoking, inflammation, or metabolic risk traits, suggesting that the epigenetic signal largely reflects cumulative exposure.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.