Cardiolipin Stabilization Revives Skeletal Muscle Performance in a Preclinical HFpEF Model
Highlights
In a female rat model of heart failure with preserved ejection fraction (HFpEF), skeletal muscle showed evidence of mitochondrial dysfunction, reduced cardiolipin content, contractile impairment, titin abnormalities, and muscle atrophy.
Elamipretide (SS-31), a mitochondria-targeted peptide that stabilizes cardiolipin, improved whole-muscle force, enhanced single-fiber performance, and prevented further muscle wasting.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.