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MedXY AI/MedXY News/Tag: Polygenic Risk Scores
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Polygenic Risk Scores

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Integrating Rare and Common Variants: The Synergistic Role of rCNVs and Polygenic Scores in Psychiatric Risk Stratification
Clinical Updatescopy number variantsGenetic Psychiatry

Integrating Rare and Common Variants: The Synergistic Role of rCNVs and Polygenic Scores in Psychiatric Risk Stratification

By MedXY|May 31, 2026

This review synthesizes evidence on how recurrent copy number variants (rCNVs) and polygenic scores (PGSs) jointly influence psychiatric risk, highlighting their complementary roles in clinical risk assessment and the emergence of precision

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY
Diabetes & Endocrinologyendocrinology
GCK-MODY

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY

By MedXY|Mar 20, 2026

This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the

Decoding Antidepressant Response: Genetic and Phenotypic Markers of Treatment Complexity and Sustained Use
newsantidepressantsmajor depressive disorder

Decoding Antidepressant Response: Genetic and Phenotypic Markers of Treatment Complexity and Sustained Use

By MedXY|Jan 31, 2026

A large-scale retrospective cohort study identifies specific phenotypic traits and genetic markers, including the SLAMF3/LY9 locus, that predict antidepressant treatment complexity and sustained use, offering a roadmap for precision psychia

Genetic Tug-of-War: How Polygenic Background Dictates the Penetrance and Phenotype of Monogenic Cardiomyopathies
CardiologycardiomyopathyGenetic penetrance

Genetic Tug-of-War: How Polygenic Background Dictates the Penetrance and Phenotype of Monogenic Cardiomyopathies

By MedXY|Dec 23, 2025

A large-scale study from the Penn Medicine BioBank demonstrates that polygenic risk scores for hypertrophic and dilated cardiomyopathies act as bidirectional modifiers, influencing the clinical expression of rare pathogenic variants and off

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