Cardiologyatrial fibrillationCardiac Glutamatergic System
Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial
By MedXY|Mar 20, 2026
This phase 2 trial demonstrates that memantine, an NMDA receptor antagonist, significantly reduces premature atrial contractions (PACs) and nonsustained atrial tachycardia burden, suggesting the cardiac glutamatergic system as a novel thera