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Integrating Trauma-Focused Therapy with Cognitive Behavioural Therapy for Psychosis: Insights from the STAR Trial and Related Research
Clinical UpdatesCBTpPsychosis

Integrating Trauma-Focused Therapy with Cognitive Behavioural Therapy for Psychosis: Insights from the STAR Trial and Related Research

By MedXY|Jul 12, 2026

The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.

Delusions as Embodied Emotions: Rethinking First-Episode Psychosis through Narrative and Phenomenological Inquiry
newsPsychosis

Delusions as Embodied Emotions: Rethinking First-Episode Psychosis through Narrative and Phenomenological Inquiry

By MedXY|Jan 29, 2026

A multimethod study suggests that delusions in first-episode psychosis are ’embodied emotions’—global transformations of self-experience shaped by life narratives, particularly early shame and trauma. This research challenges tr

Glutamate Surges in Early Psychosis: Why Timing Matters for Targeted Therapeutics
newsMagnetic Resonance SpectroscopyPsychosis

Glutamate Surges in Early Psychosis: Why Timing Matters for Targeted Therapeutics

By MedXY|Jan 25, 2026

A cross-sectional study of never-medicated individuals reveals that elevated medial prefrontal cortex glutamate levels are specific to the first episode of psychosis and correlate with cognitive deficits, suggesting a critical window for gl

Transdiagnostic Prediction Model Accurately Identifies Risk for Psychotic and Bipolar Disorders in Clinical Practice
newsbipolar disorderElectronic Health Records

Transdiagnostic Prediction Model Accurately Identifies Risk for Psychotic and Bipolar Disorders in Clinical Practice

By MedXY|Dec 20, 2025

Researchers developed a clinical prediction model using electronic health records from over 127,000 patients to identify individuals at risk of psychotic or bipolar disorders. The model demonstrated high discriminative power (C-index 0.80)

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders
Neurologybrain structurecognition

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders

By MedXY|Oct 30, 2025

This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized

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